Evidence map›Paper›PMID 32229366›Full record

ReviewCurrent opinion in cell biology2020

Biophysical forces in membrane bending and traffic.

Kasey J Day, Jeanne C Stachowiak

Abstract readReview
In one paragraph

Review in Current opinion in cell biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Linking Planar Cell Polarity to Mechanotransduction During Morphogenesis.BioEssays : news and reviews in molecular, cellular and developmental biology · 2026
    Review
  3. Article
  4. Chlamydia trachomatis invasion: a duet of effectors.Biochemical Society transactions · 2025
    Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Kasey J DayDepartment of Biomedical Engineering, 107 W. Dean Keeton St., C0800, Austin, TX, 78712, USA.
Jeanne C StachowiakDepartment of Biomedical Engineering, 107 W. Dean Keeton St., C0800, Austin, TX, 78712, USA; Institute for Cellular and Molecular Biology, The University of Texas at Austin, Norman Hackerman Building, 100 East 24th St., NHB 4500, Austin, TX, 78712, USA. Electronic address: jcstach@austin.utexas.edu.

Funding

Intrinsically disordered proteins as physical drivers of membrane trafficR01GM120549 · NIGMS · UNIVERSITY OF TEXAS AT AUSTIN · PI STACHOWIAK, JEANNE CASSTEVENS · 2017 to 2020
$1.4M
Protein Droplets as Catalysts of Coated Vesicle AssemblyF32GM133138 · NIGMS · UNIVERSITY OF TEXAS AT AUSTIN · PI DAY, KASEY JILL · 2019 to 2021
$144k
NIGMS NIH HHS F32 GM133138NIGMS NIH HHS R01 GM120549
6 · The paper itself

Abstract

Intracellular trafficking requires extensive changes in membrane morphology. Cells use several distinct molecular factors and physical cues to remodel membranes. Here, we highlight recent advances in identifying the biophysical mechanisms of membrane curvature generation. In particular, we focus on the cooperation of molecular and physical drivers of membrane bending during three stages of vesiculation: budding, cargo selection, and scission. Taken together, the studies reviewed here emphasize that, rather than a single dominant mechanism, several mechanisms typically work in parallel during each step of membrane remodeling. Important challenges for the future of this field are to understand how multiple mechanisms work together synergistically and how a series of stochastic events can be combined to achieve a deterministic result-assembly of the trafficking vesicle.

Indexed as

Biophysical PhenomenaActinsCell MembraneEndosomal Sorting Complexes Required for TransportMacromolecular SubstancesProtein TransportActinsEndosomal Sorting Complexes Required for TransportMacromolecular Substances

Identifiers

PMID32229366
PMCPMC7529674

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.