Evidence map›Paper›PMID 32229601›Full record

ArticleJournal of clinical microbiology2020

Multicenter Evaluation of QIAstat-Dx Respiratory Panel V2 for Detection of Viral and Bacterial Respiratory Pathogens.

Stefan A Boers, Willem J G Melchers, Cas J A Peters, Marga Toonen, Martin P McHugh, Kate E Templeton, Eric C J Claas

Open access · hybridAbstract readMulticenter Study
In one paragraph

Article in Journal of clinical microbiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.

  1. Pooled it
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  5. Review
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  8. Review
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  15. Performance evaluation of the QIAstat-Dx® Respiratory SARS-CoV-2 Panel.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2021
    Observational
  16. Recent Advancements on COVID-19: A Comprehensive Review.International journal of general medicine · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Stefan A BoersDepartment of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands.
Willem J G MelchersDepartment of Medical Microbiology, Radboud University Medical Center, Nijmegen, The Netherlands.
Cas J A PetersDepartment of Medical Microbiology, Radboud University Medical Center, Nijmegen, The Netherlands.
Marga ToonenDepartment of Medical Microbiology, Radboud University Medical Center, Nijmegen, The Netherlands.
Martin P McHughDepartment of Medical Microbiology, Royal Infirmary of Edinburgh, Edinburgh, United Kingdom.ORCID 0000-0002-0370-3700
Kate E TempletonDepartment of Medical Microbiology, Royal Infirmary of Edinburgh, Edinburgh, United Kingdom.
Eric C J ClaasDepartment of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands e.c.j.claas@lumc.nl.
Radboud University Nijmegen · NLEdinburgh Royal Infirmary · GBLeiden University Medical Center · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

QIAstat-Dx Respiratory Panel V2 (RP) is a novel molecular-method-based syndromic test for the simultaneous and rapid (∼70-min) detection of 18 viral and 3 bacterial pathogens causing respiratory infections. This report describes the first multicenter retrospective comparison of the performance of the QIAstat-Dx RP assay to the established ePlex Respiratory Pathogen Panel (RPP) assay, for which we used 287 respiratory samples from patients suspected with respiratory infections. The QIAstat-Dx RP assay detected 312 (92%) of the 338 respiratory targets that were detected by the ePlex RPP assay. Most of the discrepant results have been observed in the low-pathogen-load samples. In addition, the QIAstat-Dx RP assay detected 19 additional targets in 19 respiratory samples that were not detected by the ePlex RPP assay. Nine of these discordant targets were considered to represent true positives after discrepancy testing by a third method. The main advantage of the QIAstat-Dx system compared to other syndromic testing systems, including the ePlex RPP assay, is the ability to generate cycle threshold (

Indexed as

Molecular Diagnostic TechniquesRespiratory Tract InfectionsBacteriaDiagnostic Tests, RoutineHumansRetrospective StudiesePlexmolecular diagnosticsQIAstat-Dxrespiratory pathogen panelrespiratory tract infectionssyndromic testing

Identifiers

PMID32229601
PMCPMC7269373
OpenAlexW3013493168

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.