Evidence map›Paper›PMID 32230960›Full record

ArticleBiomolecules2020

The Antioxidant Peptide Salamandrin-I: First Bioactive Peptide Identified from Skin Secretion of Salamandra Genus (Salamandra salamandra).

Alexandra Plácido, João Bueno, Eder A Barbosa, Daniel C Moreira, Jhones do Nascimento Dias, Wanessa Felix Cabral, Patrícia Albuquerque, Lucinda J Bessa, Jaime Freitas, Selma A S Kuckelhaus and 6 more

Abstract read
In one paragraph

Article in Biomolecules, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Article
  2. Review
  3. Blunt-Nosed Viper (ACS omega · 2025
    Article
  4. Article
  5. Review
  6. Article
  7. Article
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  14. Article
  15. Revisiting the hydroxylation phenomenon of SiOJournal of molecular modeling · 2022
    Article
  16. Article
  17. Article
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Alexandra PlácidoLAQV/REQUIMTE, Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, 4169-007 Porto, Portugal.
João BuenoCenter for Research in Applied Morphology and Immunology, NuPMIA, University of Brasilia, Brasilia 70910-900, DF, Brazil.
Eder A BarbosaLaboratory for the Synthesis and Analysis of Biomolecules (LSAB), Institute of Chemistry, University of Brasília, Brasília 70910-900, DF, Brazil.
Daniel C MoreiraCenter for Research in Applied Morphology and Immunology, NuPMIA, University of Brasilia, Brasilia 70910-900, DF, Brazil.
Jhones do Nascimento DiasLaboratory of Molecular Biology of Fungal Pathogens, Department of Cell Biology, Institute of Biological Sciences, University of Brasília, Brasília 70910-900, DF, Brazil.
Wanessa Felix CabralCenter for Research in Applied Morphology and Immunology, NuPMIA, University of Brasilia, Brasilia 70910-900, DF, Brazil.
Patrícia AlbuquerqueLaboratory of Molecular Biology of Fungal Pathogens, Department of Cell Biology, Institute of Biological Sciences, University of Brasília, Brasília 70910-900, DF, Brazil.
Lucinda J BessaLAQV/REQUIMTE, Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, 4169-007 Porto, Portugal.
Jaime FreitasInstitute for Research and Innovation in Health (i3S) and National Institute of Biomedical Engineering (INEB), 4200-135 Porto, Portugal.
Selma A S KuckelhausCenter for Research in Applied Morphology and Immunology, NuPMIA, University of Brasilia, Brasilia 70910-900, DF, Brazil.
Filipe C D A LimaFederal Institute of Education, Science and Technology of São Paulo, Campus Matão, 15991-502 Matão, SP, Brazil.
Augusto Batagin-NetoSão Paulo State University (UNESP), Campus of Itapeva, 18409-010 Itapeva, SP, Brazil.
Guilherme D BrandLaboratory for the Synthesis and Analysis of Biomolecules (LSAB), Institute of Chemistry, University of Brasília, Brasília 70910-900, DF, Brazil.
João B RelvasInstitute for Research and Innovation in Health (i3S) and Institute for Molecular and Cell Biology (IBMC), 4200-135 Porto, Portugal.
José Roberto S A LeiteLAQV/REQUIMTE, Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, 4169-007 Porto, Portugal.
Peter EatonLAQV/REQUIMTE, Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, 4169-007 Porto, Portugal.

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 420449/2018-3Conselho Nacional de Desenvolvimento Científico e Tecnológico 428211/2018-6Fundação para a Ciência e a Tecnologia 31158/2017
6 · The paper itself

Abstract

Amphibian skin is a multifunctional organ that plays key roles in defense, breathing, and water balance. In this study, skin secretion samples of the fire salamander (Salamandra salamandra) were separated using RP-HPLC and de novo sequenced using MALDI-TOF MS/MS. Next, we used an in silico platform to screen antioxidant molecules in the framework of density functional theory. One of the identified peptides, salamandrin-I, [M + H]

Indexed as

SalamandraAmphibian ProteinsAnimalsAnti-Bacterial AgentsAntioxidantsCircular DichroismDrug Evaluation, PreclinicalHumansMicrobial Sensitivity TestsMothsPeptidesSkinToxicity TestsAmphibian ProteinsAnti-Bacterial AgentsAntioxidantsPeptidesantioxidant peptidesbioactive moleculesportuguese biodiversitySalamandra salamandra

Identifiers

PMID32230960
PMCPMC7226163

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.