ReviewBioelectronic medicine2018
Realizing flexible bioelectronic medicines for accessing the peripheral nerves - technology considerations.
Review in Bioelectronic medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 57 citations in OpenAlex.
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- An In Vivo Biostability Evaluation of ALD and Parylene-ALD Multilayers as Micro-Packaging Solutions for Small Single-Chip Implants.Small (Weinheim an der Bergstrasse, Germany) · 2025Article
- On the longevity and inherent hermeticity of silicon-ICs: evaluation of bare-die and PDMS-coated ICs after accelerated aging and implantation studies.Nature communications · 2025Article
- Accelerating neurotechnology development using an Agile methodology.Frontiers in neuroscience · 2024Review
- Recent Advancements in Bioelectronic Medicine: A Review.Current drug delivery · 2024Review
- Thin Film Encapsulation for LCP-Based Flexible Bioelectronic Implants: Comparison of Different Coating Materials Using Test Methodologies for Life-Time Estimation.Micromachines · 2022Article
- A Microclip Peripheral Nerve Interface (μcPNI) for Bioelectronic Interfacing with Small Nerves.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- Multilayer CVD graphene electrodes using a transfer-free process for the next generation of optically transparent and MRI-compatible neural interfaces.Microsystems & nanoengineering · 2022Article
- Optimized design of a hyperflexible sieve electrode to enhance neurovascular regeneration for a peripheral neural interface.Biomaterials · 2021Article
- A Focused Review of Neural Recording and Stimulation Techniques With Immune-Modulatory Targets.Frontiers in immunology · 2021Review
- Microtopographical patterns promote different responses in fibroblasts and Schwann cells: A possible feature for neural implants.Journal of biomedical materials research. Part A · 2021Article
- Bioelectronic Medicine: From Preclinical Studies on the Inflammatory Reflex to New Approaches in Disease Diagnosis and Treatment.Cold Spring Harbor perspectives in medicine · 2020Review
- Bioelectronic medicine: updates, challenges and paths forward.Bioelectronic medicine · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Patients suffering from conditions such as paralysis, diabetes or rheumatoid arthritis could in the future be treated in a personalised manner using bioelectronic medicines (BEms) (Nat Rev Drug Discov 13:399-400, 2013, Proc Natl Acad Sci USA 113:8284-9, 2016, J Intern Med 282:37-45, 2017). To deliver this personalised therapy based on electricity, BEms need to target various sites in the human body and operate in a closed-loop manner. The specific conditions and anatomy of the targeted sites pose unique challenges in the development of BEms. With a focus on BEms based on flexible substrates for accessing small peripheral nerves, this paper discusses several system-level technology considerations related to the development of such devices. The focus is mainly on miniaturisation and long-term operation. We present an overview of common substrate and electrode materials, related processing methods, and discuss assembly, miniaturisation and long-term stability issues.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.