Evidence map›Paper›PMID 32231050›Full record

ArticleNutrients2020

Celiac Disease, Gluten-Free Diet, and Metabolic and Liver Disorders.

Marco Valvano, Salvatore Longo, Gianpiero Stefanelli, Giuseppe Frieri, Angelo Viscido, Giovanni Latella

Open access · goldAbstract read
In one paragraph

Article in Nutrients, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 2 pooled it
5.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 54 citations in OpenAlex.

  1. Pooled it
  2. Guideline
  3. Trial
  4. Trial
  5. Article
  6. Article
  7. Article
  8. Review
  9. Gluten's silent strike: Unmasking its impact on liver health.World journal of gastrointestinal pathophysiology · 2025
    Review
  10. Evaluation of Pancreatic Steatosis in Patients with Celiac Disease.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2025
    Article
  11. Review
  12. Review
  13. Review
  14. Article
  15. Review
  16. Article
  17. Article
  18. Review
  19. Article
  20. Fatty liver and celiac disease: Why worry?World journal of hepatology · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Marco ValvanoGastroenterology, Hepatology and Nutrition division, Department of Life, Health and Environmental Sciences, University of L'Aquila, 67100 L'Aquila, Italy.ORCID 0000-0002-2201-6279
Salvatore LongoGastroenterology, Hepatology and Nutrition division, Department of Life, Health and Environmental Sciences, University of L'Aquila, 67100 L'Aquila, Italy.ORCID 0000-0002-1888-7290
Gianpiero StefanelliGastroenterology, Hepatology and Nutrition division, Department of Life, Health and Environmental Sciences, University of L'Aquila, 67100 L'Aquila, Italy.
Giuseppe FrieriGastroenterology, Hepatology and Nutrition division, Department of Life, Health and Environmental Sciences, University of L'Aquila, 67100 L'Aquila, Italy.
Angelo ViscidoGastroenterology, Hepatology and Nutrition division, Department of Life, Health and Environmental Sciences, University of L'Aquila, 67100 L'Aquila, Italy.ORCID 0000-0001-8513-3758
Giovanni LatellaGastroenterology, Hepatology and Nutrition division, Department of Life, Health and Environmental Sciences, University of L'Aquila, 67100 L'Aquila, Italy.ORCID 0000-0001-6341-5711
University of L'Aquila · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Celiac disease (CD) is a chronic autoimmune enteropathy triggered by the ingestion of gluten in genetically predisposed individuals. At the time of diagnosis, the frequency of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis in individuals with CD appears to be similar to that of the general population, although a lower body mass index and a lower rate of hypercholesterolemia and type 2 diabetes mellitus are observed at diagnosis in CD patients. The effect of a gluten-free diet (GFD) in individuals with these liver and metabolic disorders is still a matter of debate. The aim of this study was to investigate the links between a GFD and metabolic/liver disorders in CD patients. A systematic electronic search of the literature from January 2009 to December 2019 was performed using Medline, Web of Science, Scopus, and the Cochrane Library. Only papers written in English concerning metabolic and liver disorders in adult patients with CD were included. Out of 1195 citations, 14 eligible studies were identified. Increases in the frequency of NAFLD, weight gain, and alterations of the lipid profile suggest that important changes happen in celiac patients on a GFD, though the physiopathology of these conditions is unclear. Although a GFD is the only effective treatment available for CD, liver function, body weight, and metabolic and nutritional profiles should be monitored in patients on a GFD.

Indexed as

Body Mass IndexAdultCeliac DiseaseComorbidityDiabetes Mellitus, Type 2Diet, Gluten-FreeFemaleHumansHypercholesterolemiaMaleMetabolic DiseasesNon-alcoholic Fatty Liver DiseaseNutritional Physiological PhenomenaBMIbody mass indexbody weightceliac diseasedyslipidemiagluten-free diethepatic steatosishypercholesterolemiahypertriglyceridemiaNAFLDNASHnonalcoholic fatty liver diseasenonalcoholic steatohepatitisT2DMtype 2 diabetes mellitus

Identifiers

PMID32231050
PMCPMC7230624
OpenAlexW3013028049

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.