ArticleInternational journal of molecular sciences2020
Tailored PCL Scaffolds as Skin Substitutes Using Sacrificial PVP Fibers and Collagen/Chitosan Blends.
Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Stimuli-Responsive Self-Healing Ionic Gels: A Promising Approach for Dermal and Tissue Engineering Applications.ACS biomaterials science & engineering · 2025Review
- Article
- Electrospun Polycaprolactone Membranes Expanded with Chitosan Granules for Cell Infiltration.Polymers · 2024Article
- State-of-the-Art Review of Advanced Electrospun Nanofiber Composites for Enhanced Wound Healing.AAPS PharmSciTech · 2023Review
- Chitosan Based Materials in Cosmetic Applications: A Review.Molecules (Basel, Switzerland) · 2023Review
- Comparison of biopolymer scaffolds for the fabrication of skin substitutes in a porcine wound model.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society · 2023Article
- 3D scaffolds of caprolactone/chitosan/polyvinyl alcohol/hydroxyapatite stabilized by physical bonds seeded with swine dental pulp stem cell for bone tissue engineering.Journal of materials science. Materials in medicine · 2022Article
- Effect of Chitosan Deacetylation on Its Affinity to Type III Collagen: A Molecular Dynamics Study.Materials (Basel, Switzerland) · 2022Article
- Bioactive Collagen Hydrolysate-Chitosan/Essential Oil Electrospun Nanofibers Designed for Medical Wound Dressings.Pharmaceutics · 2021Article
- Nanomaterials for Biomedical Applications: Production, Characterisations, Recent Trends and Difficulties.Molecules (Basel, Switzerland) · 2021Review
- Collagen I Induces Preeclampsia-Like Symptoms by Suppressing Proliferation and Invasion of Trophoblasts.Frontiers in endocrinology · 2021Article
- Design Challenges in Polymeric Scaffolds for Tissue Engineering.Frontiers in bioengineering and biotechnology · 2021Review
- Different Conditions for the Modification of Polycaprolactone Films with L-Arginine.International journal of molecular sciences · 2020Article
- Electrospun Fibers and Sorbents as a Possible Basis for Effective Composite Wound Dressings.Micromachines · 2020Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Electrospinning is a versatile technique for fabrication of made-on-purpose biomimetic scaffolds. In this study, optimized electrospun fibrous membranes were produced by simultaneous electrospinning of polycaprolactone (PCL) and polyvinylpyrrolidone (PVP), followed by the selective removal of PVP from the PCL/PVP mesh. After aminolysis, a blend of collagen/chitosan was grafted on the surface. Physicochemical characterizations as well as in vitro evaluations were conducted using different methods. Successful cell infiltration into samples was observed. It seems that the positive trend of cell ingress originates from the proper pore size obtained after removal of pvp (from 4.46 μm before immersion in water to 33.55 μm after immersion in water for 24 h). Furthermore, grafting the surface with the collagen/chitosan blend rendered the scaffolds more biocompatible with improved attachment and spreading of keratinocyte cell lines (HaCaT). Viability evaluation through MTT assay for HDF cells did not reveal any cytotoxic effects. Antibacterial assay with
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