ArticleJournal of immunology (Baltimore, Md. : 1950)2020
Cytomegalovirus Coinfection Is Associated with Increased Vascular-Homing CD57
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Article in Journal of immunology (Baltimore, Md. : 1950), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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25citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
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Who cites it
25 citing papers in PubMed, 36 citations in OpenAlex.
- Cytotoxic CX3CR1+ Vδ1 T cells clonally expand in an interplay of CMV, microbiota, and HIV-1 persistence in people on antiretroviral therapy.PLoS pathogens · 2025Trial
- Review
- RhCMV expands CCR5+ memory T cells and promotes SIV reservoir seeding in the gut mucosa.JCI insight · 2026Article
- The potential role of trained immunity in HIV-associated atherosclerotic cardiovascular disease: mechanisms and therapeutic implications.Frontiers in immunology · 2026Review
- Mouse Models of HIV-Associated Atherosclerosis.International journal of molecular sciences · 2025Review
- Targeting PD-1 and CD85j can restore intratumoral CD4Journal for immunotherapy of cancer · 2025Article
- Cytomegalovirus Antibodies and Coronary Artery Disease in People with HIV: A Cohort Study.Viruses · 2025Article
- A potential prognostic marker for hematologic neoplasms: CD58.Frontiers in oncology · 2025Review
- Association of T-Cell Phenotypes With Peri-Coronary Inflammation in People With and Without HIV and Without Cardiovascular Disease.Circulation. Cardiovascular imaging · 2025Observational
- Inflammatory and Immune Mechanisms for Atherosclerotic Cardiovascular Disease in HIV.International journal of molecular sciences · 2024Review
- Inflammation in HIV and Its Impact on Atherosclerotic Cardiovascular Disease.Circulation research · 2024Review
- Cytomegalovirus Infection Facilitates the Costimulation of CD57+CD28- CD8 T Cells in HIV Infection and Atherosclerosis via the CD2-LFA-3 Axis.Journal of immunology (Baltimore, Md. : 1950) · 2024Article
- Cytokine Profiling of Plasma and Atherosclerotic Plaques in Patients Undergoing Carotid Endarterectomy.International journal of molecular sciences · 2024Article
- Characterizing Epstein-Barr virus infection of the central nervous system in Zambian adults living with HIV.Journal of neurovirology · 2023Article
- Indirect effects of cytomegalovirus infection: Implications for vaccine development.Reviews in medical virology · 2023Review
- Effect of Cytomegalovirus on the Immune System: Implications for Aging and Mental Health.Current topics in behavioral neurosciences · 2023Article
- CD4Frontiers in immunology · 2023Article
- Article
- Inflammation, Immune Senescence, and Dysregulated Immune Regulation in the Elderly.Frontiers in aging · 2022Review
- Diminished Peripheral CD29hi Cytotoxic CD4+ T Cells Are Associated With Deleterious Effects During SIV Infection.Frontiers in immunology · 2021Article
Corrections and comments
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Authors and funding
20 authors at 6 institutions in 2 countries.
Bonnie ChenCenter for AIDS Research, Division of Infectious Diseases and HIV Medicine, Department of Medicine, Case Western Reserve University/University Hospitals Cleveland Medical Center, Cleveland, OH 44106.
Stephen R MorrisLouis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, OH 44106.ORCID 0000-0003-3232-8329
Soumya PanigrahiCenter for AIDS Research, Division of Infectious Diseases and HIV Medicine, Department of Medicine, Case Western Reserve University/University Hospitals Cleveland Medical Center, Cleveland, OH 44106.
Gillian M MichaelsonCenter for AIDS Research, Division of Infectious Diseases and HIV Medicine, Department of Medicine, Case Western Reserve University/University Hospitals Cleveland Medical Center, Cleveland, OH 44106.
Jonathan M WyrickCenter for AIDS Research, Division of Infectious Diseases and HIV Medicine, Department of Medicine, Case Western Reserve University/University Hospitals Cleveland Medical Center, Cleveland, OH 44106.
Alexey A KomissarovLaboratory of Atherothrombosis, Moscow State University of Medicine and Dentistry, Moscow 127473, Russia.
Daria PotashnikovaLaboratory of Atherothrombosis, Moscow State University of Medicine and Dentistry, Moscow 127473, Russia.ORCID 0000-0002-0098-827X
Anna LebedevaLaboratory of Atherothrombosis, Moscow State University of Medicine and Dentistry, Moscow 127473, Russia.
Souheil-Antoine YounesCenter for AIDS Research, Division of Infectious Diseases and HIV Medicine, Department of Medicine, Case Western Reserve University/University Hospitals Cleveland Medical Center, Cleveland, OH 44106.
Karem HarthHarrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center/Case Western Reserve University, Cleveland, OH 44106.
Vikram S KashyapHarrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center/Case Western Reserve University, Cleveland, OH 44106.
Elena VasilievaLaboratory of Atherothrombosis, Moscow State University of Medicine and Dentistry, Moscow 127473, Russia.
