ArticleFrontiers in genetics2020
Exploring Phenotypes for Disease Resilience in Pigs Using Complete Blood Count Data From a Natural Disease Challenge Model.
Article in Frontiers in genetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 36 citations in OpenAlex.
- Genome-Wide Association Studies for 24 Hematological Traits in Production Pigs Before and After Weaning.Animal genetics · 2026Article
- Haematopoietic Traits in Indigenous and Modern Pig Breeds Are Modulated by Housing System and Developmental Stage.Animal genetics · 2026Article
- Insights into pig resilience: the Microbiome-genetic connection.Porcine health management · 2026Review
- Genetic correlations of environmental sensitivity based on daily feed intake perturbations with economically important traits in a male pig line.Genetics, selection, evolution : GSE · 2025Article
- Genetic factors for hematological traits in pigs.Animal genetics · 2025Review
- The potential probiotic role of Lacticaseibacillus rhamnosus on growth performance, gut health, and immune responses of weaned pigs.Journal of animal science · 2025Article
- Selection for Resilience in Livestock Production Systems.International journal of molecular sciences · 2024Review
- Size matters: lower body weight pigs have a different response to immune challenge and amino acids supplementation above the estimated requirement compared to heavy pigs.Journal of animal science · 2024Article
- Genetic determinism of sensitivity to environmental challenges using daily feed intake records in three lines of pigs.Journal of animal science · 2024Article
- Inheritance of feed intake-based resilience traits and their correlation with production traits in Finnish pig breeds.Journal of animal science · 2024Article
- Exploration of plasma metabolite levels in healthy nursery pigs in response to environmental enrichment and disease resilience.Journal of animal science · 2023Article
- Identification of intestinal and fecal microbial biomarkers using a porcine social stress model.Frontiers in microbiology · 2023Article
- GWAS and genetic and phenotypic correlations of plasma metabolites with complete blood count traits in healthy young pigs reveal implications for pig immune response.Frontiers in molecular biosciences · 2023Article
- Breeding for disease resilience: opportunities to manage polymicrobial challenge and improve commercial performance in the pig industry.CABI agriculture and bioscience · 2022Review
- Heritability and genetic correlations of plasma metabolites of pigs with production, resilience and carcass traits under natural polymicrobial disease challenge.Scientific reports · 2021Article
- A Methodology to Quantify Resilience in Growing Pigs.Animals : an open access journal from MDPI · 2021Article
- Quantitative analysis of the blood transcriptome of young healthy pigs and its relationship with subsequent disease resilience.BMC genomics · 2021Article
- Article
- Why breed disease-resilient livestock, and how?Genetics, selection, evolution : GSE · 2020Review
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Disease resilience is a valuable trait to help manage infectious diseases in livestock. It is anticipated that improved disease resilience will sustainably increase production efficiency, as resilient animals maintain their performance in the face of infection. The objective of this study was to identify phenotypes related to disease resilience using complete blood count (CBC) data from a wean-to-finish natural disease challenge model, established to mimic the disease pressure caused by many common pathogens at the commercial level of pig production. In total, 2433 F1 crossbred (Landrace × Yorkshire) barrows that went through the natural disease challenge model were classified into four groups (resilient, average, susceptible, and dead) based on their divergent responses in terms of growth and individual treatment. Three sets of blood samples for CBC analysis were drawn at 2-weeks before, and at 2- and 6-weeks after the challenge: Blood 1, Blood 3, and Blood 4 respectively. CBC of Blood 1 taken from healthy pigs before challenge did not show differences between groups. However, resilient animals were found to be primed to initiate a faster adaptive immune response and recover earlier following infection, with greater increases of lymphocyte concentration from Blood 1 to Blood 3 and for hemoglobin concentration and hematocrit from Blood 3 to Blood 4, but a lower neutrophil concentration from Blood 3 to Blood 4 than in susceptible and dead animals (
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