Evidence map›Paper›PMID 32232512›Full record

ArticleArchives of toxicology2020

Glyphosate and AMPA levels in human urine samples and their correlation with food consumption: results of the cross-sectional KarMeN study in Germany.

Sebastian T Soukup, Benedikt Merz, Achim Bub, Ingrid Hoffmann, Bernhard Watzl, Pablo Steinberg, Sabine E Kulling

Open access · hybridAbstract read
In one paragraph

Article in Archives of toxicology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 88 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Sebastian T Soukup *Department of Safety and Quality of Fruit and Vegetables, Max Rubner-Institut, Haid-und-Neu-Straße 9, 76131, Karlsruhe, Germany.
Benedikt Merz *Department of Physiology and Biochemistry of Nutrition, Max Rubner-Institut, Karlsruhe, Germany.ORCID https://orcid.org/0000-0002-6856-3390
Achim BubDepartment of Physiology and Biochemistry of Nutrition, Max Rubner-Institut, Karlsruhe, Germany.ORCID https://orcid.org/0000-0001-6907-5519
Ingrid HoffmannDepartment of Nutritional Behaviour, Max Rubner-Institut, Karlsruhe, Germany.
Bernhard WatzlDepartment of Physiology and Biochemistry of Nutrition, Max Rubner-Institut, Karlsruhe, Germany.ORCID https://orcid.org/0000-0003-0762-7423
Pablo SteinbergMax Rubner-Institut, Karlsruhe, Germany.
Sabine E KullingDepartment of Safety and Quality of Fruit and Vegetables, Max Rubner-Institut, Haid-und-Neu-Straße 9, 76131, Karlsruhe, Germany. sabine.kulling@mri.bund.de.ORCID https://orcid.org/0000-0002-9956-2702
Max Rubner Institut · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glyphosate (N-[phosphonomethyl]-glycine) is the most widely used herbicide worldwide. Due to health concerns about glyphosate exposure, its continued use is controversially discussed. Biomonitoring is an important tool in safety evaluation and this study aimed to determine exposure to glyphosate and its metabolite AMPA, in association with food consumption data, in participants of the cross-sectional KarMeN study (Germany). Glyphosate and AMPA levels were measured in 24-h urine samples from study participants (n = 301). For safety evaluation, the intake of glyphosate and AMPA was calculated based on urinary concentrations and checked against the EU acceptable daily intake (ADI) value for glyphosate. Urinary excretion of glyphosate and/or AMPA was correlated with food consumption data. 8.3% of the participants (n = 25) exhibited quantifiable concentrations (> 0.2 µg/L) of glyphosate and/or AMPA in their urine. In 66.5% of the samples, neither glyphosate (< 0.05 µg/L) nor AMPA (< 0.09 µg/L) was detected. The remaining subjects (n = 76) showed traces of glyphosate and/or AMPA. The calculated glyphosate and/or AMPA intake was far below the ADI of glyphosate. Significant, positive associations between urinary glyphosate excretion and consumption of pulses, or urinary AMPA excretion and mushroom intake were observed. Despite the widespread use of glyphosate, the exposure of the KarMeN population to glyphosate and AMPA was found to be very low. Based on the current risk assessment of glyphosate by EFSA, such exposure levels are not expected to pose any risk to human health. The detected associations with consuming certain foods are in line with reports on glyphosate and AMPA residues in food.

Indexed as

alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic AcidCross-Sectional StudiesDietDietary ExposureEnvironmental MonitoringGermanyGlycineGlyphosateHerbicidesalpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic AcidGlycineGlyphosateHerbicidesBiomonitoringCorrelationFood consumptionGlyphosateHumanUrine

Identifiers

PMID32232512
PMCPMC7261737
OpenAlexW3013943097

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.