ArticleNature photonics2019
Wavelength-encoded laser particles for massively multiplexed cell tagging.
Article in Nature photonics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
54 citing papers in PubMed, 173 citations in OpenAlex.
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- Two-Photon 3D Printing of Functional Microstructures Inside Living Cells.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- When Matter Builds Itself: Blueprints from Life to Materials.Nano letters · 2026Review
- Liquid photonic-molecule microlasers for ultrasensitive biosensing.Nature communications · 2026Article
- Nanometer-Precision Tracking of Adipocyte Dynamics via Single Lipid Droplet Whispering-Gallery Optical Resonances.ACS sensors · 2026Article
- Encoded Microspheres in Multiplex Detection of Mycotoxins and Other Analytes.Foods (Basel, Switzerland) · 2026Review
- Whispering-gallery-mode resonators for detection and classification of free-flowing nanoparticles and cells through photoacoustic signatures.Light, science & applications · 2025Article
- Wideband Tuning and Deep-Tissue Spectral Detection of Indium Phosphide Nano-Laser Particles.Advanced materials (Deerfield Beach, Fla.) · 2025Article
- Topological nanorainbow laser.Science advances · 2025Article
- Optically-driven organic nano-step actuator for reconfigurable photonic circuits.Nature communications · 2025Article
- Biophotonic (nano)structures: from fundamentals to emerging applications.RSC advances · 2025Review
- Noble Metal Coating on Perovskite Microcrystals for Robust and Plasmonic Lasing Applications.Advanced optical materials · 2025Article
- Colloidal-quantum-dot nanolaser oscillating at a bound-state-in-the-continuum with planar surface topography for a highNanophotonics (Berlin, Germany) · 2025Article
- Large-scale combinatorial optical barcoding of cells with laser particles.Light, science & applications · 2025Article
- DNA Sensing with Whispering Gallery Mode Microlasers.Nano letters · 2025Article
- Overcoming fixation and permeabilization challenges in flow cytometry by optical barcoding and multi-pass acquisition.Cytometry. Part A : the journal of the International Society for Analytical Cytology · 2024Article
- Plasmonic Hinge Modes in Metal-Coated Nanolasers.Nano letters · 2024Article
- Single-cell laser emitting cytometry for label-free nucleolus fingerprinting.Nature communications · 2024Article
- Overcoming fixation and permeabilization challenges in flow cytometry by optical barcoding and multi-pass acquisition.bioRxiv : the preprint server for biology · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 2 institutions in 3 countries.
Funding
Abstract
Large-scale single-cell analyses have become increasingly important given the role of cellular heterogeneity in complex biological systems. However, no current techniques enable optical imaging of uniquely-tagged individual cells. Fluorescence-based approaches can only distinguish a small number of distinct cells or cell groups at a time because of spectral crosstalk between conventional fluorophores. Here we investigate large-scale cell tracking using intracellular laser particles as imaging probes that emit coherent laser light with a characteristic wavelength. Made of silica-coated semiconductor microcavities, these laser particles have single-mode emission over a broad range from 1170 to 1580 nm with sub-nm linewidths, enabling massive spectral multiplexing. We explore the stability and biocompatibility of these probes in vitro and their utility for wavelength-multiplexed cell tagging and imaging. We demonstrate real-time tracking of thousands of individual cells in a 3D tumour model over several days showing different behavioural phenotypes.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.