ArticleNature immunology2020
Sestrins induce natural killer function in senescent-like CD8
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In one paragraph
Article in Nature immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 165 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
165citing papers in PubMed, 1 pooled it
12.0field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
165 citing papers in PubMed, 1 synthesis or guideline pooled it, 234 citations in OpenAlex.
- Immunosenescence Study of T Cells: A Systematic Review.Frontiers in immunology · 2020Pooled it
- Harnessing the NKG2D immune surveillance pathway using engineered T-cells for the treatment of human disease.Human vaccines & immunotherapeutics · 2026Review
- T cell senescence and exhaustion: molecular mechanisms and immune rejuvenation for cancer immunotherapy.Signal transduction and targeted therapy · 2026Review
- The immunology behind inflammaging-causes, sources, and mechanisms.The Journal of allergy and clinical immunology · 2026Review
- Persistent cytolytic CD8Cell reports. Medicine · 2026Article
- Targeted clearance of senescent cells alleviates alcohol-associated liver disease by restoring cellular function and immune balance.GeroScience · 2026Article
- Single-cell map of the healthy human immune system across the lifespan reveals unique infant immune signatures.Nature communications · 2026Article
- Regulation of T Cell Senescence in Health and Diseases.Immune network · 2026Review
- Bat-Inspired Longevity: Immune Damage Management and Nutritional Modulation for Healthy Aging.International journal of molecular sciences · 2026Review
- Lifestyle intervention is associated with attenuation of ER stress/inflammation and enhancement of naive immune cell identity in older adults with metabolic disease.bioRxiv : the preprint server for biology · 2026Article
- Review
- Review
- Age-independent and targetable transcription factor networks regulating CD8Cell reports · 2026Article
- Vδ1 T-cell subset appears to be responsive to PD-1 blockade therapy and is associated with survival in melanoma.Journal for immunotherapy of cancer · 2026Article
- The Hidden Pathway: Membrane Vitamin D Receptor Deficiency and T-Cell Senescence in Pediatric Atopic Dermatitis - A Retrospective and Cross-Sectional Investigation.Journal of asthma and allergy · 2026Article
- Dual roles of immunosenescence in cancer immunotherapy.Frontiers in immunology · 2026Review
- Interaction between NKG2D and its ligands MICA/B activates the DAP12/SYK/p53/p21 axis to drive pulmonary fibrosis.Frontiers in immunology · 2026Article
- Senescent CD8 T Effector Memory Cells are Functionally Impaired, Enriched in Aging and Disease, and a Barrier to Immunotherapy.bioRxiv : the preprint server for biology · 2025Article
- CD8⁺ T cell heterogeneity in aging: insights from single-cell profiling.Immunity & ageing : I & A · 2025Review
- Immunosenescence in aging and neurodegenerative diseases: evidence, key hallmarks, and therapeutic implications.Translational neurodegeneration · 2025Review
105 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
23 authors at 12 institutions in 5 countries.
Branca I Pereira *Division of Infection and Immunity, University College London, London, UK.
Roel P H De Maeyer *Division of Infection and Immunity, University College London, London, UK.ORCID http://orcid.org/0000-0003-4041-0867
Luciana P Covre *Division of Infection and Immunity, University College London, London, UK.ORCID http://orcid.org/0000-0001-5877-0137
Djamel Nehar-Belaid *The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.ORCID http://orcid.org/0000-0001-6002-5021
Alessio LannaDivision of Infection and Immunity, University College London, London, UK.
Sophie WardDepartment of Medicine, Imperial College London, London, UK.
Radu MarchesThe Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.
Emma S ChambersDivision of Infection and Immunity, University College London, London, UK.ORCID http://orcid.org/0000-0003-0990-8835
Daniel C O GomesNúcleo de Doenças Infecciosas, Universidade Federal do Espírito Santo, Vitória, Brazil.
Natalie E RiddellDivision of Infection and Immunity, University College London, London, UK.
Mala K MainiDivision of Infection and Immunity, University College London, London, UK.ORCID http://orcid.org/0000-0001-6384-1462
Vitor H TeixeiraLungs for Living Research Centre, UCL Respiratory, University College London, London, UK.ORCID http://orcid.org/0000-0003-0090-861X
Samuel M JanesLungs for Living Research Centre, UCL Respiratory, University College London, London, UK.ORCID http://orcid.org/0000-0002-6634-5939
Derek W GilroyDivision of Medicine, University College London, London, UK.ORCID http://orcid.org/0000-0003-3476-0844
Anis LarbiSingapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Biopolis, Singapore, Singapore.
