Evidence map›Paper›PMID 32231306›Full record

ArticleNature cell biology2020

RNA helicase DDX21 mediates nucleotide stress responses in neural crest and melanoma cells.

Cristina Santoriello, Audrey Sporrij, Song Yang, Ryan A Flynn, Telmo Henriques, Bilguujin Dorjsuren, Eugenia Custo Greig, Wyatt McCall, Meredith E Stanhope, Maurizio Fazio and 10 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature cell biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 66 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 6 institutions in 1 country.

Cristina Santoriello *Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.
Audrey Sporrij *Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.
Song YangDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.
Ryan A FlynnDepartment of Chemistry, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0001-5013-0442
Telmo HenriquesDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.
Bilguujin DorjsurenDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.
Eugenia Custo GreigDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.
Wyatt McCallDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.
Meredith E StanhopeDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.
Maurizio FazioDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.ORCID http://orcid.org/0000-0003-0083-6601
Michael SuperdockDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.ORCID http://orcid.org/0000-0003-4165-4425
Asher LichtigDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.
Isaac AdattoDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.
Brian J AbrahamWhitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID http://orcid.org/0000-0001-8085-3027
Marian KalocsayLaboratory of Systems Pharmacology, Harvard Medical School, Boston, MA, USA.
Michael JurynecDepartment of Orthopedics, University of Utah, Salt Lake City, UT, USA.
Yi ZhouDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.
Karen AdelmanDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.
Eliezer CaloDepartment of Biology and Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.
Leonard I ZonDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA. leonard.zon@enders.tch.harvard.edu.ORCID http://orcid.org/0000-0003-0860-926X
Harvard University · USBoston Children's Hospital · USMassachusetts Institute of Technology · USStanford University · USUniversity of Utah · USWhitehead Institute for Biomedical Research · US

Funding

TELOMERASE INACTIVATION BY RNASE L SIGNALS CELL DEATHP01CA062220 · NCI · CLEVELAND CLINIC LERNER COM-CWRU · PI LI, XIAOXIA, STARK, GEORGE ROBERT · 1994 to 2020
$35.6M
TRANSLATIONAL PHARMACOLOGY COREP50GM107618 · NIGMS · HARVARD MEDICAL SCHOOL · PI GOLAN, DAVID E. · 2014 to 2018
$10.8M
Cancer Biology in the ZebrafishR01CA103846 · NCI · CHILDREN'S HOSPITAL BOSTON · PI ZON, LEONARD IRA · 2003 to 2022
$7.5M
NCI NIH HHS P01 CA062220NCI NIH HHS R01 CA103846NIGMS NIH HHS P50 GM107618
6 · The paper itself

Abstract

The availability of nucleotides has a direct impact on transcription. The inhibition of dihydroorotate dehydrogenase (DHODH) with leflunomide impacts nucleotide pools by reducing pyrimidine levels. Leflunomide abrogates the effective transcription elongation of genes required for neural crest development and melanoma growth in vivo

Indexed as

AnimalsCell Line, TumorDEAD-box RNA HelicasesDihydroorotate DehydrogenaseEmbryo, NonmammalianGene Expression Regulation, DevelopmentalHumansLeflunomideMelanocytesNeural CrestNucleotidesOxidoreductases Acting on CH-CH Group DonorsPhosphoproteinsProgesteroneProtein BindingReceptors, ProgesteroneDDX1 protein, humanddx21 protein, zebrafishDEAD-box RNA HelicasesDihydroorotate DehydrogenaseLeflunomideNucleotidesOxidoreductases Acting on CH-CH Group DonorsPhosphoproteinsProgesteroneReceptors, ProgesteroneTranscription FactorsZebrafish Proteins

Identifiers

PMID32231306
PMCPMC7185069
OpenAlexW3013336903

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.