SynthesisNature communications2020
The genetic architecture of membranous nephropathy and its potential to improve non-invasive diagnosis.
Open access · goldAbstract readMeta-Analysis
In one paragraph
Synthesis in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 125 papers, 6 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
125citing papers in PubMed, 6 pooled it
17.2field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
125 citing papers in PubMed, 6 syntheses or guidelines pooled it, 213 citations in OpenAlex.
- Efficacy and safety of obinutuzumab in refractory membranous nephropathy: a single-arm meta-analysis.Frontiers in immunology · 2026Pooled it
- Causality between diabetes and membranous nephropathy: Mendelian randomization.Clinical and experimental nephrology · 2025Pooled it
- Genetics in chronic kidney disease: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference.Kidney international · 2022Guideline
- Specific alterations of gut microbiota in patients with membranous nephropathy: A systematic review and meta-analysis.Frontiers in physiology · 2022Pooled it
- Recent Advances in Clinical Diagnosis and Pharmacotherapy Options of Membranous Nephropathy.Frontiers in pharmacology · 2022Pooled it
- Eleven genomic loci affect plasma levels of chronic inflammation marker soluble urokinase-type plasminogen activator receptor.Communications biology · 2021Pooled it
- Scoping Review of Polygenic Risk Scores in Kidney-Related Traits.Kidney international reports · 2026Article
- Atlas of glomerular disease-specific genetic effects on blood transcriptome.medRxiv : the preprint server for health sciences · 2026Article
- Multi-Modal, Machine Learning-Driven Framework Integrating Multi-Omics for Personalized Chronic Kidney Disease Management.Journal of clinical medicine · 2026Review
- A Cross-Tissue Transcriptome-Wide Association Study Identifies Novel Susceptibility Genes for Glomerular Diseases.Biomedicines · 2026Article
- Causal relationship between autoimmune diseases and iron deficiency anemia: a two-sample mendelian randomization study.Scientific reports · 2026Article
- Membranous Nephropathy: Antigenic Landscape and a Novel Pathogenetic Model.International journal of molecular sciences · 2026Review
- A Common Missense Variant, W335S, in β2-Glycoprotein I (APOH) is Associated with Increased Autoantibody Levels but Reduced Venous Thromboembolism Risk.medRxiv : the preprint server for health sciences · 2026Article
- Complement-Mediated Kidney Diseases: Role of Alternative Pathway in Glomerular Inflammation.Kidney international reports · 2026Review
- A New Perspective on Predicting PLA2R-Associated Membranous Nephropathy Relapse: The Value of a Genetic Risk Score.Journal of inflammation research · 2026Article
- A Phenome-Wide Association and Mendelian Randomization Study of Genetically Predicted Membranous Nephropathy with Multiple Diseases.Kidney & blood pressure research · 2026Article
- Povetacicept for IgA Nephropathy and Primary Membranous Nephropathy.Kidney international reports · 2026Article
- Contemporary review of primary membranous nephropathy.Frontiers in immunology · 2026Review
- Spontaneous Remission of Late Relapsing Membranous Nephropathy After Previous Immunosuppressant-Induced Remission: Case Report.Case reports in nephrology · 2026Article
- Antibody-induced internalization and degradation of PLA2R amplifies CD4Theranostics · 2026Article
65 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on byGenetics of MN.2020
Authors and funding
120 authors at 20 institutions in 16 countries.
Jingyuan Xie *Department of Nephrology, Institute of Nephrology, Shanghai Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. nephroxie@163.com.
Lili Liu *Department of Medicine, Division of Nephrology, Columbia University, College of Physicians & Surgeons, New York, USA.ORCID http://orcid.org/0000-0002-2622-9669
Nikol Mladkova *Department of Medicine, Division of Nephrology, Columbia University, College of Physicians & Surgeons, New York, USA.
Yifu LiDepartment of Medicine, Division of Nephrology, Columbia University, College of Physicians & Surgeons, New York, USA.
