Evidence map›Paper›PMID 32229732›Full record

ArticleAmerican journal of nephrology2020

Coronavirus Disease 19 Infection Does Not Result in Acute Kidney Injury: An Analysis of 116 Hospitalized Patients from Wuhan, China.

Luwen Wang, Xun Li, Hui Chen, Shaonan Yan, Dong Li, Yan Li, Zuojiong Gong

Registry-linked trialOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of nephrology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04799600 (The Effect of the Severity of COVID-19 Disease on the Incidence of Acute Renal Failure in ICU), which is not on this map. Cited by 227 papers, 28 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
227citing papers in PubMed, 28 pooled it
11.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04799600 completednot on this map

The Effect of the Severity of COVID-19 Disease on the Incidence of Acute Renal Failure in ICU

TypeobservationalSponsorAnkara City Hospital BilkentRan2020 to 2021Enrolled158ConditionsCOVID19, Acute Renal FailureArmsBRESCİA-COVİD Respiratory Severity Scale
3 · Its place in the literature

Who cites it

227 citing papers in PubMed, 28 syntheses or guidelines pooled it, 463 citations in OpenAlex.

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167 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Luwen WangDepartment of Infectious Diseases, Renmin Hospital of Wuhan University, Wuhan, China.
Xun LiDepartment of Infectious Diseases, Renmin Hospital of Wuhan University, Wuhan, China.
Hui ChenInstitute of Infectious Diseases, Hubei Provincial Center for Disease Control and Prevention, Wuhan, China.
Shaonan YanDepartment of Infectious Diseases, Renmin Hospital of Wuhan University, Wuhan, China.
Dong LiDepartment of Laboratory Medicine, Renmin Hospital of Wuhan University, Wuhan, China.
Yan LiDepartment of Laboratory Medicine, Renmin Hospital of Wuhan University, Wuhan, China.
Zuojiong GongDepartment of Infectious Diseases, Renmin Hospital of Wuhan University, Wuhan, China, zjgong@163.com.
Wuhan University · CNRenmin Hospital of Wuhan University · CNHubei Provincial Center for Disease Control and Prevention · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWhether the patients with coronavirus disease 19 (COVID-19) infected by severe acute respiratory syndrome (SARS)-CoV-2 would commonly develop acute kidney injury (AKI) is an important issue worthy of clinical attention. This study aimed to explore the effects of SARS-CoV-2 infection on renal function through analyzing the clinical data of 116 hospitalized COVID-19-confirmed patients.

methodsOne hundred sixteen COVID-19-confirmed patients enrolled in this study were hospitalized in the Department of Infectious Diseases, Renmin Hospital of Wuhan University from January 14 to February 13, 2020. The recorded information includes demographic data, medical history, contact history, potential comorbidities, symptoms, signs, laboratory test results, chest computer tomography scans, and treatment measures. SARS-CoV-2 RNA in 53 urine sediments of enrolled patients was detected by real-time reverse transcription-polymerase chain reaction.

resultsTwelve (10.8%) patients showed mild increase of blood urea nitrogen or creatinine (<26 μmol/L within 48 h), and 8 (7.2%) patients showed trace or 1+ albuminuria in 111 COVID-19-confirmed patients without chronic kidney disease (CKD). All these patients did not meet the diagnostic criteria of AKI. In addition, 5 patients with CKD who were undergone regular continuous renal replacement therapy (CRRT) before admission were confirmed infection of SARS-CoV-2 and diagnosed as COVID-19. In addition to therapy for COVID-19, CRRT was also applied 3 times weekly during hospitalization for these 5 patients with CKD. In the course of treatment, the renal function indicators showed stable state in all 5 patients with CKD, without exacerbation of CKD, and pulmonary inflammation was gradually absorbed. All 5 patients with CKD were survived. Moreover, SARS-CoV-2 RNA in urine sediments was positive only in 3 patients from 48 cases without CKD, and 1 patient had a positive for SARS-CoV-2 open reading frame 1ab from 5 cases with CKD.

conclusionAKI was uncommon in COVID-19. SARS-CoV-2 infection does not result in AKI, or aggravate CKD in the COVID-19 patients.

Indexed as

BetacoronavirusCoronavirus InfectionsKidney DiseasesPandemicsPneumonia, ViralAcute DiseaseAdultAgedAged, 80 and overChinaCOVID-19FemaleHospitalizationHumansKidney Function TestsMaleAcute kidney injuryChronic kidney diseaseContinuous renal replacement therapyCoronavirus disease 19Severe acute respiratory syndrome-CoV-2

Identifiers

PMID32229732
PMCPMC7179524
OpenAlexW3013972963

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.