ArticleInternational journal of environmental research and public health2020
Serum Uric Acid Level as a Harbinger of Type 2 Diabetes: A Prospective Observation in Taiwan.
Article in International journal of environmental research and public health, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 21 citations in OpenAlex.
- Uric Acid Variability Is Associated with Poor Prognosis in Heart Failure.Journal of clinical medicine · 2026Article
- Pediatric hyperuricemia: genetic basis, metabolic mechanisms, and clinical implications.Frontiers in endocrinology · 2026Review
- Association of Serum Uric Acid with Indices of Insulin Resistance: Proposal of a New Model with Reference to Gender Differences.Diabetes, metabolic syndrome and obesity : targets and therapy · 2024Article
- Relationship between baseline and changed serum uric acid and the incidence of type 2 diabetes mellitus: a national cohort study.Frontiers in public health · 2023Article
- Article
- Time course of serum uric acid accumulation and the risk of diabetes mellitus.Nutrition & diabetes · 2022Article
- Tea Consumption is Associated with an Increased Risk of Hyperuricemia in an Occupational Population in Guangdong, China.International journal of general medicine · 2022Article
- Tea consumption and serum uric acid levels among older adults in three large-scale population-based studies in China.BMC geriatrics · 2021Article
- Obesity-Induced Insulin Resistance Is Mediated by High Uric Acid in Obese Children and Adolescents.Frontiers in endocrinology · 2021Article
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCurrent evidence suggests an association of uric acid with diabetes risk, but it is still unclear whether uric acid is merely a risk marker or an independent risk factor. We evaluate the impact of serum uric acid (SUA) levels on the future risk of developing type 2 diabetes, independent of other factors.
methodsA population-based cohort study was conducted among 4130 participants who were found to be free of type 2 diabetes at baseline recruitment in 2002. Baseline SUA measured in 2002 was longitudinally related to the incident type 2 diabetes that occurred during the follow-up period between 2002 and 2007. Hazard ratios (HRs) and 95% confidence intervals (CIs) derived from Cox proportional hazards models were used to quantify the association.
resultsThere was a graded increase in the incidence of type 2 diabetes among individuals with increasing levels of SUA. In the whole study cohort, compared to quartile 1, the multivariable-adjusted HRs (95% CIs) of type 2 diabetes in quartile 2, quartile 3, and quartile 4 were 1.69 (0.76-3.76), 1.86 (0.88-4.26), and 1.94 (1.05-4.05), respectively (P for trend = 0.004). This positive gradient for the risk of type 2 diabetes across quartiles of SUA was evident in both genders and across age groups.
conclusionsThis study supports that high uric acid concentrations are associated with increased diabetes risk, independent of other known risk factors. These data expand on well-established associations between SUA level and metabolic syndrome, and extend the link to the future risk of type 2 diabetes.
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