ReviewBioelectronic medicine2020
Spinal cord stimulation in Parkinson's disease: a review of the preclinical and clinical data and future prospects.
Review in Bioelectronic medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04956770 (STIMO-PARKINSON), which is not on this map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
STIMO-PARKINSON: Study on Feasibility of Targeted Epidural Spinal Stimulation (TESS) to Improve Mobility in Patients With Parkinson's Disease
Who cites it
15 citing papers in PubMed, 32 citations in OpenAlex.
- Neural Network Connection Characteristics Between Motor Cortex and Spinal Cord During Rat Bipedal Walking.CNS neuroscience & therapeutics · 2026Article
- Feasibility and preliminary outcomes of spinal magnetic stimulation for functional constipation: a pilot randomized placebo-controlled trial.Annals of coloproctology · 2026Article
- Recent trends in spinal trauma management and research.Journal of clinical orthopaedics and trauma · 2024Article
- Towards non-invasive imaging through spinal-cord generated magnetic fields.Frontiers in medical technology · 2024Article
- Spinal cord stimulation for spinal cord injury - Where do we stand? A narrative review.Journal of clinical orthopaedics and trauma · 2023Article
- Review
- Effects of High Cervical Spinal Cord Stimulation on Gait Disturbance and Dysarthropneumophonia in Parkinson's Disease and Parkinson Variant of Multiple System Atrophy: A Case Series.Brain sciences · 2022Article
- Advances in DBS Technology and Novel Applications: Focus on Movement Disorders.Current neurology and neuroscience reports · 2022Review
- Controversies and Clinical Applications of Non-Invasive Transspinal Magnetic Stimulation: A Critical Review and Exploratory Trial in Hereditary Spastic Paraplegia.Journal of clinical medicine · 2022Article
- Deep brain stimulation in Parkinson's disease: state of the art and future perspectives.Arquivos de neuro-psiquiatria · 2022Review
- Gaps and roadmap of novel neuromodulation targets for treatment of gait in Parkinson's disease.NPJ Parkinson's disease · 2022Review
- Therapeutic Devices for Motor Symptoms in Parkinson's Disease: Current Progress and a Systematic Review of Recent Randomized Controlled Trials.Frontiers in aging neuroscience · 2022Review
- Freezing of Gait in Parkinson's Disease: Invasive and Noninvasive Neuromodulation.Neuromodulation : journal of the International Neuromodulation Society · 2021Review
- Spinal cord stimulation therapy for gait dysfunction in progressive supranuclear palsy patients.Journal of neurology · 2021Article
- On the Right Track to Treat Movement Disorders: Promising Therapeutic Approaches for Parkinson's and Huntington's Disease.Frontiers in aging neuroscience · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Parkinson's disease (PD) is a progressive neurodegenerative disease with an incidence of 0.1 to 0.2% over the age of 40 and a prevalence of over 1 million people in North America. The most common symptoms include tremor, bradykinesia, rigidity, pain, and postural instability, with significant impact in quality of life and mortality. To date there is ongoing research to determine the optimum therapy for PD. In this review we analyze the current data in the use of spinal cord stimulation (SCS) therapy for treatment for Parkinsonian symptoms. We specifically address waveform pattern, anatomic location and the role of spinal cord stimulation (SCS) as a salvage therapy after deep brain stimulation (DBS) therapy. We also outline current experimental evidence from preclinical research highlighting possible mechanisms of beneficial effects of SCS in this context. Though the use of SCS therapy is in its infancy for treatment of PD, the data points to an exciting area for ongoing research and exploration with positive outcomes from both cervical and thoracic tonic and BURSTDR spinal cord stimulation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.