Evidence map›Paper›PMID 32231334›Full record

ArticleNature biotechnology2020

Genetic circuit design automation for the gut resident species Bacteroides thetaiotaomicron.

Mao Taketani, Jianbo Zhang, Shuyi Zhang, Alexander J Triassi, Yu-Ja Huang, Linda G Griffith, Christopher A Voigt

Erratum issuedAbstract read
In one paragraph

Article in Nature biotechnology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 71 papers.

0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

71 citing papers in PubMed.

  1. Review
  2. Review
  3. Formic acid released by intratumoralActa pharmaceutica Sinica. B · 2026
    Article
  4. Article
  5. Programming Next-Generation Synthetic Biosensors by Genetic Circuit Design.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  6. Review
  7. Article
  8. Probiotic-Based Materials as Living Therapeutics.Advanced materials (Deerfield Beach, Fla.) · 2026
    Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Review
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Review
  20. Phage-delivered CRISPRi enables bacterial biocomputation.Synthetic biology (Oxford, England) · 2025
    Review

11 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Mao TaketaniDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
Jianbo ZhangDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID http://orcid.org/0000-0003-3526-4586
Shuyi ZhangDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
Alexander J TriassiDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID http://orcid.org/0000-0001-6703-1694
Yu-Ja HuangDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
Linda G GriffithDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
Christopher A VoigtDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA. cavoigt@gmail.com.ORCID http://orcid.org/0000-0003-0844-4776

Funding

MIT Center for Integrative Synthetic BiologyP50GM098792 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI WEISS, RON · 2013 to 2017
$11.0M
GuMI: New In Vitro Platforms to Parse the Human Gut Epithelial-Microbiome-Immune AxisR01EB021908 · NIBIB · NORTHEASTERN UNIVERSITY · PI CARRIER, REBECCA L, GRIFFITH, LINDA G · 2016 to 2020
$5.2M
NIBIB NIH HHS R01 EB021908NIGMS NIH HHS P50 GM098792
6 · The paper itself

Abstract

Bacteroides thetaiotaomicron is a human-associated bacterium that holds promise for delivery of therapies in the gut microbiome

Indexed as

AutomationGene Regulatory NetworksBacteroides thetaiotaomicronCRISPR-Cas SystemsGastrointestinal MicrobiomeHumansRNA, Guide, CRISPR-Cas SystemsTranscription, GeneticRNA, Guide, CRISPR-Cas Systems

Identifiers

PMID32231334
PMCPMC8922546

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.