Evidence map›Paper›PMID 32230928›Full record

ArticleBiomolecules2020

An Extract of Transgenic Senna obtusifolia L. Hairy Roots with Overexpression of PgSS1 Gene in Combination with Chemotherapeutic Agent Induces Apoptosis in the Leukemia Cell Line.

Tomasz Kowalczyk, Przemysław Sitarek, Monika Toma, Laurent Picot, Marzena Wielanek, Ewa Skała, Tomasz Śliwiński

Open access · goldAbstract read
In one paragraph

Article in Biomolecules, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. New Data on Anti-Inflammatory and Wound Healing Potential of TransgenicInternational journal of molecular sciences · 2023
    Article
  3. Review
  4. Review
  5. Pro-Apoptotic Potential ofPharmaceutics · 2021
    Article
  6. Article
  7. Article
  8. Obtusifolin, an Anthraquinone Extracted fromPharmaceuticals (Basel, Switzerland) · 2021
    Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Tomasz KowalczykDepartment of Molecular Biotechnology and Genetics, University of Lodz, Banacha 12/16, 90-237 Lodz, Poland.
Przemysław SitarekDepartment of Biology and Pharmaceutical Botany, Medical University of Lodz, Muszynskiego 1, 90-151 Lodz, Poland.
Monika TomaLaboratory of Medical Genetics, Faculty of Biology and Environmental Protection, University of Lodz, 90-236 Lodz, Poland.
Laurent PicotLa Rochelle Université, UMRi CNRS 7266 LIENSs, Faculté des Sciences et Technologies, F-17042 La Rochelle CEDEX 1, France.
Marzena WielanekDepartment of Plant Physiology and Biochemistry, Faculty of Biology and Environmental Protection, University of Lodz, Banacha 12/16, 90-237, Lodz, Poland.
Ewa SkałaDepartment of Biology and Pharmaceutical Botany, Medical University of Lodz, Muszynskiego 1, 90-151 Lodz, Poland.
Tomasz ŚliwińskiLaboratory of Medical Genetics, Faculty of Biology and Environmental Protection, University of Lodz, 90-236 Lodz, Poland.
University of Łódź · PLMedical University of Lodz · PLCentre National de la Recherche Scientifique · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Many biologically-active plant-derived compounds have therapeutic or chemopreventive effects. The use of plant in vitro cultures in conjunction with modern genetic engineering techniques allows greater amounts of valuable secondary metabolites to be obtained without interfering with the natural environment. This work presents the first findings concerning the acquisition of transgenic hairy roots of

Indexed as

Antineoplastic Agents, PhytogenicApoptosisBetulinic AcidDoxorubicinFarnesyl-Diphosphate FarnesyltransferaseGene Expression ProfilingGene Expression Regulation, LeukemicGreen Fluorescent ProteinsHumansLeukemiaMembrane Potential, MitochondrialPanaxPentacyclic TriterpenesPlant ProteinsPlant RootsPlants, Genetically ModifiedAntineoplastic Agents, PhytogenicBetulinic AcidDoxorubicinFarnesyl-Diphosphate FarnesyltransferaseGreen Fluorescent ProteinsPentacyclic TriterpenesPlant ProteinsSenna Extractanticancer propertiesbetulinic acidNALM6 leukemia cell lineSenna obtusifoliatransgenic hairy roots

Identifiers

PMID32230928
PMCPMC7226363
OpenAlexW3013784609

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.