Evidence map›Paper›PMID 32232560›Full record

ArticleVirchows Archiv : an international journal of pathology2020

Tumor infiltrative growth pattern correlates with the immune microenvironment and is an independent factor for lymph node metastasis and prognosis in stage T1 esophageal squamous cell carcinoma.

Yuanyuan Zhao, Enwei Xu, Xuanqin Yang, Yong Zhang, Hong Chen, Ying Wang, Mulan Jin

Abstract read
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In one paragraph

Article in Virchows Archiv : an international journal of pathology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 3 pooled it
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 3 syntheses or guidelines pooled it, 31 citations in OpenAlex.

  1. Clinicopathological and prognostic value of tertiary lymphoid structures in lung cancer: a meta-analysis.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Yuanyuan ZhaoDepartment of Pathology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.
Enwei XuDepartment of Pathology, Shanxi Cancer Hospital, Taiyuan, China.
Xuanqin YangDepartment of Pathology, Shanxi Cancer Hospital, Taiyuan, China.
Yong ZhangDepartment of Gastroenterology, Shanxi Cancer Hospital, Taiyuan, China.
Hong ChenDepartment of Pathology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.
Ying WangDepartment of Pathology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.
Mulan JinDepartment of Pathology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China. kinmokuran@163.com.
Capital Medical University · CNShanxi Provincial Cancer Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this retrospective study, we analyzed the association between the tumor infiltrative growth pattern (INF) and tumor immune environment and its predictive value for lymph node metastasis and overall survival (OS) in stage T1 esophageal squamous cell carcinoma (ESCC). In total, 593 patients with a diagnosis of stage T1 ESCC who underwent esophagectomy and regional lymphadenectomy between 2009 and 2018 were included. The INF type and elements of the tumor immune microenvironment, including tumor infiltrative lymphocytes (TILs) and tertiary lymphoid structures (TLSs), were microscopically evaluated within the tumor invasive margin with hematoxylin and eosin (HE)-stained slices. The infiltrative-type INF (INFc) was associated with low-grade TILs and the absence of TLSs, deep tumor invasion, poorly differentiated phenotype. Multivariate logistic regression identified INFc as one of the independent risk factors for lymph node metastasis. INFc and low-grade TILs were independent inferior predictive factors for OS. A novel histologic risk stratification model was classified as INFa/b and high-grade TILs, INFa/b and low-grade TILs, INFc and high-grade TILs, and INFc and low-grade TILs. The Kaplan-Meier curves showed that INFa/b and high-grade TILs were associated with the best prognosis, and INFc and low-grade TILs were associated with the worst prognosis, and there was significant difference between groups. In conclusion, INFc is an independent risk factor for lymph node metastasis and an independent inferior prognostic factor for stage T1 ESCC. Furthermore, INFc is associated with immunosuppression, and the combination of the INF and TILs is useful for the risk stratification of prognosis.

Indexed as

AdultAgedAged, 80 and overChinaEsophageal NeoplasmsEsophageal Squamous Cell CarcinomaFemaleHumansLymphatic MetastasisLymph Node ExcisionLymph NodesLymphocytes, Tumor-InfiltratingMaleMiddle AgedNeoplasm MetastasisPrognosisEsophageal squamous cell carcinomaInfiltrative growth patternOverall survivalTertiary lymphoid structuresTumor immune microenvironmentTumor-infiltrating lymphocytes

Identifiers

PMID32232560
OpenAlexW3012990420

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.