Evidence map›Paper›PMID 32232470›Full record

ArticleJournal of pediatric psychology2020

Stress and the Home Environment in Caregivers of Children with Sickle Cell.

Taniya E Varughese, Catherine R Hoyt, Allison J L'Hotta, Princess A Ikemenogo, Seth G Howdeshell, Ashley J Housten, Regina A Abel, Allison A King

Registry-linked trialOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of pediatric psychology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06562439 (Early Identification and Intervention Of Developmental Delay Among Infants And Toddlers With Sickle Cell Disease Using the Sickle Cell Caregiver Collaboration for Child Development), which is not on this map. Cited by 8 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 2 pooled it
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06562439 nawithdrawnnot on this mapstarted 2025, after this paper: background citation

Early Identification and Intervention Of Developmental Delay Among Infants And Toddlers With Sickle Cell Disease Using the Sickle Cell Caregiver Collaboration for Child Development (SCCCD) Intervention

TypeinterventionalSponsorWashington University School of MedicineRan2025 to 2028Enrolled0ConditionsSickle Cell DiseaseArmsSickle Cell Collaboration for Child Development
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 2 syntheses or guidelines pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Observational
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Taniya E VarugheseProgram in Occupational Therapy, Washington University School of Medicine.
Catherine R HoytProgram in Occupational Therapy, Washington University School of Medicine.
Allison J L'HottaProgram in Occupational Therapy, Washington University School of Medicine.
Princess A IkemenogoMeharry Medical College.
Seth G HowdeshellDepartment of Medicine, University of Iowa Hospitals and Clinics.
Ashley J HoustenDivision of Public Health Sciences, Department of Surgery, Washington University School of Medicine.
Regina A AbelProgram in Occupational Therapy, Washington University School of Medicine.
Allison A KingProgram in Occupational Therapy, Division of Hematology and Oncology, Department of Pediatrics, Washington University School of Medicine, St. Louis Children's Hospital.
Meharry Medical College · USSt. Louis Children's Hospital · USUniversity of Iowa Hospitals and Clinics · US

Funding

(SCANS) Sickle Cell Anemia Neurodevelopmental Screening - Mentoring and Research in Patient Oriented ResearchK24HL148305 · NHLBI · WASHINGTON UNIVERSITY · PI Allison A King · 2019 to 2026
$706k
NHLBI NIH HHS K24 HL148305
6 · The paper itself

Abstract

objectiveCaregivers of young children with chronic illnesses are at high risk for elevated levels of stress and mental health symptoms. This study examined stress and mental health symptoms as well as the socioeconomic status (SES) and home environments of a cohort of caregivers of infants and toddlers with sickle cell disease (SCD).

methodsForty-two caregivers of infants and toddlers (aged 1-34 months) with SCD completed the Brief Symptom Inventory (BSI) and Parent Stress Index (PSI). The Home Observation for Measurement of the Environment (HOME) was used to assess family living environments.

resultsCompared to test norms, caregivers reported high levels of situational/demographic life stress [mean difference (MD) 5.7, p = .003] and child distractibility/hyperactivity (MD 3.62, p = .001) on the PSI. However, no significant differences in psychological symptoms of distress were noted on the BSI. Caregivers scored significantly lower than norms on PSI subdomains of acceptability (MD -1.88, p = .03), competence (MD -3.11, p = .002), depression (MD -3.94, p < .001), and the overall parent domain (MD -12.55, p = .005). Significant correlations were found between PSI scores and the HOME and between SES and the HOME.

conclusionCaregivers of infants and toddlers with SCD experience elevated levels of life stress but, in turn, endorse high acceptance of their child and self-competence in parenting. Although life stress may be high in this population, symptoms of psychological distress were not identified. Caregivers reporting elevated life and illness-specific stressors may benefit from environmental supports and interventions.

Indexed as

Anemia, Sickle CellCaregiversStress, PsychologicalChild, PreschoolHumansInfantParentingParentscaregivershome environmentsickle cell diseasesocioeconomic statusstress

Identifiers

PMID32232470
PMCPMC12104525
OpenAlexW3013611231

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.