ArticleNature immunology2020
Beta cell-specific CD8
Abstract read
In one paragraph
Article in Nature immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers.
0numbers the graph read from it
0cells of the map it votes in
81citing papers in PubMed
–field-weighted citation impact
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
81 citing papers in PubMed.
- Teplizumab induces persistent changes in the antigen-specific repertoire in individuals at risk for type 1 diabetes.The Journal of clinical investigation · 2024Trial
- Going to the source: pancreatic lymph nodes maintain stem-like CD8+ T cells in human type 1 diabetes.The Journal of clinical investigation · 2026Article
- Immune dysregulation and stem-like CD8+ T cell enrichment in type 1 diabetes pancreatic lymph nodes.The Journal of clinical investigation · 2026Article
- Structural Modulation and Binding of HLA-DQ8 by Cysteine-to-Serine Mutated Insulin Peptide: Insights from Molecular Dynamics Simulations.International journal of molecular sciences · 2026Article
- New and emerging therapies in type 1 diabetes mellitus.The Journal of clinical investigation · 2026Review
- CD8Nature reviews. Cardiology · 2026Review
- Aberrant immune regulation and enrichment of stem-like CD8bioRxiv : the preprint server for biology · 2026Article
- Immune cell profiling reveals expanded stem cell-like memory T cells in anti-GAD65-associated neurological syndromes.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Antigen-specific immunotherapy with a CD4Nature communications · 2026Article
- Reprogramming CAR T-Cells with designed bioPROTACs.bioRxiv : the preprint server for biology · 2026Article
- Anti-CD3 mAb treatment reshapes infiltrating T and β cells in the islets in autoimmune diabetes.JCI insight · 2026Article
- Developing a comprehensive database and search tool for single-cell ATAC-seq data.Scientific reports · 2026Article
- Regulation of T cell exhaustion and stemness: molecular mechanisms and implications for cancer immunotherapy.Cellular & molecular immunology · 2026Review
- Artificial intelligence-driven therapeutics for disease modification in type 1 diabetes: a digital public health and clinical translation framework.Frontiers in public health · 2026Review
- Epigenetic regulation of T cell exhaustion in cancer.Nature reviews. Cancer · 2026Review
- Imbalance of stem-like and effector T cell states in children with early type 1 diabetes across conventional and regulatory subsets.Nature communications · 2025Article
- T-cell receptor/CD28-targeted immunotherapeutics selectively drive naive T-cell expansion to generate functional HIV-specific responses.Journal of virology · 2025Article
- Article
- Early methionine availability attenuates T cell exhaustion.Nature immunology · 2025Article
- Oligodendrocyte-derived IL-33 regulates self-reactive CD8+ T cells in CNS autoimmunity.The Journal of experimental medicine · 2025Article
21 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
25 authors.
Hossam A Abdelsamed *Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Caitlin C Zebley *Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Hai Nguyen *Translational Research Program, Benaroya Research Institute, Seattle, WA, USA.
Rachel L RutishauserDepartment of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Yiping FanCenter for Applied Bioinformatics, St. Jude Children's Research Hospital, Memphis, TN, USA.
Hazem E GhoneimDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Jeremy Chase CrawfordDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID http://orcid.org/0000-0003-4096-6048
Francesca AlfeiDivision of Animal Physiology and Immunology, School of Life Sciences Weihenstephan, Technical University of Munich, Freising, Germany.
Shanta AlliDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Susan Pereira RibeiroDepartment of Pathology, Case Western Reserve University, Cleveland, OH, USA.
Ashley H CastellawDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Maureen A McGargillDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Hongjian JinCenter for Applied Bioinformatics, St. Jude Children's Research Hospital, Memphis, TN, USA.
Shannon K BoiDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Cate SpeakeDiabetes Research Program, Benaroya Research Institute, Seattle, WA, USA.
Elisavet SertiImmune Tolerance Network, Bethesda, MD, USA.
Laurence A TurkaImmune Tolerance Network, Bethesda, MD, USA.ORCID http://orcid.org/0000-0003-2104-6967
Michael E BuschVitalant Research Institute, San Francisco, CA, USA.
Mars StoneVitalant Research Institute, San Francisco, CA, USA.
Steven G DeeksDepartment of Medicine, University of California, San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-6371-747X
Rafick-Pierre SekalyDepartment of Pathology, Case Western Reserve University, Cleveland, OH, USA.
Dietmar ZehnDivision of Animal Physiology and Immunology, School of Life Sciences Weihenstephan, Technical University of Munich, Freising, Germany.ORCID http://orcid.org/0000-0003-1393-8527
Eddie A JamesTranslational Research Program, Benaroya Research Institute, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-7217-5729
Gerald T NepomTranslational Research Program, Benaroya Research Institute, Seattle, WA, USA.
Ben YoungbloodDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA. benjamin.youngblood@stjude.org.ORCID http://orcid.org/0000-0002-1261-9957
Funding
Immune Tolerance Network UM1 2023 SupplementUM1AI109565 · NIAID · BENAROYA RESEARCH INST AT VIRGINIA MASON · PI Mark S Anderson, Jane Hoyt Buckner · 2014 to 2026
$451.6MVirology CoreP30AI027763 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Monica Gandhi · 1988 to 2026
$93.6MPittsburgh Liver Research CenterP30DK120531 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DAVID A GELLER · 2019 to 2026
$10.9MEpigenetic Regulation of T-cell Exhaustion During Treated Chronic HIV InfectionR01AI114442 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI YOUNGBLOOD, BENJAMIN ALAN · 2015 to 2019
$2.1MDissecting the signals that maintain HIV-specific CD8+ T cell exhaustion - administrative supplementK23AI134327 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI RUTISHAUSER, RACHEL LENA · 2018 to 2022
$1.1MNCI NIH HHS L40 CA242818NIAID NIH HHS K23 AI134327NIAID NIH HHS P30 AI027763NIAID NIH HHS R01 AI114442NIAID NIH HHS UM1 AI109565NIDDK NIH HHS P30 DK120531
Abstract
The pool of beta cell-specific CD8
Indexed as
AdolescentAdultAnimalsAutoantigensCD8-Positive T-LymphocytesCell PlasticityCells, CulturedDiabetes Mellitus, Type 1DNA MethylationEpigenesis, GeneticFemaleFlow CytometryHumansImmunologic MemoryInsulin-Secreting CellsMaleAutoantigens
Identifiers
What OpenQuestion holds
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.