ArticleEye (London, England)2021
Factors affecting anatomical and visual outcome after macular hole surgery: findings from a large prospective UK cohort.
Article in Eye (London, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
76 citing papers in PubMed, 2 syntheses or guidelines pooled it, 141 citations in OpenAlex.
- Internal limiting membrane peel size and macular hole surgery outcome: a systematic review and individual participant data study of randomized controlled trials.Eye (London, England) · 2025Pooled it
- Surgical interventions for lamellar macular holes.The Cochrane database of systematic reviews · 2021Pooled it
- Influence of the dilution method on the intraocular duration of C3F8 in vitrectomy for macular hole: a randomized clinical trial.Arquivos brasileiros de oftalmologia · 2024Trial
- Comparison of safety and effectiveness between 23-gauge and 25-gauge vitrectomy surgery in common vitreoretinal diseases.PloS one · 2021Trial
- Anatomical and functional outcomes and prognostic factors after idiopathic full-thickness macular hole surgery: a single-center retrospective cohort study.BMC ophthalmology · 2026Article
- Flower petal no-hole-touch ILM peeling with air tamponade for large chronic macular holes: outcomes from a resource-limited setting.Eye (London, England) · 2026Article
- Application of subretinal injection of balanced salt solution for the management of large-diameter macular holes.BMC ophthalmology · 2026Article
- Short-term visual acuity responder rates after full-thickness macular hole surgery stratified by hole size: a retrospective cohort study.BMC ophthalmology · 2026Article
- Timing of macular hole surgery among vitreoretinal surgeons in the UK: A national survey, review of literature and future direction.Eye (London, England) · 2026Review
- Assessment of internal limiting membrane flap and autologous whole blood techniques in complicated macular hole surgery.BMC ophthalmology · 2026Article
- A novel index using optical coherence tomography for predicting anatomical and visual outcomes of idiopathic macular hole surgery.International journal of retina and vitreous · 2026Article
- Temporal Arcuate Relaxing Retinotomy for Persistent Full-Thickness Macular Holes: Anatomical and Functional Assessment.Journal of clinical medicine · 2026Article
- Visual and anatomical outcomes of full-thickness macular hole surgery and associated factors in selected hospitals in Tanzania.PloS one · 2026Article
- Simple Superior Inverted Flap Technique with Extended Internal Limiting Membrane Peeling for the Treatment of Large Macular Holes.Clinical ophthalmology (Auckland, N.Z.) · 2026Article
- Novel dual-layer internal limiting membrane flap with superior-inferior coverage combined with autologous blood application for large macular hole: anatomical and functional outcomes.Frontiers in medicine · 2026Article
- Article
- Gas versus GaslEss surgery for full thickness Macular hole (GEM): study protocol for a randomised, assessor-masked, surgical feasibility study.BMJ open ophthalmology · 2025Article
- Evaluation of the upper internal limiting membrane flap technique for surgical closure of medium and large macular holes.BMC ophthalmology · 2025Article
- Predictive Value of Preoperative Anatomical and Functional Parameters for Long-Term Visual Outcomes After Full-Thickness Macular Hole Surgery with the Inverted Flap Technique.Journal of clinical medicine · 2025Article
- Dynamic Structural Recovery Parameters Enhance Prediction of Visual Outcomes After Macular Hole Surgery.Translational vision science & technology · 2025Article
16 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo reassess the definition of a large macular hole, factors predicting hole closure and post-surgery visual recovery.
designDatabase study of 1483 primary macular hole operations. Eligible operations were primary MH operations treated with a vitrectomy and a gas or air tamponade. Excluded were eyes with a history of retinal detachment, high myopia, previous vitrectomy or trauma.
resultsA higher proportion of operations were performed in eyes from females (71.1%) who were 'on average' younger (p < 0.001), with slightly larger holes (p < 0.001) than male patients. Sulfur hexafluoride gas was generally used for smaller holes (p < 0.001). From 1253 operations with a known surgical outcome, successful hole closure was achieved in 1199 (96%) and influenced by smaller holes and complete ILM peeling (p < 0.001), but not post-surgery positioning (p = 0.072). A minimum linear diameter of ~500 μm marked the threshold where the success rate started to decline. From the 1056 successfully closed operations eligible for visual outcome analysis, visual success (defined as visual acuity of 0.30 or better logMAR) was achieved in 488 (46.2%) eyes. At the multivariate level, the factors predicting visual success were better pre-operative VA, smaller hole size, shorter duration of symptoms and the absence of AMD.
conclusionsFemales undergoing primary macular hole surgery tend to be younger and have larger holes than male patients. The definition of a large hole should be changed to around 500 μm, and patients should be operated on early to help achieve a good post-operative VA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.