Evidence map›Paper›PMID 32229565›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2020

Wild chimpanzees exhibit humanlike aging of glucocorticoid regulation.

Melissa Emery Thompson, Stephanie A Fox, Andreas Berghänel, Kris H Sabbi, Sarah Phillips-Garcia, Drew K Enigk, Emily Otali, Zarin P Machanda, Richard W Wrangham, Martin N Muller

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
4.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 56 citations in OpenAlex.

  1. Minimal Evidence of Inflammaging in Naturalistic Chimpanzee Populations.American journal of biological anthropology · 2026
    Article
  2. Article
  3. Article
  4. Circadian clock communication during homeostasis and ageing.Nature reviews. Molecular cell biology · 2025
    Review
  5. Article
  6. Article
  7. Wild capuchin monkeys as a model system for investigating the social and ecological determinants of ageing.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024
    Review
  8. Article
  9. Article
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  12. Review
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  14. Article
  15. Article
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  17. Article
  18. Minimally invasive biomarkers in human and non-human primate evolutionary biology: Tools for understanding variation and adaptation.American journal of human biology : the official journal of the Human Biology Council · 2022
    Article
  19. Evolutionary Approaches in Aging Research.Cold Spring Harbor perspectives in medicine · 2022
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 3 countries.

Melissa Emery ThompsonDepartment of Anthropology, University of New Mexico, Albuquerque, NM 87131; memery@unm.edu.ORCID 0000-0003-2451-6397
Stephanie A FoxDepartment of Anthropology, University of New Mexico, Albuquerque, NM 87131.
Andreas BerghänelDepartment of Anthropology, University of New Mexico, Albuquerque, NM 87131.
Kris H SabbiDepartment of Anthropology, University of New Mexico, Albuquerque, NM 87131.
Sarah Phillips-GarciaDepartment of Anthropology, University of New Mexico, Albuquerque, NM 87131.ORCID 0000-0001-6857-5888
Drew K EnigkDepartment of Anthropology, University of New Mexico, Albuquerque, NM 87131.ORCID 0000-0002-5071-8825
Emily OtaliKibale Chimpanzee Project, Fort Portal, Uganda.
Zarin P MachandaKibale Chimpanzee Project, Fort Portal, Uganda.
Richard W WranghamKibale Chimpanzee Project, Fort Portal, Uganda.
Martin N MullerDepartment of Anthropology, University of New Mexico, Albuquerque, NM 87131.
University of New Mexico · USHarvard University · USKibale Chimpanzee Project · UGTufts University · USUniversity of Veterinary Medicine Vienna · AT

Funding

Molecular Epidemiology and Natural History of SIVcpzR01AI058715 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI HAHN, BEATRICE H · 2004 to 2013
$6.1M
Cumulative Life Course Effects on Aging and Health in a Long-Lived Primate ModelR37AG049395 · NIA · UNIVERSITY OF NEW MEXICO · PI Elizabeth Vinson Lonsdorf, Melissa Emery Thompson · 2022 to 2026
$3.2M
Biodemography of Aging in Wild ChimpanzeesR01AG049395 · NIA · UNIVERSITY OF NEW MEXICO · PI MITANI, JOHN CARY, ROSATI, ALEXANDRA G · 2015 to 2019
$2.9M
NIAID NIH HHS R01 AI058715NIA NIH HHS R01 AG049395NIA NIH HHS R37 AG049395
6 · The paper itself

Abstract

Cortisol, a key product of the stress response, has critical influences on degenerative aging in humans. In turn, cortisol production is affected by senescence of the hypothalamic-pituitary-adrenal (HPA) axis, leading to progressive dysregulation and increased cortisol exposure. These processes have been studied extensively in industrialized settings, but few comparative data are available from humans and closely related species living in natural environments, where stressors are very different. Here, we examine age-related changes in urinary cortisol in a 20-y longitudinal study of wild chimpanzees (

Indexed as

AgingAnimalsDisease Models, AnimalFemaleGlucocorticoidsHumansHydrocortisoneLongevityLongitudinal StudiesMalePan troglodytesGlucocorticoidsHydrocortisonecircadian rhythmsglucocorticoidsprimatessenescencestress

Identifiers

PMID32229565
PMCPMC7165472
OpenAlexW3013139947

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.