Evidence map›Paper›PMID 32231591›Full record

ArticleFrontiers in physiology2020

Lauren G Douma, Kristen Solocinski, Sarah H Masten, Dominique H Barral, Sarah J Barilovits, Lauren A Jeffers, Kareme D Alder, Ravi Patel, Charles S Wingo, Kevin D Brown and 2 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.6field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Review
  3. Recent advances in understanding the kidney circadian clock mechanism.American journal of physiology. Renal physiology · 2024
    Review
  4. Circadian gene expression in mouse renal proximal tubule.American journal of physiology. Renal physiology · 2023
    Article
  5. Article
  6. Review
  7. Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Lauren G DoumaDepartment of Medicine, University of Florida, Gainesville, FL, United States.
Kristen SolocinskiDepartment of Medicine, University of Florida, Gainesville, FL, United States.
Sarah H MastenDepartment of Medicine, University of Florida, Gainesville, FL, United States.
Dominique H BarralDepartment of Medicine, University of Florida, Gainesville, FL, United States.
Sarah J BarilovitsDepartment of Medicine, University of Florida, Gainesville, FL, United States.
Lauren A JeffersDepartment of Biochemistry, Cell and Developmental Biology, Emory University, Atlanta, GA, United States.
Kareme D AlderYale University School of Medicine, New Haven, CT, United States.
Ravi PatelDepartment of Medicine, University of Florida, Gainesville, FL, United States.
Charles S WingoDepartment of Medicine, University of Florida, Gainesville, FL, United States.
Kevin D BrownDepartment of Biochemistry and Molecular Biology, University of Florida, Gainesville, FL, United States.
Brian D CainDepartment of Biochemistry and Molecular Biology, University of Florida, Gainesville, FL, United States.
Michelle L GumzDepartment of Medicine, University of Florida, Gainesville, FL, United States.
University of Florida · USEmory University · USYale University · US

Funding

University of Florida Older Americans Independence Center (OAIC)P30AG028740 · NIA · UNIVERSITY OF FLORIDA · PI Peihua Qiu · 2007 to 2026
$22.8M
MEDICAL SCIENTIST TRAINING PROGRAMT32GM008169 · NIGMS · EMORY UNIVERSITY · PI GROSS, ROBERT E · 1987 to 2021
$20.3M
REnal TrAIning & reteNtion (RETAIN) ProgramT32DK104721 · NIDDK · UNIVERSITY OF FLORIDA · PI SEGAL, MARK S., WOOD, CHARLES E · 2015 to 2019
$1.6M
Per1 and the kidney clock in hypertensionR01DK109570 · NIDDK · UNIVERSITY OF FLORIDA · PI GUMZ, MICHELLE L · 2017 to 2021
$1.5M
Novel mechanism to target the endothelin axis in aging and CKDR21AG052861 · NIA · UNIVERSITY OF FLORIDA · PI GUMZ, MICHELLE L · 2017 to 2018
$419k
NIA NIH HHS P30 AG028740NIA NIH HHS R21 AG052861NIDDK NIH HHS R01 DK109570NIDDK NIH HHS T32 DK104721NIGMS NIH HHS T32 GM008169
6 · The paper itself

Abstract

Endothelin-1 (ET-1) is a peptide hormone that functions as a vasoconstrictor in the vasculature, whereas in the collecting duct of the kidney it exerts blood pressure-lowering effects via natriuretic actions. Aberrant ET-1 signaling is associated with several pathological states including hypertension and chronic kidney disease. ET-1 expression is regulated largely through transcriptional control of the gene that encodes ET-1,

Indexed as

circadian rhythmCRISPRkidneylong non-coding RNAproximal tubule cells

Identifiers

PMID32231591
PMCPMC7082230
OpenAlexW3012448790

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.