ArticleFrontiers in cardiovascular medicine2020
Considerations for Using the Vasculature as a Coordinate System to Map All the Cells in the Human Body.
Article in Frontiers in cardiovascular medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 0 citations in OpenAlex.
- Vasculature segmentation in 3D hierarchical phase-contrast tomography images of human kidneys.Nature communications · 2026Pooled it
- Exploring endothelial cell environments across organs in spatially resolved omics data.bioRxiv : the preprint server for biology · 2025Article
- A multiscale vascular atlas of blood vessels supplying the urinary bladder of male and female mice.American journal of physiology. Renal physiology · 2025Article
- Constructing and Using Cell Type Populations of the Human Reference Atlas.bioRxiv : the preprint server for biology · 2025Article
- Comprehensive Single-Cell RNA Atlas of Human Laryngeal Normal, Preneoplastic, and Tumorigenic States.Clinical cancer research : an official journal of the American Association for Cancer Research · 2025Article
- Construction, Deployment, and Usage of the Human Reference Atlas Knowledge Graph.Scientific data · 2025Article
- Human BioMolecular Atlas Program (HuBMAP): 3D Human Reference Atlas construction and usage.Nature methods · 2025Article
- Construction, Deployment, and Usage of the Human Reference Atlas Knowledge Graph for Linked Open Data.bioRxiv : the preprint server for biology · 2025Article
- Functional tissue units in the Human Reference Atlas.Nature communications · 2025Article
- Human BioMolecular Atlas Program (HuBMAP): 3D Human Reference Atlas Construction and Usage.bioRxiv : the preprint server for biology · 2024Article
- Single-cell transcriptomic analyses of tumor microenvironment and molecular reprograming landscape of metastatic laryngeal squamous cell carcinoma.Communications biology · 2024Article
- Functional Tissue Units in the Human Reference Atlas.bioRxiv : the preprint server for biology · 2023Article
- A Roadmap for the Human Gut Cell Atlas.Nature reviews. Gastroenterology & hepatology · 2023Review
- Organ Mapping Antibody Panels: a community resource for standardized multiplexed tissue imaging.Nature methods · 2023Article
- Advances and prospects for the Human BioMolecular Atlas Program (HuBMAP).Nature cell biology · 2023Review
- 3D reconstruction of skin and spatial mapping of immune cell density, vascular distance and effects of sun exposure and aging.Communications biology · 2023Article
- Anatomical structures, cell types, and biomarkers of the healthy human blood vasculature.Scientific data · 2023Article
- Towards a clinically-based common coordinate framework for the human gut cell atlas: the gut models.BMC medical informatics and decision making · 2023Article
- Simplifying the Process of Going From Cells to Tissues Using Statistical Mechanics.Frontiers in physiology · 2022Article
- Where Is the Cystic Fibrosis Transmembrane Conductance Regulator?American journal of respiratory and critical care medicine · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Several ongoing international efforts are developing methods of localizing single cells within organs or mapping the entire human body at the single cell level, including the Chan Zuckerberg Initiative's Human Cell Atlas (HCA), and the Knut and Allice Wallenberg Foundation's Human Protein Atlas (HPA), and the National Institutes of Health's Human BioMolecular Atlas Program (HuBMAP). Their goals are to understand cell specialization, interactions, spatial organization in their natural context, and ultimately the function of every cell within the body. In the same way that the Human Genome Project had to assemble sequence data from different people to construct a complete sequence, multiple centers around the world are collecting tissue specimens from diverse populations that vary in age, race, sex, and body size. A challenge will be combining these heterogeneous tissue samples into a 3D reference map that will enable multiscale, multidimensional Google Maps-like exploration of the human body. Key to making alignment of tissue samples work is identifying and using a coordinate system called a Common Coordinate Framework (CCF), which defines the positions, or "addresses," in a reference body, from whole organs down to functional tissue units and individual cells. In this perspective, we examine the concept of a CCF based on the vasculature and describe why it would be an attractive choice for mapping the human body.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.