ReviewClinical autonomic research : official journal of the Clinical Autonomic Research Society2020
Diagnosing multiple system atrophy at the prodromal stage.
Review in Clinical autonomic research : official journal of the Clinical Autonomic Research Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 28 citations in OpenAlex.
- Multiple system atrophy: cure and care.Journal of neural transmission (Vienna, Austria : 1996) · 2026Review
- Prospective Validation of the Movement Disorder Society Prodromal Multiple System Atrophy Criteria in Pure Autonomic Failure.Movement disorders : official journal of the Movement Disorder Society · 2026Article
- Refining the diagnostic accuracy of Parkinsonian disorders using metaphenomic annotation of the clinicopathological literature.NPJ Parkinson's disease · 2025Article
- Cortical macro- and microstructural changes in isolated rapid eye movement sleep behavior disorder.NPJ Parkinson's disease · 2025Article
- From mechanisms to future therapy: a synopsis of isolated REM sleep behavior disorder as early synuclein-related disease.Molecular neurodegeneration · 2025Review
- A challenging case presentation of multiple system atrophy cerebellar type: A rare case report from Somalia.Radiology case reports · 2024Article
- Reduced cardiacBrain communications · 2024Article
- Image features of anti-SEZ6L2 encephalitis, a rare cause of ataxia and parkinsonism.Journal of neurology · 2023Article
- α-Synuclein-carrying astrocytic extracellular vesicles in Parkinson pathogenesis and diagnosis.Translational neurodegeneration · 2023Article
- Cancer in pathologically confirmed multiple system atrophy.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2023Article
- Inaccurate self-report of olfactory dysfunction in REM Sleep Behaviour Disorder and implications for prognosis.Clinical parkinsonism & related disorders · 2023Article
- Odor identification predicts the transition of patients with isolated RBD: A retrospective study.Annals of clinical and translational neurology · 2022Article
- Improving the Accuracy of Diagnosis for Multiple-System Atrophy Using Deep Learning-Based Method.Biology · 2022Article
- Heterogeneity of Multiple System Atrophy: An Update.Biomedicines · 2022Review
- Determinants of cognitive impairment in multiple system atrophy: Clinical and genetic study.PloS one · 2022Article
- Female sexual dysfunction in multiple system atrophy: does it matter?Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2021Article
- A historical review of multiple system atrophy with a critical appraisal of cellular and animal models.Journal of neural transmission (Vienna, Austria : 1996) · 2021Review
- Comparison between four published definitions of hyposmia in Parkinson's disease.Brain and behavior · 2021Article
- REM Sleep Behaviour Disorder in Multiple System Atrophy: From Prodromal to Progression of Disease.Frontiers in neurology · 2021Review
- Current Management and Emerging Therapies in Multiple System Atrophy.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2020Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Identifying individuals at the earliest disease stage becomes crucial as we aim to develop disease-modifying treatments for neurodegenerative disorders. Prodromal diagnostic criteria were recently developed for Parkinson's disease (PD) and are forthcoming for dementia with Lewy bodies (DLB). The latest 2008 version of diagnostic criteria for multiple system atrophy (MSA) have improved diagnostic accuracy in early disease stages compared to previous criteria, but we do not yet have formal criteria for prodromal MSA. Building on similar approaches as for PD and DLB, we can identify features on history-taking, clinical examination, and ancillary clinical testing that can predict the likelihood of an individual developing MSA, while also distinguishing it from PD and DLB. The main clinical hallmarks of MSA are REM sleep behavior disorder (RBD) and autonomic dysfunction (particularly orthostatic hypotension and urogenital symptoms), and may be the primary means by which patients with potential prodromal MSA are identified. Preserved olfaction, absence of significant cognitive deficits, urinary retention, and respiratory symptoms such as stridor and respiratory insufficiency can be clinical features that help distinguish MSA from PD and DLB. Finally, ancillary test results including neuroimaging as well as serological and cerebrospinal fluid (CSF) biomarkers may lend further weight to quantifying the likelihood of phenoconversion into MSA. For prodromal criteria, the primary challenges are MSA's lower prevalence, shorter lead time to diagnosis, and strong overlap with other synucleinopathies. Future prodromal criteria may need to first embed the diagnosis into a general umbrella of prodromal alpha-synucleinopathies, followed by identification of features that suggest prodromal MSA as the specific cause.
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