Evidence map›Paper›PMID 32232161›Full record

ArticleScience advances2020

The insulator functions of the

Olga Kyrchanova, Oksana Maksimenko, Airat Ibragimov, Vladimir Sokolov, Nikolay Postika, Maria Lukyanova, Paul Schedl, Pavel Georgiev

Open access · goldAbstract read
In one paragraph

Article in Science advances, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
3.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 49 citations in OpenAlex.

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  8. The N-Terminal Part ofInternational journal of molecular sciences · 2023
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  10. Transcriptional Readthrough Interrupts Boundary Function in Drosophila.International journal of molecular sciences · 2023
    Article
  11. Transcriptional read through interrupts boundary function in Drosophila.bioRxiv : the preprint server for biology · 2023
    Article
  12. Article
  13. Mechanisms of Interaction between Enhancers and Promoters in ThreeInternational journal of molecular sciences · 2023
    Review
  14. Article
  15. Review
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  19. Review
  20. GAGA factor: a multifunctional pioneering chromatin protein.Cellular and molecular life sciences : CMLS · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Olga KyrchanovaDepartment of the Control of Genetic Processes, Institute of Gene Biology Russian Academy of Sciences, 34/5 Vavilov St., Moscow 119334, Russia.ORCID 0000-0002-6249-0418
Oksana MaksimenkoCenter for Precision Genome Editing and Genetic Technologies for Biomedicine, Institute of Gene Biology, Russian Academy of Sciences, 34/5 Vavilov St., Moscow 119334, Russia.
Airat IbragimovCenter for Precision Genome Editing and Genetic Technologies for Biomedicine, Institute of Gene Biology, Russian Academy of Sciences, 34/5 Vavilov St., Moscow 119334, Russia.
Vladimir SokolovDepartment of the Control of Genetic Processes, Institute of Gene Biology Russian Academy of Sciences, 34/5 Vavilov St., Moscow 119334, Russia.
Nikolay PostikaDepartment of the Control of Genetic Processes, Institute of Gene Biology Russian Academy of Sciences, 34/5 Vavilov St., Moscow 119334, Russia.ORCID 0000-0002-2737-9781
Maria LukyanovaDepartment of the Control of Genetic Processes, Institute of Gene Biology Russian Academy of Sciences, 34/5 Vavilov St., Moscow 119334, Russia.
Paul SchedlDepartment of Molecular Biology, Princeton University, Princeton, NJ 08544, USA.
Pavel GeorgievDepartment of the Control of Genetic Processes, Institute of Gene Biology Russian Academy of Sciences, 34/5 Vavilov St., Moscow 119334, Russia.ORCID 0000-0002-6509-3194
Institute of Gene Biology · RUPrinceton University · US

Funding

Genetic regulatory mechanism in development and differentiationR35GM126975 · NIGMS · PRINCETON UNIVERSITY · PI SCHEDL, PAUL D · 2018 to 2022
$3.0M
NIGMS NIH HHS R35 GM126975
6 · The paper itself

Abstract

In mammals, a C2H2 zinc finger (C2H2) protein, CTCF, acts as the master regulator of chromosomal architecture and of the expression of Hox gene clusters. Like mammalian CTCF, the

Indexed as

Insulator ElementsAnimalsCCCTC-Binding FactorCYS2-HIS2 Zinc FingersDNA-Binding ProteinsDrosophilaDrosophila ProteinsGene Expression RegulationPhenotypeCCCTC-Binding FactorCTCF protein, DrosophilaDNA-Binding ProteinsDrosophila Proteins

Identifiers

PMID32232161
PMCPMC7096168
OpenAlexW3013793427

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.