ArticleMolecules (Basel, Switzerland)2020
Cognitive Facilitation and Antioxidant Effects of an Essential Oil Mix on Scopolamine-Induced Amnesia in Rats: Molecular Modeling of In Vitro and In Vivo Approaches.
Article in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 48 citations in OpenAlex.
- Anti-inflammatory and antioxidant effects of Lavandula stoechas L. on human macrophages and in silico prediction of α7 nicotinic acetylcholine receptor interaction.BMC complementary medicine and therapies · 2026Article
- Neuroprotective Effects of Citropten Against Scopolamine-Induced Cognitive Impairment and Oxidative Stress in a Rat Model.Neurochemical research · 2026Article
- Therapeutic Efficacy ofPharmaceuticals (Basel, Switzerland) · 2024Article
- New curcumin-loaded nanocapsules as a therapeutic alternative in an amnesia model.Metabolic brain disease · 2024Article
- Deciphering Neuroprotective Effect ofCurrent drug targets · 2024Review
- Elaboration of the Effective Multi-Target Therapeutic Platform for the Treatment of Alzheimer's Disease Based on Novel Monoterpene-Derived Hydroxamic Acids.International journal of molecular sciences · 2023Article
- Natural essential oils derived from herbal medicines: A promising therapy strategy for treating cognitive impairment.Frontiers in aging neuroscience · 2023Review
- Ex Vivo Antioxidant and Cholinesterase Inhibiting Effects of a Novel Galantamine-Curcumin Hybrid on Scopolamine-Induced Neurotoxicity in Mice.International journal of molecular sciences · 2022Article
- Review
- Attenuation of Scopolamine-Induced Amnesia via Cholinergic Modulation in Mice by Synthetic Curcumin Analogs.Molecules (Basel, Switzerland) · 2022Article
- Neuroprotective potential of terpenoid-rich extracts from orange juice by-products obtained by pressurized liquid extraction.Food chemistry: X · 2022Article
- Comparative Studies on Essential Oil and Phenolic Content with In Vitro Antioxidant, Anticholinesterase, Antimicrobial Activities ofMolecules (Basel, Switzerland) · 2022Article
- Effect of Sanguisorba minor on scopolamine-induced memory loss in rat: involvement of oxidative stress and acetylcholinesterase.Metabolic brain disease · 2022Article
- The improvement ofFrontiers in pharmacology · 2022Article
- Protective effect ofFrontiers in pharmacology · 2022Article
- Mechanistic Aspects of Apiaceae Family Spices in Ameliorating Alzheimer's Disease.Antioxidants (Basel, Switzerland) · 2021Review
- Neuroprotective Potential of Limonene and Limonene Containing Natural Products.Molecules (Basel, Switzerland) · 2021Review
- Activity of Selected Group of Monoterpenes in Alzheimer's Disease Symptoms in Experimental Model Studies-A Non-Systematic Review.International journal of molecular sciences · 2021Review
- The Antioxidant Activity of Limonene Counteracts Neurotoxicity Triggered byAβAntioxidants (Basel, Switzerland) · 2021Article
- Smell and Stress Response in the Brain: Review of the Connection between Chemistry and Neuropharmacology.Molecules (Basel, Switzerland) · 2021Review
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
The present study investigated the capability of an essential oil mix (MO: 1% and 3%) in ameliorating amnesia and brain oxidative stress in a rat model of scopolamine (Sco) and tried to explore the underlying mechanism. The MO was administered by inhalation to rats once daily for 21 days, while Sco (0.7 mg/kg) treatment was delivered 30 min before behavioral tests. Donepezil (DP: 5 mg/kg) was used as a positive reference drug. The cognitive-enhancing effects of the MO in the Sco rat model were assessed in the Y-maze, radial arm maze (RAM), and novel object recognition (NOR) tests. As identified by gas chromatography-mass spectrometry (GC-MS), the chemical composition of the MO is comprised by limonene (91.11%), followed by γ-terpinene (2.02%), β-myrcene (1.92%), β-pinene (1.76%), α-pinene (1.01%), sabinene (0.67%), linalool (0.55%), cymene (0.53%), and valencene (0.43%). Molecular interactions of limonene as the major compound in MO with the active site of butyrylcholinesterase (BChE) was explored via molecular docking experiments, and Van der Waals (vdW) contacts were observed between limonene and the active site residues SER198, HIS438, LEU286, VAL288, and PHE329. The brain oxidative status and acetylcholinesterase (AChE) and BChE inhibitory activities were also determined. MO reversed Sco-induced memory deficits and brain oxidative stress, along with cholinesterase inhibitory effects, which is an important mechanism in the anti-amnesia effect. Our present findings suggest that MO ameliorated memory impairment induced by Sco via restoration of the cholinergic system activity and brain antioxidant status.
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