ReviewBioelectronic medicine2018
Is-there a place for vagus nerve stimulation in inflammatory bowel diseases?
Review in Bioelectronic medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 47 citations in OpenAlex.
- The Microbiota-Gut-Brain Axis Across the Lifespan: From Neurodevelopment to Neurodegeneration.Journal of clinical medicine · 2026Review
- Molecular links between inflammatory bowel disease and Alzheimer's disease through immune signaling and inflammatory pathways.World journal of gastroenterology · 2025Review
- [Research progress on vagus nerve stimulation in the treatment of chronic pain].Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2025Review
- Enteric nervous system as a therapeutic target in gastrointestinal disorders.World journal of gastrointestinal pharmacology and therapeutics · 2025Article
- The Microbiota-Gut-Brain Axis in Autism: Associations, Causal Inference, and Interventions-A Narrative Review.Pathogens (Basel, Switzerland) · 2025Review
- High-fat and high-carbohydrate diets worsen the mouse brain susceptibility to damage produced by enterohemorrhagicHeliyon · 2024Article
- Mechanisms of Vagus Nerve Stimulation in Improving Motor Dysfunction After Stroke.Neuropsychiatric disease and treatment · 2024Review
- Neuromodulation for functional upper gastrointestinal diseases.Gut microbiota and integrative wellness · 2023Article
- Review
- Electrical neuromodulation therapy for inflammatory bowel disease.World journal of gastrointestinal pathophysiology · 2022Review
- Manipulation of the inflammatory reflex as a therapeutic strategy.Cell reports. Medicine · 2022Review
- Transcutaneous auricular vagus nerve stimulation (taVNS) for the treatment of pediatric nephrotic syndrome: a pilot study.Bioelectronic medicine · 2022Article
- Alzheimer's disease: An evolving understanding of noradrenergic involvement and the promising future of electroceutical therapies.Clinical and translational medicine · 2021Review
- Neuropathy and primary headaches affect different subgroups of inflammatory bowel disease patients.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021Article
- Strategies to Refine Gastric Stimulation and Pacing Protocols: Experimental and Modeling Approaches.Frontiers in neuroscience · 2021Review
- Bioelectronic Medicine: From Preclinical Studies on the Inflammatory Reflex to New Approaches in Disease Diagnosis and Treatment.Cold Spring Harbor perspectives in medicine · 2020Review
- Ultrasound Intra Body Multi Node Communication System for Bioelectronic Medicine.Sensors (Basel, Switzerland) · 2019Article
- Optogenetic Control of the Peripheral Nervous System.Cold Spring Harbor perspectives in medicine · 2019Review
- An Injectable Neural Stimulation Electrode Made from an In-Body Curing Polymer/Metal Composite.Advanced healthcare materials · 2019Article
- Therapeutic ultrasound attenuates DSS-induced colitis through the cholinergic anti-inflammatory pathway.EBioMedicine · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The vagus nerve (VN), the longest nerve of the organism that innervates the gastrointestinal tract, is a mixed nerve composed of 80% of afferent and 20% of efferent fibers. The VN has anti-inflammatory properties, in particular an anti-TNFα effect through the cholinergic anti-inflammatory pathway. The VN is a key component of the autonomic nervous system, i.e. the parasympathetic nervous system. An imbalance of the autonomic nervous system, as represented by a low vagal tone, is described in many diseases and has a pro-inflammatory role. Inflammatory bowel diseases (IBD) are chronic disorders of the gastro-intestinal tract where TNFα is a key cytokine. VN stimulation (VNS), classically used for the treatment of drug resistant epilepsy and depression, would be of interest in the treatment of IBD. We have recently reported in a 6 month follow-up pilot study that VNS improves active Crohn's disease. Preliminary data of another pilot study confirm this interest. Similarly, VNS has recently been reported to improve rheumatoid arthritis, another TNFα mediated disease. Bioelectronic Medicine, as represented by VNS, opens new therapeutic avenues in the treatment of such chronic inflammatory disorders. In the present manuscript, we will focus on the interest of VNS in IBD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.