ArticleJournal of clinical medicine2020
Salivary Biomarkers and Their Correlation with Pain and Stress in Patients with Burning Mouth Syndrome.
Article in Journal of clinical medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 40 citations in OpenAlex.
- Associations between traditional Chinese medicine syndrome types, emotion and immune function in patients with burning mouth syndrome.Odontology · 2026Article
- Associations between traditional Chinese medicine syndrome types, emotion and immune function in patients with burning mouth syndrome.Odontology · 2026Article
- Effects ofIntegrative medicine research · 2026Review
- Review
- Efficacy of N-Acetyl Cysteine in the Treatment of Burning Mouth Syndrome-A Randomized Controlled Trial.Dentistry journal · 2025Article
- Burning Mouth Syndrome Underlying Factors: A Roadmap From a Network Perspective.Oral diseases · 2025Article
- A pilot study of the relationship between salivary microbial characteristics and endocrine and immune function in patients with burning mouth syndrome.Clinical oral investigations · 2024Article
- Salivary Immunoglobulin a Alterations in Health and Disease: A Bibliometric Analysis of Diagnostic Trends from 2009 to 2024.Antibodies (Basel, Switzerland) · 2024Article
- Article
- Burning Mouth Syndrome Treated with Low-Level Laser and Clonazepam: A Randomized, Single-Blind Clinical Trial.Biomedicines · 2024Article
- Bibliometric Analysis and Visualization of Clinical Trials on Psychological Stress and Oral Health (1967-2024).Cureus · 2024Review
- Comprehensive analysis of the oral microbiota and metabolome change in patients of burning mouth syndrome with psychiatric symptoms.Journal of oral microbiology · 2024Article
- Salivary Complaints in Burning Mouth Syndrome: A Cross Sectional Study on 500 Patients.Journal of clinical medicine · 2023Article
- Effect of thermal and chemical treatments used for SARS-COV-2 inactivation in the measurement of saliva analytes.Scientific reports · 2022Article
- Response to Treatment with Melatonin and Clonazepam versus Placebo in Patients with Burning Mouth Syndrome.Journal of clinical medicine · 2022Article
- Impact of the COVID-19 pandemic upon patients with burning mouth syndrome.Journal of stomatology, oral and maxillofacial surgery · 2022Article
- The Role of Salivary C-Reactive Protein in Systemic and Oral Disorders: A Systematic Review.Medical journal of the Islamic Republic of Iran · 2022Review
- Role of Photobiomodulation Therapy in Neurological Primary Burning Mouth Syndrome. A Systematic Review and Meta-Analysis of Human Randomised Controlled Clinical Trials.Pharmaceutics · 2021Review
- Proteomics-Based Identification of Salivary Changes in Patients with Burning Mouth Syndrome.Biology · 2021Article
- How Well Do Current Laboratory Biomarkers Inform Clinical Decision-Making in Chronic Pain Management?Journal of pain research · 2021Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate a panel of salivary analytes involving biomarkers of inflammation, stress, immune system and antioxidant status in patients with burning mouth syndrome (BMS) and to study their relationship with clinical variables. MATERIALS AND
methodsA total of 51 patients with BMS and 31 controls were consecutively enrolled in the study, with the recording of oral habits, the severity of pain using a visual analogue scale (VAS), the Hospital Anxiety and Depression (HAD) score and the Oral Health Impact Profile-14 (OHIP14) score. Resting whole saliva was collected with the drainage technique, followed by the measurement of 11 biomarkers.
resultsThe salivary flow was higher in patients with BMS. Among all the biomarkers studied, significantly higher levels of alpha-amylase, immunoglobulin A (IgA), and macrophage inflammatory protein-4 (MIP4) and lower levels of uric acid and ferric reducing activity of plasma (FRAP) were observed in the saliva of patients with BMS and the controls (
conclusionsBMS is associated with changes in salivary biomarkers of inflammation, oxidative stress and stress, being related to the degree of pain and anxiety.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.