Neil A MabbottRoslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0001-7395-1796
Duygu UcarThe Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.ORCID http://orcid.org/0000-0002-9772-3066
George A KuchelUniversity of Connecticut Center on Aging, University of Connecticut, Farmington, CT, USA.ORCID http://orcid.org/0000-0001-8387-7040
Sian M HensonWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Jessica StridDepartment of Medicine, Imperial College London, London, UK.ORCID http://orcid.org/0000-0003-3690-2201
Jun H LeeDepartment of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-2200-6011
Jacques BanchereauThe Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.ORCID http://orcid.org/0000-0003-3535-7221
Arne N AkbarDivision of Infection and Immunity, University College London, London, UK. a.akbar@ucl.ac.uk.ORCID http://orcid.org/0000-0002-3763-9380
University College London · GBJackson Laboratory · USImperial College London · GBAgency for Science, Technology and Research · SGInstitute of Infection and Immunity · CAQueen Mary University of London · GBRoslin Institute · GBUniversidade Federal do Espírito Santo · BRUniversity of Connecticut · USUniversity of Michigan · USUniversity of Oxford · GBUniversity of Surrey · GB
Funding
MOLECULAR BIOLOGY COREP01AG021600 · NIA · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI HAYNES, LAURA · 2003 to 2016
$24.4MCombining Testosterone Therapy and Exercise to Improve Function Post Hip FractureR01AG051647 · NIA · WASHINGTON UNIVERSITY · PI BINDER, ELLEN F, FISHER, STEVEN R · 2017 to 2023
$15.9MTranslational Geroscience NetworkR33AG061456 · NIA · MAYO CLINIC ROCHESTER · PI JAMES L. KIRKLAND, STEPHEN B. KRITCHEVSKY · 2019 to 2026
$6.2MHigh-resolution single cell profiling of vaccine responsiveness in the elderlyR01AI142086 · NIAID · JACKSON LABORATORY · PI UCAR, DUYGU · 2019 to 2023
$2.9MGenomics and Epigenomics of the Elderly Response to Pneumococcal VaccinesR01AG052608 · NIA · JACKSON LABORATORY · PI BANCHEREAU, JACQUES F · 2016 to 2019
$2.5MThe molecular mechanisms of nutrient- and stress-dependent mTORC1 regulation mediated by human Sestrin2.R01DK111465 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CHO, UHN-SOO · 2016 to 2020
$2.4MIdentification and Interpretation of Chromatin Changes Associated with the Aging of Human Immune CellsR35GM124922 · NIGMS · JACKSON LABORATORY · PI UCAR, DUYGU · 2017 to 2021
$2.3MImmune Response to High-Dose vs. Standard Dose Influenza VaccineR01AG048023 · NIA · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI KUCHEL, GEORGE A, MCELHANEY, JANET E. · 2014 to 2018
$2.1MMechanisms underlying Hepatoprotective Roles of Sestrin2R01DK102850 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LEE, JUN HEE · 2015 to 2019
$1.7MMicrobiome Plasticity and Pathogenicity in Older Adults: Baselines and Transitions from Skilled Nursing CareR56AG060746 · NIA · JACKSON LABORATORY · PI KUCHEL, GEORGE A, OH, JULIA · 2019 to 2019
$779kRole of Senolytics in Lower Urinary Tract Aging and Voiding DisordersR21AG063528 · NIA · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI KUCHEL, GEORGE A, SMITH, PHILLIP PAUL · 2019 to 2020
$440kBiotechnology and Biological Sciences Research Council BB/L005336/1Cancer Research UK 26603Department of HealthMedical Research Council MR/P00184X/1Medical Research Council MR/T015853/1NIAID NIH HHS R01 AI142086NIA NIH HHS P01 AG021600NIA NIH HHS R01 AG048023NIA NIH HHS R01 AG051647NIA NIH HHS R01 AG052608NIA NIH HHS R21 AG063528NIA NIH HHS R33 AG061456NIA NIH HHS R56 AG060746NIDDK NIH HHS R01 DK102850NIDDK NIH HHS R01 DK111465NIGMS NIH HHS R35 GM124922Wellcome TrustWellcome Trust AZR00630
Abstract
Aging is associated with remodeling of the immune system to enable the maintenance of life-long immunity. In the CD8
Indexed as
Adaptor Proteins, Signal TransducingCD8-Positive T-LymphocytesCellular SenescenceCytotoxicity, ImmunologicGene Expression ProfilingHumansKiller Cells, NaturalMembrane ProteinsNK Cell Lectin-Like Receptor Subfamily KNuclear ProteinsReceptors, Antigen, T-CellReceptors, Natural Killer CellSestrinsSignal TransductionYellow FeverYellow fever virusAdaptor Proteins, Signal TransducingMembrane ProteinsNK Cell Lectin-Like Receptor Subfamily KNuclear ProteinsReceptors, Antigen, T-CellReceptors, Natural Killer CellSESN2 protein, humanSestrinsTYROBP protein, human
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.