Leonid MargolisEunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892.
David A ZidarLouis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, OH 44106.
Scott F SiegCenter for AIDS Research, Division of Infectious Diseases and HIV Medicine, Department of Medicine, Case Western Reserve University/University Hospitals Cleveland Medical Center, Cleveland, OH 44106.ORCID 0000-0002-1769-8682
Carey L ShiveLouis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, OH 44106.
Nicholas T FunderburgDivision of Medical Laboratory Science, School of Health and Rehabilitation Sciences, Ohio State University, Columbus, OH 43210; and.
Sara GianellaCenter for AIDS Research, Division of Infectious Diseases, Department of Medicine, University of California, San Diego, La Jolla, CA 92093.ORCID 0000-0002-9927-0849
Michael M LedermanCenter for AIDS Research, Division of Infectious Diseases and HIV Medicine, Department of Medicine, Case Western Reserve University/University Hospitals Cleveland Medical Center, Cleveland, OH 44106.
Michael L FreemanCenter for AIDS Research, Division of Infectious Diseases and HIV Medicine, Department of Medicine, Case Western Reserve University/University Hospitals Cleveland Medical Center, Cleveland, OH 44106; MLF62@case.edu.ORCID 0000-0002-7690-5258
University Hospitals of Cleveland · USMoscow State University of Medicine and Dentistry · RULouis Stokes Cleveland VA Medical Center · USNational Institutes of Health · USThe Ohio State University · USUniversity of California San Diego · US
Funding
UC San Diego Clinical and Translational Research InstituteUL1TR001442 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FIRESTEIN, GARY S, HOGARTH, MICHAEL · 2015 to 2024
$88.3MVirologyP30AI036214 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI David Mitchell Smith · 1994 to 2026
$78.4MWG3: HIV, Co-infections and Co-morbiditiesP30AI036219 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI Alan David Levine · 1994 to 2026
$50.0MCase Clinical Trials Unit: Administrative Supplement NOSI AI-20-031.UM1AI069501 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI George Yendewa · 2012 to 2026
$40.4MPrimary Infection Resource Consortium (PIRC)R24AI106039 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LITTLE, SUSAN JANET · 2013 to 2021
$23.1MCase AIDS Clinical Trials UnitU01AI069501 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI LEDERMAN, MICHAEL MARCEL · 2007 to 2011
$14.7MViral transmission and pathogenesis in human tissuesZIAHD008968 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI MARGOLIS, LEONID B. · 2018 to 2023
$12.2MSpecimen Acquisition and Distribution CoreP01AI076174 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI LANDAY, ALAN L · 2008 to 2012
$10.9MRevealing Reservoirs during Rebound (R3)P01AI131385 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DEGRUTTOLA, VICTOR GERARD · 2017 to 2021
$8.7MCellular mediators of vascular inflammation in treated HIV-infectionR01HL134544 · NHLBI · OHIO STATE UNIVERSITY · PI FUNDERBURG, NICHOLAS T. · 2016 to 2019
$3.2MEffect of Declining Sex Hormones on HIV persistence in HIV Infected Women on ARTR21HD094646 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GIANELLA WEIBEL, SARA · 2017 to 2018
$441kRole of IL-6 and IL-1b in immune dysfunction during aging, HIV, and HCV infectionIK2CX001471 · VA · LOUIS STOKES CLEVELAND VA MEDICAL CENTER · PI SHIVE, CAREY LYNN · 2017 to 2021
–CSRD VA IK2 CX001471NCATS NIH HHS UL1 TR001442NHLBI NIH HHS R01 HL134544NIAID NIH HHS P01 AI076174NIAID NIH HHS P01 AI131385NIAID NIH HHS P30 AI036214NIAID NIH HHS P30 AI036219NIAID NIH HHS R24 AI106039NIAID NIH HHS U01 AI069501NIAID NIH HHS UM1 AI069501NICHD NIH HHS R21 HD094646
Abstract
Cytotoxic CD4 T cells are linked to cardiovascular morbidities and accumulate in both HIV and CMV infections, both of which are associated with increased risk of cardiovascular disease (CVD). In this study, we identify CMV coinfection as a major driver of the cytotoxic phenotype, characterized by elevated CD57 expression and reduced CD28 expression, in circulating CD4 T cells from people living with HIV infection, and investigate potential mechanisms linking this cell population to CVD. We find that human CD57
Indexed as
Blood VesselsCD28 AntigensCD4-Positive T-LymphocytesCD57 AntigensCD58 AntigensCell MovementChemokine CX3CL1CoinfectionCX3C Chemokine Receptor 1CytomegalovirusCytomegalovirus InfectionsCytotoxicity, ImmunologicHIV-1HIV InfectionsHumansPlaque, AtheroscleroticCD28 AntigensCD57 AntigensCD58 AntigensChemokine CX3CL1CX3C Chemokine Receptor 1CX3CR1 protein, humanCXCR3 protein, humanReceptors, CXCR3
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.