Evidence map›Paper›PMID 32230871›Full record

ReviewInternational journal of molecular sciences2020

Detection of Rare Objects by Flow Cytometry: Imaging, Cell Sorting, and Deep Learning Approaches.

Denis V Voronin, Anastasiia A Kozlova, Roman A Verkhovskii, Alexey V Ermakov, Mikhail A Makarkin, Olga A Inozemtseva, Daniil N Bratashov

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 44 citations in OpenAlex.

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  12. Cell Reprogramming With CRISPR/Cas9 Based Transcriptional Regulation Systems.Frontiers in bioengineering and biotechnology · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Denis V VoroninLaboratory of Biomedical Photoacoustics, Saratov State University, 410012 Saratov, Russia.ORCID 0000-0002-1960-6737
Anastasiia A KozlovaLaboratory of Biomedical Photoacoustics, Saratov State University, 410012 Saratov, Russia.ORCID 0000-0002-9336-0317
Roman A VerkhovskiiLaboratory of Biomedical Photoacoustics, Saratov State University, 410012 Saratov, Russia.ORCID 0000-0003-1830-4582
Alexey V ErmakovLaboratory of Biomedical Photoacoustics, Saratov State University, 410012 Saratov, Russia.
Mikhail A MakarkinLaboratory of Biomedical Photoacoustics, Saratov State University, 410012 Saratov, Russia.
Olga A InozemtsevaLaboratory of Biomedical Photoacoustics, Saratov State University, 410012 Saratov, Russia.
Daniil N BratashovLaboratory of Biomedical Photoacoustics, Saratov State University, 410012 Saratov, Russia.ORCID 0000-0002-2096-4478
Saratov State University · RUGubkin Russian State University of Oil and Gas · RU

Funding

Russian Science Foundation 18-19-00354
6 · The paper itself

Abstract

Flow cytometry nowadays is among the main working instruments in modern biology paving the way for clinics to provide early, quick, and reliable diagnostics of many blood-related diseases. The major problem for clinical applications is the detection of rare pathogenic objects in patient blood. These objects can be circulating tumor cells, very rare during the early stages of cancer development, various microorganisms and parasites in the blood during acute blood infections. All of these rare diagnostic objects can be detected and identified very rapidly to save a patient's life. This review outlines the main techniques of visualization of rare objects in the blood flow, methods for extraction of such objects from the blood flow for further investigations and new approaches to identify the objects automatically with the modern deep learning methods.

Indexed as

Deep LearningAutomationBlood CirculationCell SeparationCell TrackingDiagnostic ImagingDiagnostic Tests, RoutineFlow CytometryFluorescent DyesHematologic DiseasesHumansMagneticsNeoplastic Cells, CirculatingRare DiseasesStaining and LabelingFluorescent Dyescell labelingcell sortingcirculating tumor cellsdeep learningflow cytometry data analysisimaging flow cytometryliquid biopsy

Identifiers

PMID32230871
PMCPMC7177904
OpenAlexW3013335580

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.