ArticleScientific reports2020
Role of rs454214 in Personality mediated Depression and Subjective Well-being.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Association between depression and subjective well-being among older adults in China: the mediating effect of self-assessed health.BMC public health · 2026Article
- Personality traits as mediators in the association betweenFrontiers in psychiatry · 2023Article
- Article
- College students' screening early warning factors in identification of suicide risk.Frontiers in genetics · 2022Article
- A study of negative life events driven depressive symptoms and academic engagement in Chinese college students.Scientific reports · 2021Article
- Impact ofFrontiers in genetics · 2021Article
- Omega-3 Eicosapentaenoic Acid Is Related to Happiness and a Sense of Fulfillment-A Study among Female Nursing Workers.Nutrients · 2020Article
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Authors and funding
26 authors.
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Abstract
Happiness and depression are interlinked and both heritable, while personality, as an important predictor of them, shares the genetic basis with them. We conjecture that genetic factors of depression can affect both depressive symptoms (DS) and subjective well-being (SWB), while personality traits play important roles in mediating this process. In this study, 878 Han Chinese college freshmen and 384 Han Chinese patients with the major depressive disorder (MDD) were included. SNPs were genotyped using AGENA MassARRAY iPLEX technology and we investigated an important MDD variant rs454214. Correlation, association and mediation analysis were employed, aiming to decipher the complex relationship between SWB, DS, personality traits and the genetic variant. Association study indicated that rs454214 was not only associated with both SWB and DS (P < 0.05), but also possibly linked to MDD. Mediational analysis showed that rs454214 had no direct effect on SWB and DS, but had a significant indirect effect through personality traits, i.e., Extraversion, Neuroticism, Agreeableness and Openness to Experience or SWB, Extraversion, Neuroticism and Agreeableness for DS. This study found a shared genetic basis for happiness and depression; the causal process could be better explained if personality traits are taken as mediating factors.
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