Hong RenDepartment of Nephrology, Institute of Nephrology, Shanghai Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Weiming WangDepartment of Nephrology, Institute of Nephrology, Shanghai Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Zhao CuiRenal Division, Department of Medicine, Peking University First Hospital, Beijing, China.
Li LinDepartment of Nephrology, Institute of Nephrology, Shanghai Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Xiaofan HuDepartment of Nephrology, Institute of Nephrology, Shanghai Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Xialian YuDepartment of Nephrology, Institute of Nephrology, Shanghai Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Jing XuDepartment of Nephrology, Institute of Nephrology, Shanghai Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Gang LiuRenal Division, Department of Medicine, Peking University First Hospital, Beijing, China.
Yasar CaliskanDivision of Nephrology, Department of Internal Medicine, Istanbul School of Medicine, Istanbul University, Istanbul, Turkey.
Carlo SidoreIstituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Monserrato, Cagliari, Italy.
Olivia BalderesDepartment of Medicine, Division of Nephrology, Columbia University, College of Physicians & Surgeons, New York, USA.
Raphael J RosenDepartment of Medicine, Division of Nephrology, Columbia University, College of Physicians & Surgeons, New York, USA.
Monica BodriaDepartment of Medicine, Division of Nephrology, Columbia University, College of Physicians & Surgeons, New York, USA.
Francesca ZanoniDepartment of Medicine, Division of Nephrology, Columbia University, College of Physicians & Surgeons, New York, USA.
Jun Y ZhangDepartment of Medicine, Division of Nephrology, Columbia University, College of Physicians & Surgeons, New York, USA.ORCID http://orcid.org/0000-0003-4996-8699
Priya KrithivasanDepartment of Medicine, Division of Nephrology, Columbia University, College of Physicians & Surgeons, New York, USA.
Karla MehlDepartment of Medicine, Division of Nephrology, Columbia University, College of Physicians & Surgeons, New York, USA.
Maddalena MarasaDepartment of Medicine, Division of Nephrology, Columbia University, College of Physicians & Surgeons, New York, USA.ORCID http://orcid.org/0000-0003-0712-2329
Atlas KhanDepartment of Medicine, Division of Nephrology, Columbia University, College of Physicians & Surgeons, New York, USA.
Fatih OzayDepartment of Medicine, Division of Nephrology, Columbia University, College of Physicians & Surgeons, New York, USA.ORCID http://orcid.org/0000-0002-1383-7892
Pietro A CanettaDepartment of Medicine, Division of Nephrology, Columbia University, College of Physicians & Surgeons, New York, USA.ORCID http://orcid.org/0000-0003-1130-5486
Andrew S BombackDepartment of Medicine, Division of Nephrology, Columbia University, College of Physicians & Surgeons, New York, USA.ORCID http://orcid.org/0000-0001-5449-1667
Gerald B AppelDepartment of Medicine, Division of Nephrology, Columbia University, College of Physicians & Surgeons, New York, USA.
Simone Sanna-CherchiDepartment of Medicine, Division of Nephrology, Columbia University, College of Physicians & Surgeons, New York, USA.ORCID http://orcid.org/0000-0002-6185-948X
Matthew G SampsonDepartment of Pediatrics-Nephrology, University of Michigan School of Medicine, Ann Arbor, MI, USA.
Laura H MarianiDivision of Nephrology, Department of Medicine, University of Michigan, Ann Arbor, MI, USA.
Agnieszka Perkowska-PtasinskaDepartment of Transplantology, Nephrology and Internal Diseases, Medical University of Warsaw, Warsaw, Poland.
Magdalena DurlikDepartment of Transplantology, Nephrology and Internal Diseases, Medical University of Warsaw, Warsaw, Poland.
Krzysztof MuchaDepartment of Immunology, Transplantology and Internal Diseases, Medical University of Warsaw, Warsaw, Poland.ORCID http://orcid.org/0000-0002-6613-7638
Barbara MoszczukDepartment of Immunology, Transplantology and Internal Diseases, Medical University of Warsaw, Warsaw, Poland.
