ReviewInternational journal of molecular sciences2020
Subcellular Localization of Copper-Cellular Bioimaging with Focus on Neurological Disorders.
Review in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 54 citations in OpenAlex.
- CuET promotes cuproptosis and ferroptosis of lung cancer cells by interacting directly with polyunsaturated phospholipids.iScience · 2026Article
- Cell-specific copper dyshomeostasis mechanism in Alzheimer's disease.Translational neurodegeneration · 2025Review
- Ionic Liquid-Based Centrifuge-Less Cloud Point Extraction of a Copper(II)-4-Nitrocatechol Complex and Its Analytical Application.Molecules (Basel, Switzerland) · 2025Article
- Modern Bioimaging Techniques for Elemental Tissue Analysis: Key Parameters, Challenges and Medical Impact.Molecules (Basel, Switzerland) · 2025Review
- Cellular mechanisms of copper neurotoxicity in human, differentiated neurons.Archives of toxicology · 2025Article
- Identification of cuproptosis-related genes in septic shock based on bioinformatic analysis.PloS one · 2024Article
- Dysfunction in atox-1 and ceruloplasmin alters labile Cu levels and consequently Cu homeostasis inFrontiers in molecular biosciences · 2024Article
- A fluorometric assay to determine labile copper(II) ions in serum.Scientific reports · 2023Article
- Recent Advances in Nanopore Technology for Copper Detection and Their Potential Applications.Nanomaterials (Basel, Switzerland) · 2023Review
- Copper/Zinc Ratio in Childhood and Adolescence: A Review.Metabolites · 2023Review
- The Role of Copper Homeostasis in Brain Disease.International journal of molecular sciences · 2022Review
- Direct Cell Radiolabeling forChemical reviews · 2022Review
- Biometal Dyshomeostasis in Olfactory Mucosa of Alzheimer's Disease Patients.International journal of molecular sciences · 2022Article
- Dietary Copper Intake and Risk of Stroke in Adults: A Case-Control Study Based on National Health and Nutrition Examination Survey 2013-2018.Nutrients · 2022Article
- Dietary copper intake and the prevalence of kidney stones among adult in the United States: A propensity score matching study.Frontiers in public health · 2022Article
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- Silicon-based fluorescent platforms for copper(ii) detection in water.RSC advances · 2021Article
- Novel technical developments in mass spectrometry imaging in 2020: A mini review.Analytical science advances · 2021Review
- Application of Mass Spectrometry in Pancreatic Cancer Translational Research.Frontiers in oncology · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
As an essential trace element, copper plays a pivotal role in physiological body functions. In fact, dysregulated copper homeostasis has been clearly linked to neurological disorders including Wilson and Alzheimer's disease. Such neurodegenerative diseases are associated with progressive loss of neurons and thus impaired brain functions. However, the underlying mechanisms are not fully understood. Characterization of the element species and their subcellular localization is of great importance to uncover cellular mechanisms. Recent research activities focus on the question of how copper contributes to the pathological findings. Cellular bioimaging of copper is an essential key to accomplish this objective. Besides information on the spatial distribution and chemical properties of copper, other essential trace elements can be localized in parallel. Highly sensitive and high spatial resolution techniques such as LA-ICP-MS, TEM-EDS, S-XRF and NanoSIMS are required for elemental mapping on subcellular level. This review summarizes state-of-the-art techniques in the field of bioimaging. Their strengths and limitations will be discussed with particular focus on potential applications for the elucidation of copper-related diseases. Based on such investigations, further information on cellular processes and mechanisms can be derived under physiological and pathological conditions. Bioimaging studies might enable the clarification of the role of copper in the context of neurodegenerative diseases and provide an important basis to develop therapeutic strategies for reduction or even prevention of copper-related disorders and their pathological consequences.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.