Evidence map›Paper›PMID 32230951›Full record

ArticleNutrients2020

Isolation of Anti-Inflammatory and Epithelium Reinforcing

Kaisa Hiippala, Veera Kainulainen, Maiju Suutarinen, Tuomas Heini, Jolene R Bowers, Daniel Jasso-Selles, Darrin Lemmer, Michael Valentine, Riley Barnes, David M Engelthaler and 1 more

Open access · goldAbstract read
In one paragraph

Article in Nutrients, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 86 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
86citing papers in PubMed, 1 pooled it
8.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

86 citing papers in PubMed, 1 synthesis or guideline pooled it, 154 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Trending ileal microbiome dysbiosis over time as an early assessment of intestinal transplant rejection risk.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2026
    Article
  6. Article
  7. Article
  8. Chemical science · 2026
    Article
  9. Journal of microbiology and biotechnology · 2026
    Article
  10. Foods (Basel, Switzerland) · 2026
    Article
  11. Dual immunomodulatory effects ofFrontiers in microbiology · 2026
    Article
  12. Effect of probioticBioscience of microbiota, food and health · 2026
    Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Nutrients · 2025
    Article
  20. Animals : an open access journal from MDPI · 2025
    Article

26 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Kaisa HiippalaHuman Microbiome Research Program, Faculty of Medicine, University of Helsinki, 00290 Helsinki, Finland.
Veera KainulainenHuman Microbiome Research Program, Faculty of Medicine, University of Helsinki, 00290 Helsinki, Finland.ORCID 0000-0002-4557-9605
Maiju SuutarinenHuman Microbiome Research Program, Faculty of Medicine, University of Helsinki, 00290 Helsinki, Finland.
Tuomas HeiniHuman Microbiome Research Program, Faculty of Medicine, University of Helsinki, 00290 Helsinki, Finland.
Jolene R BowersTranslational Genomics Research Institute, Pathogen and Microbiome Division, Flagstaff, AZ 86001, USA.
Daniel Jasso-SellesTranslational Genomics Research Institute, Pathogen and Microbiome Division, Flagstaff, AZ 86001, USA.
Darrin LemmerTranslational Genomics Research Institute, Pathogen and Microbiome Division, Flagstaff, AZ 86001, USA.
Michael ValentineTranslational Genomics Research Institute, Pathogen and Microbiome Division, Flagstaff, AZ 86001, USA.
Riley BarnesTranslational Genomics Research Institute, Pathogen and Microbiome Division, Flagstaff, AZ 86001, USA.
David M EngelthalerTranslational Genomics Research Institute, Pathogen and Microbiome Division, Flagstaff, AZ 86001, USA.
Reetta SatokariHuman Microbiome Research Program, Faculty of Medicine, University of Helsinki, 00290 Helsinki, Finland.
Translational Genomics Research Institute · USUniversity of Helsinki · FI

Funding

Academy of Finland 285632Academy of Finland 304490Academy of Finland 323156Sigrid Juséliuksen Säätiö Reetta Satokari
6 · The paper itself

Abstract

Altered intestinal microbiota is associated with systemic and intestinal diseases, such as inflammatory bowel disease (IBD). Dysbiotic microbiota with enhanced proinflammatory capacity is characterized by depletion of anaerobic commensals, increased proportion of facultatively anaerobic bacteria, as well as reduced diversity and stability. In this study, we developed a high-throughput in vitro screening assay to isolate intestinal commensal bacteria with anti-inflammatory capacity from a healthy fecal microbiota transplantation donor. Freshly isolated gut bacteria were screened for their capacity to attenuate

Indexed as

BacteroidesAdultAnti-Inflammatory AgentsBacteroidetesCaco-2 CellsFecesFemaleGastrointestinal MicrobiomeHigh-Throughput Screening AssaysHomeostasisHumansInterleukin-8LipopolysaccharidesProbioticsAnti-Inflammatory AgentsInterleukin-8Lipopolysaccharidesbacteroidesgut homeostasishost-microbe interactionsimmunomodulationLPSnext-generation probiotics

Identifiers

PMID32230951
PMCPMC7230855
OpenAlexW3013957578

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.