Bartosz ForoncewiczDepartment of Immunology, Transplantology and Internal Diseases, Medical University of Warsaw, Warsaw, Poland.
Leszek PączekDepartment of Immunology, Transplantology and Internal Diseases, Medical University of Warsaw, Warsaw, Poland.
Ireneusz HaburaDepartment of Nephrology, University Hospital of Karol Marcinkowski in Zielona Góra, Zielona Góra, Poland.
Elisabet ArsMolecular Biology Laboratory and Nephrology Department, Fundació Puigvert, Instituto de Investigaciones Biomédicas Sant Pau, Universitat Autònoma de Barcelona, REDINREN, IISCIII, Barcelona, Spain.
Jose BallarinMolecular Biology Laboratory and Nephrology Department, Fundació Puigvert, Instituto de Investigaciones Biomédicas Sant Pau, Universitat Autònoma de Barcelona, REDINREN, IISCIII, Barcelona, Spain.
Laila-Yasmin ManiDepartment of Nephrology and Hypertension, Bern University Hospital, University of Bern, Bern, Switzerland.
Bruno VogtDepartment of Nephrology and Hypertension, Bern University Hospital, University of Bern, Bern, Switzerland.ORCID http://orcid.org/0000-0002-1548-6387
Savas OzturkNephrology Clinic, Haseki Training and Research Hospital, Istanbul, Turkey.
Abdülmecit YildizDepartment of Nephrology, Uludag University Faculty of Medicine, Bursa, Turkey.
Nurhan SeyahiDivision of Nephrology, Department of Internal Medicine, Cerrahpasa Medical Faculty, Istanbul University - Cerrahpasa, Istanbul, Turkey.ORCID http://orcid.org/0000-0001-7427-618X
Hakki ArikanDivision of Nephrology, Department of Internal Medicine, Marmara University School of Medicine, Istanbul, Turkey.
Mehmet KocDivision of Nephrology, Department of Internal Medicine, Marmara University School of Medicine, Istanbul, Turkey.ORCID http://orcid.org/0000-0002-1433-8403
Taner BasturkDepartment of Nephrology, Sisli Hamidiye Etfal Training and Research Hospital, Istanbul, Turkey.
Gonca KarahanDepartment of Medical Biology, Istanbul School of Medicine, Istanbul University, Istanbul, Turkey.
Sebahat Usta AkgulDepartment of Medical Biology, Istanbul School of Medicine, Istanbul University, Istanbul, Turkey.ORCID http://orcid.org/0000-0003-0176-3344
Mehmet Sukru SeverDivision of Nephrology, Department of Internal Medicine, Istanbul School of Medicine, Istanbul University, Istanbul, Turkey.
Dan ZhangDepartment of Nephrology, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Domenico SantoroDepartment of Cinical and Experimental Medicine, Unit of Nephrology, University of Messina, Messina, Italy.ORCID http://orcid.org/0000-0002-4279-6559
Mario BonominiDepartment of Medicine, University of Chieti-Pescara, SS. Annunziata Hospital, Chieti, Italy.
Francesco LondrinoS. Andrea Hospital, La Spezia, Italy.
Loreto GesualdoUniversity of Bari, Bari, Italy.
Jana ReiterovaDepartment of Nephrology, 1st Faculty of Medicine and General University Hospital, Charles University, Prague, Czech Republic.
Vladimir TesarDepartment of Nephrology, 1st Faculty of Medicine and General University Hospital, Charles University, Prague, Czech Republic.ORCID http://orcid.org/0000-0001-6982-0689
Claudia IzziSecond Division of Nephrology, ASST-Spedali Civili di Brescia Presidio di Montichiari, Brescia, Italy.
Silvana SavoldiUnit of Nephrology and Dialysis ASL TO4, Cirié, Turin, Italy.
Donatella SpottiSan Raffaele Hospital, Milan, Italy.
Carmelita MarcantoniCannizzaro Hospital, Catania, Italy.
