ArticleNanomaterials (Basel, Switzerland)2020
Nanocellulose-Based Patches Loaded with Hyaluronic Acid and Diclofenac towards Aphthous Stomatitis Treatment.
Article in Nanomaterials (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 37 citations in OpenAlex.
- Solid Microneedles from Poly(3-hydroxybutyrate-co-3-hydroxyvalerate-co-3-hydroxyhexanoate): A Solvent-Free, Biodegradable Platform for Drug Delivery.Pharmaceutics · 2026Article
- Nanocellulose, the Green Biopolymer Trending in Pharmaceuticals: A Patent Review.Pharmaceutics · 2024Review
- Review
- Nanocellulose Sponges Containing Antibacterial Basil Extract.International journal of molecular sciences · 2023Article
- Review
- Bioactive Bacterial Nanocellulose Membranes Enriched withMaterials (Basel, Switzerland) · 2022Article
- Cellulose and protein nanofibrils: Singular biobased nanostructures for the design of sustainable advanced materials.Frontiers in bioengineering and biotechnology · 2022Review
- Natural Polymers-Based Materials: A Contribution to a Greener Future.Molecules (Basel, Switzerland) · 2021Review
- Spherical Cellulose Micro and Nanoparticles: A Review of Recent Developments and Applications.Nanomaterials (Basel, Switzerland) · 2021Review
- Bacterial Nanocellulose toward Green Cosmetics: Recent Progresses and Challenges.International journal of molecular sciences · 2021Review
- Bacterial Nanocellulose in Dentistry: Perspectives and Challenges.Molecules (Basel, Switzerland) · 2020Review
- Antibacterial Multi-Layered Nanocellulose-Based Patches Loaded with Dexpanthenol for Wound Healing Applications.Nanomaterials (Basel, Switzerland) · 2020Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Nanostructured patches composed of bacterial nanocellulose (BNC), hyaluronic acid (HA) and diclofenac (DCF) were developed, envisioning the treatment of aphthous stomatitis. Freestanding patches were prepared via diffusion of aqueous solutions of HA and DCF, with different concentrations of DCF, into the wet BNC three-dimensional porous network. The resultant dual polysaccharides-based patches with a nanostructured morphology present thermal stability up to 200 °C, as well as good dynamic mechanical properties, with a storage modulus higher than 1.0 GPa. In addition, the patches are non-cytotoxic to human keratinocytes (HaCaT cells), with a cell viability of almost 100% after 24 h. The in vitro release profile of DCF from the patches was evaluated in simulated saliva, and the data refer to a diffusion- and swelling-controlled drug-release mechanism. The attained results hint at the possibility of using these dual polysaccharides-based oral mucosal patches to target aphthous stomatitis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.