ArticleNature neuroscience2020
Dissociable roles of ventral pallidum neurons in the basal ganglia reinforcement learning network.
Article in Nature neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 43 citations in OpenAlex.
- Beyond the brake: The subthalamic nucleus predominantly facilitates action in non-human primates.Progress in neurobiology · 2026Article
- Ventral pallidum GABA neuron inhibition augments context-appropriate defensive responses to learned threat cues.Neurobiology of stress · 2026Article
- Beyond the Brake: the Subthalamic Nucleus Predominantly Facilitates Action in Non-human Primates.bioRxiv : the preprint server for biology · 2025Article
- Paraventricular thalamic inputs to the ventral pallidum shape reward seeking during threat and fear responding in extinction.Behavioral neuroscience · 2025Article
- Excitatory drive to the globus pallidus external segment facilitates action initiation in non-human primates.Current biology : CB · 2025Article
- Contribution of glutamatergic projections to neurons in the nonhuman primate substantia nigra pars reticulata for reactive inhibition.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Predictive reward-prediction errors of climbing fiber inputs integrate modular reinforcement learning with supervised learning.PLoS computational biology · 2025Article
- Altered effective connectivity in Parkinson's disease patients with rapid eye movement sleep behavior disorder: a resting-state functional magnetic resonance imaging study and support vector machine analysis.Quantitative imaging in medicine and surgery · 2025Article
- DMN network and neurocognitive changes associated with dissociative symptoms in major depressive disorder: a research protocol.Frontiers in psychiatry · 2025Article
- Contribution of glutamatergic projections to neurons in the nonhuman primate lateral substantia nigra pars reticulata for the reactive inhibition.bioRxiv : the preprint server for biology · 2024Article
- Involvement of Neurons in the Nonhuman Primate Anterior Striatum in Proactive Inhibition.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Ventral Pallidum Neurons Are Necessary to Generalize and Express Fear-Related Responding in a Minimal Threat Setting.eNeuro · 2024Article
- Involvement of neurons in the non-human primate anterior striatum in proactive inhibition.bioRxiv : the preprint server for biology · 2024Article
- Optogenetic inhibition of the caudal substantia nigra inflates behavioral responding to uncertain threat and safety.Behavioral neuroscience · 2023Article
- Selective encoding of reward predictions and prediction errors by globus pallidus subpopulations.Current biology : CB · 2023Article
- Activation of Ventral Pallidum CaMKIIa-Expressing Neurons Promotes Wakefulness.Neurochemical research · 2023Article
- Optogenetic inhibition of the caudal substantia nigra inflates behavioral responding to uncertain threat and safety.bioRxiv : the preprint server for biology · 2023Article
- Ventral pallidal regulation of motivated behaviors and reinforcement.Frontiers in neural circuits · 2023Review
- Ventral pallidum GABA neurons bidirectionally control opioid relapse across rat behavioral models.Addiction neuroscience · 2022Article
- Threat and Bidirectional Valence Signaling in the Nucleus Accumbens Core.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Reinforcement learning models treat the basal ganglia (BG) as an actor-critic network. The ventral pallidum (VP) is a major component of the BG limbic system. However, its precise functional roles within the BG circuitry, particularly in comparison to the adjacent external segment of the globus pallidus (GPe), remain unexplored. We recorded the spiking activity of VP neurons, GPe cells (actor) and striatal cholinergic interneurons (critic) while monkeys performed a classical conditioning task. Here, we report that VP neurons can be classified into two distinct populations. The persistent population displayed sustained activation following visual cue presentation, was correlated with monkeys' behavior and showed uncorrelated spiking activity. The transient population displayed phasic synchronized responses that were correlated with the rate of learning and the reinforcement learning model's prediction error. Our results suggest that the VP is physiologically different from the GPe and identify the transient VP neurons as a BG critic.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.