Piergiorgio MessaNephrology Dialysis and Kidney Transplant Unit, Fundazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Università degli studi di Milano, Milan, Italy.
Marco GallianiSandro Pertini Hospital, Rome, Italy.
Dario RoccatelloSan Giovanni Bosco Hospital (ERK-net Member) and University of Turin, Turin, Italy.
Simona GranataRenal Unit, Department of Medicine, University of Verona, Verona, Italy.
Gianluigi ZazaRenal Unit, Department of Medicine, University of Verona, Verona, Italy.ORCID http://orcid.org/0000-0002-6004-6196
Francesca LuganiDivision of Nephrology, Dialysis, Transplantation, IRCCS Giannina Gaslini, Genoa, Italy.
GianMarco GhiggeriDivision of Nephrology, Dialysis, Transplantation, IRCCS Giannina Gaslini, Genoa, Italy.
Isabella PisaniDepartment of Medicine and Surgery, University of Parma, Parma, Italy.
Landino AllegriDepartment of Medicine and Surgery, University of Parma, Parma, Italy.
Ben SprangersDepartment of Microbiology and Immunology, Laboratory of Molecular Immunology, Rega Institute, KU, Leuven, Belgium.
Jin-Ho ParkDepartment of Family Medicine, Seoul National University College of Medicine and Seoul National University Hospital, Seoul, Korea.ORCID http://orcid.org/0000-0002-3942-6813
BeLong ChoDepartment of Family Medicine, Seoul National University College of Medicine and Seoul National University Hospital, Seoul, Korea.
Yon Su KimBiomedical Sciences, Seoul National University College of Medicine, Seoul, Korea.
Dong Ki KimKidney Research Institute, Seoul National University College of Medicine, Seoul, Korea.
Hitoshi SuzukiDepartment of Nephrology, Juntendo University Faculty of Medicine, Tokyo, Japan.ORCID http://orcid.org/0000-0002-1901-2111
Antonio AmorosoDepartment of Medical Sciences, University of Torino and Immunogenetics and Transplant Biology Service, University Hospital "Città della Salute e della Scienza di Torino", Turin, Italy.ORCID http://orcid.org/0000-0002-9437-9407
Daniel C CattranDepartment of Nephrology, University of Toronto, Toronto General Hospital, Toronto, ON, Canada.
Fernando C FervenzaDivision of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, USA.
Antonello PaniDepartment of Nephrology and Dialysis, G. Brotzu Hospital, Cagliari, Italy.
Patrick HamiltonManchester Institute of Nephrology and Transplantation, Manchester University Hospitals NHS Trust, Manchester, UK.
Shelly HarrisManchester Institute of Nephrology and Transplantation, Manchester University Hospitals NHS Trust, Manchester, UK.
Sanjana GuptaDepartment of Nephrology, Division of Medicine, University College London, London, UK.
Chris CheshireDepartment of Nephrology, Division of Medicine, University College London, London, UK.
Stephanie DufekDepartment of Nephrology, Division of Medicine, University College London, London, UK.ORCID http://orcid.org/0000-0002-6323-6673
Naomi IsslerDepartment of Nephrology, Division of Medicine, University College London, London, UK.
Ruth J PepperDepartment of Nephrology, Division of Medicine, University College London, London, UK.
John ConnollyDepartment of Nephrology, Division of Medicine, University College London, London, UK.
Stephen PowisDepartment of Nephrology, Division of Medicine, University College London, London, UK.
Detlef BockenhauerDepartment of Nephrology, Division of Medicine, University College London, London, UK.
Horia C StanescuDepartment of Nephrology, Division of Medicine, University College London, London, UK.
Neil AshmanRenal Unit, Royal London Hospital, Barts Health, Whitechapel, London, UK.
