Evidence map›Paper›PMID 32232005›Full record

ArticleFrontiers in oncology2020

Gastric Cancer Cell-Derived Exosomal microRNA-23a Promotes Angiogenesis by Targeting PTEN.

Jiang Du, Yuan Liang, Ji Li, Jin-Ming Zhao, Xu-Yong Lin

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 73 citations in OpenAlex.

  1. Review
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  7. MicroRNA-Mediated Regulatory Networks inBiochemistry research international · 2025
    Review
  8. Review
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  10. Non-coding RNA in infantile hemangioma.Pediatric research · 2024
    Review
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  12. Article
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  18. Article
  19. Exosomes for angiogenesis induction in ischemic disorders.Journal of cellular and molecular medicine · 2023
    Review
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Jiang DuDepartment of Pathology, The First Affiliated Hospital and College of Basic Medical Science, China Medical University, Shenyang, China.
Yuan LiangMedical Oncology Department of Thoracic Cancer (2), Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang, China.
Ji LiDepartment of Pathology, The First Affiliated Hospital and College of Basic Medical Science, China Medical University, Shenyang, China.
Jin-Ming ZhaoDepartment of Pathology, The First Affiliated Hospital and College of Basic Medical Science, China Medical University, Shenyang, China.
Xu-Yong LinDepartment of Pathology, The First Affiliated Hospital and College of Basic Medical Science, China Medical University, Shenyang, China.
China Medical University · CNLiaoning Cancer Hospital & Institute · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hypoxia-exposed lung cancer-released exosomal microRNA-23a (miR-23a) has been shown to enhance angiogenesis as well as vascular permeability, contributing to the close correlation between exosomal miR-23a and tumorigenesis. The current study aimed to investigate whether gastric cancer (GC) cell-derived exosomal miR-23a could induce angiogenesis and to elucidate the potential mechanisms associated with the process. Differentially expressed miRNAs in GC were initially screened from the Gene Expression Omnibus database. Target genes were selected following miRNA-mRNA prediction and subsequently verified by dual luciferase reporter assay. RT-qPCR was conducted to detect miR-23a and PTEN expression in GC tissues, cells and exosomes. Human umbilical venous endothelial cells (HUVECs) were co-cultured with GC cell-derived exosomes to assess the angiogenesis mediated by exosomes

Indexed as

AKT pathwayangiogenesisexosomegastric cancermicroRNA-23aPTEN

Identifiers

PMID32232005
PMCPMC7082307
OpenAlexW3011555870

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.