Evidence map›Paper›PMID 32232547›Full record

SynthesisEuropean journal of pediatrics2020

High flow nasal cannula as respiratory support in treating infant bronchiolitis: a systematic review.

Lien Moreel, Marijke Proesmans

Registry-linked trialAbstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in European journal of pediatrics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06176664 (Oxygen Therapy for Children With Moderate Hypoxemia in Malawi), which is not on this map. Cited by 34 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 3 pooled it
5.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06176664 nacompletednot on this mapstarted 2024, after this paper: background citation

Oxygen Therapy for Children With Moderate Hypoxemia in Malawi: Pilot Randomized Control Trial

TypeinterventionalSponsorJohns Hopkins UniversityRan2024 to 2024Enrolled21ConditionsPneumoniaArmsLow flow oxygen, High-flow nasal cannula oxygen
3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 3 syntheses or guidelines pooled it, 61 citations in OpenAlex.

  1. Pooled it
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  6. Observational
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  19. Review
  20. Respiratory Syncytial Virus Infection: An Update.Indian journal of pediatrics · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Lien MoreelDepartment of Internal Medicine, University Hospitals Leuven, Leuven, Belgium.
Marijke ProesmansDepartment of Pediatrics, University Hospitals Leuven, Leuven, Belgium. marijke.proesmans@uzleuven.be.
KU Leuven · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bronchiolitis is a common respiratory illness in early childhood, often leading to hospitalization and associated healthcare costs. Low flow 100% oxygen through nasal prongs is the standard therapy for infants with bronchiolitis and hypoxemia. Nasal continuous positive airway pressure (nCPAP) or invasive ventilation is used in case of progressive respiratory failure. High flow heated and humidified oxygen therapy with delivery of an air-oxygen mixture up to 2 L/min/kg body weight via nasal prongs (referred to as high flow nasal cannula or HFNC) is a newer method for respiratory support. Initial data from retrospective studies were promising but should be interpreted with caution. A limited number of prospective randomized controlled trials (RCT) have now compared HFNC with either standard oxygen therapy (SOT) or nCPAP. In this review, we critically summarize the data from these RCTs with the aim to provide advice on how to position HFNC in clinical practice.Conclusion: HFNC is a safe mode of respiratory support that can be positioned between SOT and nCPAP as rescue therapy for children not adequately supported by SOT. It does not seem to shorten the duration of oxygen need nor the duration of hospital admission.What is Known:• HFNC is being used increasingly in the context of infant bronchiolitis. However, evidence on efficacy and safety are limited. Different published studies involve different disease severities and different pediatric settings.What is New:• In this review, we summarize data only from prospective RCTs with the aim to provide guidance on how to use HFNC.

Indexed as

Bronchiolitis, ViralCannulaChild, PreschoolContinuous Positive Airway PressureHumansInfantOxygen Inhalation TherapyRandomized Controlled Trials as TopicTreatment FailureBronchiolitisHigh flow nasal cannulaLength of hospital stayTherapy failure

Identifiers

PMID32232547
OpenAlexW3013288073

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.