Ruth J F LoosThe Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0002-8532-5087
Eimear E KennyThe Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Matthias WuttkeInstitute of Genetic Epidemiology, Dep. of Biometry, Epidemiology, and Medical Bioinformatics, Faculty of Medicine and Medical Center - University of Freiburg, Freiburg, Germany.ORCID http://orcid.org/0000-0003-3420-5082
Kai-Uwe EckardtDepartment of Nephrology and Medical Intensive Care, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Anna KöttgenInstitute of Genetic Epidemiology, Dep. of Biometry, Epidemiology, and Medical Bioinformatics, Faculty of Medicine and Medical Center - University of Freiburg, Freiburg, Germany.ORCID http://orcid.org/0000-0002-4671-3714
Julia M HofstraDepartment of Nephrology, Radboud University Medical Center, Nijmegen, The Netherlands.
Marieke J H CoenenDepartment of Human Genetics, Radboud University Medical Centre, Radboud Institute for Health Sciences, Nijmegen, The Netherlands.
Lambertus A KiemeneyDepartment of Epidemiology, Biostatistics & HTA, Radboud University Medical Center, Nijmegen, The Netherlands.
Shreeram AkileshDepartment of Anatomic Pathology, University of Washington, Seattle, USA.ORCID http://orcid.org/0000-0003-3152-7991
Matthias KretzlerDivision of Nephrology, Department of Medicine, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0003-4064-0582
Lawrence H BeckDepartment of Medicine, Renal Section, Boston University School of Medicine and Boston Medical Center, Boston, MA, USA.
Benedicte StengelInstitut National de la Santé et de la Recherche Médicale, Centre for Research in Epidemiology and Population Health, Villejuif, France.
Hanna DebiecSorbonne Université, Pierre and Marie Curie University Paris 06, Paris, France.
Pierre RoncoSorbonne Université, Pierre and Marie Curie University Paris 06, Paris, France.ORCID http://orcid.org/0000-0002-0280-6900
Jack F M WetzelsDepartment of Nephrology, Radboud University Medical Center, Nijmegen, The Netherlands.ORCID http://orcid.org/0000-0002-0650-6921
Magdalena ZoledziewskaIstituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Monserrato, Cagliari, Italy.
Francesco CuccaIstituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Monserrato, Cagliari, Italy.ORCID http://orcid.org/0000-0002-7414-1995
Iuliana Ionita-LazaDepartment of Biostatistics, Mailman School of Public Health, Columbia University, New York, NY, USA.
Hajeong LeeKidney Research Institute, Seoul National University College of Medicine, Seoul, Korea.
Elion HoxhaIII Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Rolf A K StahlIII Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Paul BrenchleyFaculty of Biology, Medicine, Health, University of Manchester, Manchester, UK.
Francesco ScolariSecond Division of Nephrology, ASST-Spedali Civili di Brescia Presidio di Montichiari, Brescia, Italy.
Ming-Hui ZhaoRenal Division, Department of Medicine, Peking University First Hospital, Beijing, China.ORCID http://orcid.org/0000-0003-3340-3108
Ali G GharaviDepartment of Medicine, Division of Nephrology, Columbia University, College of Physicians & Surgeons, New York, USA.ORCID http://orcid.org/0000-0003-2801-233X
Robert Kleta *Department of Nephrology, Division of Medicine, University College London, London, UK. r.kleta@ucl.ac.uk.ORCID http://orcid.org/0000-0002-0228-8656
Nan Chen *Department of Nephrology, Institute of Nephrology, Shanghai Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Krzysztof Kiryluk *Department of Medicine, Division of Nephrology, Columbia University, College of Physicians & Surgeons, New York, USA. kk473@columbia.edu.ORCID http://orcid.org/0000-0002-5047-6715
