Evidence map›Paper›PMID 32229564›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2020

Autologous transplantation of spermatogonial stem cells restores fertility in congenitally infertile mice.

Mito Kanatsu-Shinohara, Narumi Ogonuki, Shogo Matoba, Atsuo Ogura, Takashi Shinohara

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
4.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 36 citations in OpenAlex.

  1. Male germ cell technologies in large animals.The Journal of reproduction and development · 2026
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  17. Frontiers in endocrinology · 2022
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  20. Is It Possible to Treat Infertility with Stem Cells?Reproductive sciences (Thousand Oaks, Calif.) · 2021
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Mito Kanatsu-ShinoharaDepartment of Molecular Genetics, Graduate School of Medicine, Kyoto University, 606-8501 Kyoto, Japan.
Narumi OgonukiInstitute for Physical and Chemical Research (RIKEN), BioResource Research Center, 305-0074 Tsukuba, Japan.
Shogo MatobaInstitute for Physical and Chemical Research (RIKEN), BioResource Research Center, 305-0074 Tsukuba, Japan.ORCID 0000-0003-0474-232X
Atsuo OguraInstitute for Physical and Chemical Research (RIKEN), BioResource Research Center, 305-0074 Tsukuba, Japan.
Takashi ShinoharaDepartment of Molecular Genetics, Graduate School of Medicine, Kyoto University, 606-8501 Kyoto, Japan; tshinoha@virus.kyoto-u.ac.jp.ORCID 0000-0002-9613-7022
RIKEN BioResource Research Center · JPKyoto University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The blood-testis barrier (BTB) is thought to be indispensable for spermatogenesis because it creates a special environment for meiosis and protects haploid cells from the immune system. The BTB divides the seminiferous tubules into the adluminal and basal compartments. Spermatogonial stem cells (SSCs) have a unique ability to transmigrate from the adluminal compartment to the basal compartment through the BTB upon transplantation into the seminiferous tubule. Here, we analyzed the role of

Indexed as

Stem Cell TransplantationAnimalsDisease Models, AnimalFertilityHumansInfertilityMaleMiceSpermatogenesisSpermatogoniaSpermatozoaStem CellsTransplantation, AutologousclaudinSertoli cellspermatogenesis

Identifiers

PMID32229564
PMCPMC7149444
OpenAlexW3013012291

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.