Evidence map›Paper›PMID 32231671›Full record

ArticleFrontiers in immunology2020

ANP32B Deficiency Protects Mice From Lethal Influenza A Virus Challenge by Dampening the Host Immune Response.

Sebastian Beck, Martin Zickler, Vinícius Pinho Dos Reis, Thomas Günther, Adam Grundhoff, Patrick T Reilly, Tak W Mak, Stephanie Stanelle-Bertram, Gülşah Gabriel

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
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  4. Article
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  8. Host Cell Factors That Interact with Influenza Virus Ribonucleoproteins.Cold Spring Harbor perspectives in medicine · 2021
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Sebastian BeckViral Zoonosis - One Health, Heinrich Pette Institute, Leibniz Institute for Experimental Virology, Hamburg, Germany.
Martin ZicklerViral Zoonosis - One Health, Heinrich Pette Institute, Leibniz Institute for Experimental Virology, Hamburg, Germany.
Vinícius Pinho Dos ReisViral Zoonosis - One Health, Heinrich Pette Institute, Leibniz Institute for Experimental Virology, Hamburg, Germany.
Thomas GüntherViral Zoonosis - One Health, Heinrich Pette Institute, Leibniz Institute for Experimental Virology, Hamburg, Germany.
Adam GrundhoffViral Zoonosis - One Health, Heinrich Pette Institute, Leibniz Institute for Experimental Virology, Hamburg, Germany.
Patrick T ReillyInstitut Clinique de la Souris, University of Strasbourg, Illkirch-Graffenstaden, France.
Tak W MakUniversity Health Network, Toronto, ON, Canada.
Stephanie Stanelle-BertramViral Zoonosis - One Health, Heinrich Pette Institute, Leibniz Institute for Experimental Virology, Hamburg, Germany.
Gülşah GabrielViral Zoonosis - One Health, Heinrich Pette Institute, Leibniz Institute for Experimental Virology, Hamburg, Germany.
Leibniz Institute of Virology (LIV) · DEUniversité de Strasbourg · FRUniversity Health Network · CAUniversity of Veterinary Medicine Hannover, Foundation · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Deciphering complex virus-host interactions is crucial for pandemic preparedness. In this study, we assessed the impact of recently postulated cellular factors ANP32A and ANP32B of influenza A virus (IAV) species specificity on viral pathogenesis in a genetically modified mouse model. Infection of ANP32A

Indexed as

AnimalsCell Cycle ProteinsDisease ResistanceGene Expression ProfilingHeLa CellsHumansImmune ToleranceImmunityImmunity, InnateInfluenza A virusInfluenza, HumanMiceMice, Inbred C57BLMice, KnockoutNerve Tissue ProteinsNuclear ProteinsAnp32b protein, mouseCell Cycle ProteinsNerve Tissue ProteinsNuclear ProteinsANP32AANP32Bantiviral immunityinfluenza A viruspathogenesis

Identifiers

PMID32231671
PMCPMC7083139
OpenAlexW3012498841

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.