Evidence map›Paper›PMID 32232169›Full record

ArticleEuropean stroke journal2020

Thrombolytic therapy in older acute ischemic stroke patients with gastrointestinal malignancy or recent bleeding.

Taku Inohara, Li Liang, Andrzej S Kosinski, Eric E Smith, Lee H Schwamm, Adrian F Hernandez, Deepak L Bhatt, Gregg C Fonarow, Eric D Peterson, Ying Xian

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European stroke journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Article
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 2 countries.

Taku InoharaDuke Clinical Research Institute, Duke University Medical Center, Durham, NC, USA.ORCID https://orcid.org/0000-0002-7889-2083
Li LiangDuke Clinical Research Institute, Duke University Medical Center, Durham, NC, USA.
Andrzej S KosinskiDuke Clinical Research Institute, Duke University Medical Center, Durham, NC, USA.
Eric E SmithDepartment of Clinical Neurosciences, Hotchkiss Brian Institute, University of Calgary, Calgary, Canada.
Lee H SchwammDepartment of Neurology, Massachusetts General Hospital, Boston, MA, USA.
Adrian F HernandezDuke Clinical Research Institute, Duke University Medical Center, Durham, NC, USA.
Deepak L BhattBrigham and Women's Hospital Heart and Vascular Center and Harvard Medical School, Boston, MA, USA.
Gregg C FonarowDivision of Cardiology, Ronald Reagan University of California, Los Angeles Medical Center, Los Angeles, CA, USA.
Eric D PetersonDuke Clinical Research Institute, Duke University Medical Center, Durham, NC, USA.
Ying XianDuke Clinical Research Institute, Duke University Medical Center, Durham, NC, USA.
Clinical Research Institute · USBrigham and Women's Hospital · USDuke University · USMassachusetts General Hospital · USUniversity of Calgary · CAUniversity of California, Los Angeles · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThere are limited data on the safety of intravenous recombinant tissue plasminogen activator (rtPA) for treating acute ischemic stroke in patients with gastrointestinal malignancy or recent gastrointestinal bleeding within 21 days of their index stroke.

aimsTo evaluate clinical outcomes in patients treated with rtPA for acute ischemic stroke who had gastrointestinal malignancy or recent gastrointestinal bleeding.

methodsWe identified patients who were treated with rtPA for acute ischemic stroke between 2/2009 and 12/2015 from the Get With The Guidelines-Stroke linked to Medicare claims data. Gastrointestinal malignancy and recent gastrointestinal bleeding were defined as any gastrointestinal malignancy hospitalisation within one year prior to acute ischemic stroke and gastrointestinal bleeding hospitalisation within 21 days prior to acute ischemic stroke, respectively. Outcomes of interest included in-hospital mortality and bleeding complications.

resultsAmong 40,396 patients aged 65 years or older treated with rtPA for acute ischemic stroke from 1522 sites (mean age [SD] 81.0 [8.1] years; 41.9% women), 136 (0.3%) had gastrointestinal malignancy (

conclusionsIn this observational cohort, we did not find increased risk of in-hospital mortality and bleeding in rtPA-treated patients with gastrointestinal malignancy or recent gastrointestinal bleeding.

Indexed as

contraindicationeligibility criteriaRecombinant tissue plasminogen activatorstrokethrombolysis

Identifiers

PMID32232169
PMCPMC7092738
OpenAlexW2971156316

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.