ArticleWorld journal of pediatrics : WJP2020
Prediction of intravenous immunoglobulin resistance in Kawasaki disease in children.
Article in World journal of pediatrics : WJP, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 3 of them syntheses that pooled it.
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Who cites it
33 citing papers in PubMed, 3 syntheses or guidelines pooled it, 44 citations in OpenAlex.
- Quality and performance of machine learning versus logistic regression for predicting IVIG resistance in Kawasaki disease: a PROBAST+AI systematic comparison.BMC medical research methodology · 2026Pooled it
- Prevalence of IVIG resistance in Kawasaki disease: a systematic review and meta-analysis.Frontiers in pediatrics · 2025Pooled it
- C-reactive protein to albumin ratio as a prognostic tool for predicting intravenous immunoglobulin resistance in children with kawasaki disease: a systematic review of cohort studies.Pediatric rheumatology online journal · 2024Pooled it
- Machine learning model for intravenous immunoglobulin resistance in Kawasaki disease: model development and validation study.World journal of pediatrics : WJP · 2026Article
- Predictive value of the hemoglobin-albumin-lymphocyte-platelet score for intravenous immunoglobulin resistance in children with Kawasaki disease.Italian journal of pediatrics · 2026Article
- Value of peripheral blood cell parameters and their derived ratios in predicting intravenous immunoglobulin resistance in Kawasaki disease.Italian journal of pediatrics · 2026Article
- A nomogram for predicting Kawasaki Disease in acutely febrile children with liver injury.European journal of pediatrics · 2026Article
- Neutrophil heterogeneity in Kawasaki disease and multisystem inflammatory syndrome in children.Pediatric research · 2026Review
- Expression of key genes in IVIG-unresponsive Kawasaki disease and their immune correlation based on bioinformatics analysis.Immunologic research · 2026Article
- Decoding clinical heterogeneity and age-related coronary risk in incomplete Kawasaki disease: a multicenter cluster analysis and structural equation modeling study.Frontiers in immunology · 2026Article
- Nomogram to predict severeFrontiers in pediatrics · 2026Article
- Construction and subgroup validation of a predictive model for IVIG-resistance in kawasaki disease.Frontiers in cardiovascular medicine · 2026Article
- Association between C-reactive protein-albumin-lymphocyte (CALLY) index with intravenous immunoglobulin non-response in Kawasaki disease.Annals of medicine · 2025Article
- Interpretable web-based machine learning model for predicting intravenous immunoglobulin resistance in Kawasaki disease.Italian journal of pediatrics · 2025Article
- A machine learning-based model to predict intravenous immunoglobulin resistance in Kawasaki disease.iScience · 2025Article
- Establishment and validation of a nomogram for predicting intravenous immunoglobulin resistance and coronary artery lesion involvement in Kawasaki disease: a retrospective study.Clinical rheumatology · 2025Article
- [Development of a predictive scoring model for non-response to intravenous immunoglobulin in Kawasaki disease].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2025Article
- Nutrition-Associated Biomarkers in Predicting Intravenous Immunoglobulin Resistance and Coronary Artery Lesions in Kawasaki Disease: A Systematic Review and Meta-Analysis.Food science & nutrition · 2025Review
- Analysis and validation of clinical subgroups of Kawasaki disease in children in China: a retrospective study.BMJ paediatrics open · 2024Article
- [Predictive value of peripheral blood lymphocyte subsets for children with intravenous immunoglobulin-resistant Kawasaki disease].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2023Article
Corrections and comments
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Authors and funding
13 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWe aimed to explore predictive measures for intravenous immunoglobulin (IVIG) resistance in children with Kawasaki disease (KD).
methodsPatients diagnosed with KD were enrolled in this study. Univariate analysis and multiple logistic regression were utilized to analyze the clinical features and laboratory results prior to IVIG-treatment of the two groups. Independent predictors of IVIG resistance were analyzed, and a predictive model for KD children with IVIG resistance was constructed.
resultsA total of 277 children with KD, 180 boys and 97 girls, aged 2-128 (median 23) months, were enrolled in the study. Compared with the IVIG-responsive group, the IVIG-resistant group had higher levels of the peripheral neutrophil count, mean platelet volume, mean platelet volume-to-lymphocyte ratio and C-reactive protein, and total serum bilirubin, but lower levels of peripheral lymphocyte count, serum albumin and serum prealbumin. Age (in months), peripheral neutrophil count, lymphocyte count and mean platelet volume and serum albumin were independent indicators for IVIG resistance by multivariate logistic regression analysis. A logistic regression model and a scoring system were set up, where cut-off values of - 0.46 and 6.5 points yielded sensitivities of 83.9% and 77.4%, and specificities of 74.8% and 61.0%, respectively. The areas under the curve (AUC) were 0.808 in the logistic regression model, and 0.750 in the scoring system.
conclusionOur model for predicting IVIG-resistant children with KD, involving age (months), peripheral neutrophil count, lymphocyte count and mean platelet volume and serum albumin prior to IVIG-treatment, is helpful for clinical prediction of children with IVIG-resistant KD.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.