Evidence map›Paper›PMID 32232525›Full record

ReviewAbdominal radiology (New York)2020

How should radiologists incorporate non-imaging prostate cancer biomarkers into daily practice?

Pawel Rajwa, Jamil Syed, Michael S Leapman

Abstract readReview
In one paragraph

Review in Abdominal radiology (New York), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Prostate Cancer Radiogenomics-From Imaging to Molecular Characterization.International journal of molecular sciences · 2021
    Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Pawel RajwaDepartment of Urology, Medical University of Silesia, 41-800, Zabrze, Poland.
Jamil SyedDepartment of Urology, Yale University School of Medicine, 310 Cedar Street BML 238c, PO Box 208058, New Haven, CT, 06520, USA.
Michael S LeapmanDepartment of Urology, Yale University School of Medicine, 310 Cedar Street BML 238c, PO Box 208058, New Haven, CT, 06520, USA. michael.leapman@yale.edu.ORCID http://orcid.org/0000-0002-0727-7614

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Understanding the Adoption and Impact of New Risk Assessment Technologies in Prostate Cancer CareK08CA237872 · NCI · YALE UNIVERSITY · PI LEAPMAN, MICHAEL STUART · 2019 to 2023
$1.1M
NCATS NIH HHS UL1 TR001863NCI NIH HHS K08 CA237872
6 · The paper itself

Abstract

objectiveTo review the current body of evidence surrounding non-imaging biomarkers in patients with known or suspected prostate cancer.

resultsSeveral non-imaging biomarkers have been developed and are available that aim to improve risk estimates at several clinical junctures. For patients with suspicion of prostate cancer who are considering first-time or repeat biopsy, blood- and urine-based assays can improve the prediction of harboring clinically significant disease and may reduce unnecessary biopsy. Blood- and urine-based biomarkers have been evaluated in association with prostate MRI, offering insights that might augment decision-making in the pre and post-MRI setting. Tissue-based genomic and proteomic assays have also been developed that provide independent assessments of prostate cancer aggressiveness that can complement imaging.

conclusionA growing number of non-imaging biomarkers are available to assist in clinical decision-making for men with known or suspected prostate cancer. An appreciation for the intersection of imaging and biomarkers may improve clinical care and resource utilization for men with prostate cancer.

Indexed as

Biomarkers, TumorProstatic NeoplasmsHumansMagnetic Resonance ImagingMaleProteomicsRadiologistsBiomarkers, TumorBiomarkersMolecular markersMRIProstate biopsy non-imaging biomarkersProstate cancer

Identifiers

PMID32232525
PMCPMC7529677

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.