ReviewObstetrical & gynecological survey2020
Management of Anticoagulation in Pregnant Women With Mechanical Heart Valves.
Review in Obstetrical & gynecological survey, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- Maternal, Valvular and Foetal Outcomes of Pregnancy Following Aortic Valve Replacement.European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery · 2026Pooled it
- Management of Pulmonary Hypertension in Pregnancy.Current heart failure reports · 2025Review
- Perioperative management of a pregnant patient with a mechanical heart valve undergoing appendectomy: a case report.Annals of medicine and surgery (2012) · 2025Article
- Risk Factors of Thrombophilia-Related Mutations for Early and Late Pregnancy Loss.Medicina (Kaunas, Lithuania) · 2024Article
- Enoxaparin as an Anticoagulant in a Multipara with a Mechanical Mitral Valve: A Case Report.Journal of chest surgery · 2023Article
- Article
- Treasure to the mother and threat to the fetus: case report of warfarin-associated fetal intracranial hemorrhage and review of literature.The Journal of international medical research · 2023Review
- Pregnancy After Cardiac Surgery.Cureus · 2022Review
- Mitral valve-in-valve implantation during pregnancy.BMJ case reports · 2021Article
- Peripartum considerations for women with cardiac disease.Current opinion in anaesthesiology · 2021Review
- Mechanical heart valve thrombosis during pregnancy under nonZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
importanceMechanical heart valves (MHVs) pose significant thrombogenic risks to pregnant women and their fetuses, yet the choice of anticoagulation in this clinical setting remains unclear. Various therapeutic strategies carry distinct risk profiles that must be considered when making the decision about optimal anticoagulation.
objectiveWe sought to review existing data and offer recommendations for the anticoagulation of pregnant women with MHVs, as well as management of anticoagulation in the peripartum period. EVIDENCE ACQUISITION: We performed a literature review of studies examining outcomes in pregnant women receiving systemic anticoagulation for mechanical valves, and also reviewed data on the safety profiles of various anticoagulant strategies in the setting of pregnancy.
resultsWarfarin has been shown to increase rates of embryopathy and fetal demise, although it has traditionally been the favored anticoagulant in this setting. Low-molecular-weight heparin, when dosed appropriately with close therapeutic monitoring, has been shown to be safe for both mother and fetus.
conclusionsWe favor the use of low-molecular-weight heparin with appropriate dosing and monitoring for the anticoagulation of pregnant women with MHVs. Data suggest that this approach minimizes the thrombotic risk associated with the valve while also providing safe and effective anticoagulation that can be easily managed in the peripartum period.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.