Columbia University · USShanghai Jiao Tong University · CNUniversity College London · GBMedical University of Warsaw · PLIstanbul University · TRRadboud University Nijmegen · NLSeoul National University · KRInstitute of Genetic and Biomedical Research · ITMinistry of Education of the People's Republic of China · CNUniversity of Parma · ITAzienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia · ITCharles University · CZFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico · ITIstituto Giannina Gaslini · ITManchester University NHS Foundation Trust · GBMarmara University · TRSorbonne Université · FRUniversitat Autònoma de Barcelona · ESUniversität Hamburg · DEUniversity of Bern · CH
Funding
Central Hub for Kidney Precision MedicineU24DK114886 · NIDDK · UNIVERSITY OF WASHINGTON · PI Jonathan Himmelfarb, Matthias Kretzler · 2022 to 2026
$21.1MTraining Program in Clinical & Translationa Research in Human Glomerular DiseaseU54DK083912 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HOLZMAN, LAWRENCE B. · 2009 to 2023
$20.3MGenomics of glomerular diseaseRC2DK116690 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI KIRYLUK, KRZYSZTOF, KRETZLER, MATTHIAS · 2018 to 2022
$5.0MGenetics of IgA nephropathy by integrative network-based association studiesR01DK105124 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Krzysztof Kiryluk · 2015 to 2026
$4.8MWhole Genome Sequencing for Nephrotic Syndrome DiscoveryR01DK119380 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI Dongwon Lee, MATTHEW Gordon SAMPSON · 2019 to 2026
$3.7MAPOL1 - associated nephropathy from human-derived, intrarenal perspectiveR01DK108805 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MATTHEW Gordon SAMPSON, Simone Sanna-Cherchi · 2016 to 2026
$3.4MSafety and Efficacy of Human Clinical Trials Using Kidney-on-a-Chip Microphysiological SystemsUH3TR003288 · NCATS · UNIVERSITY OF WASHINGTON · PI FREEDMAN, BENJAMIN SOLOMON, HIMMELFARB, JONATHAN · 2022 to 2024
$2.3MAncestry, Genetic Risk and Health Disparities in Immune-Mediated NephritisR01MD009223 · NIMHD · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BOMBACK, ANDREW STEPHEN, GHARAVI, ALI G · 2014 to 2018
$2.2MBig Omics Data Engine 2 SupercomputerS10OD026880 · OD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KOVATCH, PATRICIA · 2019 to 2019
$2.0MTransforming Genomics with 5 PB Big Omics Data Engine Cray CS300-AC SupercomputerS10OD018522 · OD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KOVATCH, PATRICIA · 2014 to 2014
$1.9MRedefining membranous nephropathy by autoantibody-specific subclassificationR01DK097053 · NIDDK · BOSTON MEDICAL CENTER · PI BECK, LAURENCE H · 2013 to 2017
$1.7MTraining Medical Students in NIDDK ResearchT35DK093430 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI QAIS AL-AWQATI, Utpal Pajvani · 2012 to 2026
$1.3MMedical Research Council MR/J010847/1NCATS NIH HHS UH3 TR003288NIDDK NIH HHS R01 DK097053NIDDK NIH HHS R01 DK105124NIDDK NIH HHS R01 DK108805NIDDK NIH HHS R01 DK119380NIDDK NIH HHS RC2 DK116690NIDDK NIH HHS U24 DK114886NIDDK NIH HHS U54 DK083912NIDDK NIH HHS UH3 DK114908NIH HHS S10 OD018522NIH HHS S10 OD026880NIMHD NIH HHS R01 MD009223
Abstract
Membranous Nephropathy (MN) is a rare autoimmune cause of kidney failure. Here we report a genome-wide association study (GWAS) for primary MN in 3,782 cases and 9,038 controls of East Asian and European ancestries. We discover two previously unreported loci, NFKB1 (rs230540, OR = 1.25, P = 3.4 × 10
Indexed as
Genome-Wide Association StudyAllelesAmino Acid SequenceAsian PeopleCase-Control StudiesGlomerulonephritis, MembranousHumansInterferon Regulatory Factor-4Interferon Regulatory FactorsModels, MolecularNF-kappa B p50 SubunitPolymorphism, Single NucleotideReceptors, Phospholipase A2White PeopleInterferon Regulatory Factor-4Interferon Regulatory FactorsNF-kappa B p50 SubunitNFKB1 protein, humanPLA2R1 protein, humanReceptors, Phospholipase A2
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