ReviewFood safety (Tokyo, Japan)2016
Aflatoxin Exposure and Associated Human Health Effects, a Review of Epidemiological Studies.
Review in Food safety (Tokyo, Japan), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
82 citing papers in PubMed, 4 syntheses or guidelines pooled it, 236 citations in OpenAlex.
- Workplace exposure to aflatoxins & its health effects: A systematic review.The Indian journal of medical research · 2025Pooled it
- Incidence and mortality of acute aflatoxicosis: A systematic review.Environment international · 2025Pooled it
- Level of exposure to aflatoxins during pregnancy and its association with adverse birth outcomes in Africa: a meta-analysis.International health · 2024Pooled it
- A systematic review with meta-analysis of the relation of aflatoxin B1 to growth impairment in infants/children.BMC pediatrics · 2023Pooled it
- Trial
- Aflatoxin occurrence in retail rice and rice-derived products from Bangladesh: An evaluation of dietary exposure and related health risks.Toxicology reports · 2026Article
- Determinants of serum aflatoxin B1 exposure among pregnant women in coastal Kenya: a cross-sectional study in Kwale County.Tropical medicine and health · 2026Article
- Review
- Identification and Detection of AflatoxigenicToxins · 2026Review
- Aflatoxin exposure and health impacts: global burden and advances in detection technologies.Genes and environment : the official journal of the Japanese Environmental Mutagen Society · 2026Review
- mRNA Rather than Protein Expression of Hepatic Selenoprotein H is More Sensitive to Short-term Low Aflatoxin BBiological trace element research · 2026Article
- Smallholder farmers' knowledge, practices and dietary responses to aflatoxin contamination in Baringo county, Kenya.Mycotoxin research · 2026Article
- Review
- Alleviation of Aflatoxin B1-Induced Hepatic Damage by Propolis: Effects on Inflammation, Apoptosis, and Cytochrome P450 Enzyme Expression.Current issues in molecular biology · 2026Article
- Mechanistic evidence and assumptions in mycotoxin-gut interaction.Frontiers in fungal biology · 2026Article
- Early Childhood Dietary Exposure of Aflatoxins and Fumonisins in Tanzania: Role in Child Stunting and Possible Interventions (2003-2024).Food science & nutrition · 2025Review
- Knowledge structure and evolution of masked mycotoxin research in Sub-Saharan Africa: A systematic review and network analysis approach.Toxicon: X · 2025Review
- Analysis of Reported Aflatoxin Levels in EU's Rapid Alert System for Food and Feed (RASFF) Notifications.Foods (Basel, Switzerland) · 2025Article
- The aflatoxin BNAR cancer · 2025Article
- Aflatoxin Exposure in Immunocompromised Patients: Current State and Future Perspectives.Toxins · 2025Review
22 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aflatoxins are fungal toxins that possess acute life threatening toxicity, carcinogenic properties and other potential chronic adverse effects. Dietary exposure to aflatoxins is considered a major public health concern, especially for subsistence farming communities in sub-Saharan Africa and South Asia, where dietary staple food crops such as groundnuts and maize are often highly contaminated with aflatoxin due to hot and humid climates and poor storage, together with low awareness of risk and lack of enforcement of regulatory limits. Biomarkers have been developed and applied in many epidemiological studies assessing aflatoxin exposure and the associated health effects in these high-risk population groups. This review discusses the recent epidemiological evidence for aflatoxin exposure, co-exposure with other mycotoxins and associated health effects in order to provide evidence on risk assessment, and highlight areas where further research is necessary. Aflatoxin exposure can occur at any stage of life and is a major risk factor for hepatocellular carcinoma, especially when hepatitis B infection is present. Recent evidence suggests that aflatoxin may be an underlying determinant of stunted child growth, and may lower cell-mediated immunity, thereby increasing disease susceptibility. However, a causal relationship between aflatoxin exposure and these latter adverse health outcomes has not been established, and the biological mechanisms for these have not been elucidated, prompting further research. Furthermore, there is a dearth of information regarding the health effects of co-exposure to aflatoxin with other mycotoxins. Recent developments of biomarkers provide opportunities for important future research in this area.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.