ReviewBiological psychiatry2020
Can I Get a Witness? Using Vicarious Defeat Stress to Study Mood-Related Illnesses in Traditionally Understudied Populations.
Review in Biological psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
37 citing papers in PubMed, 75 citations in OpenAlex.
- Behavioral effects of a chronic envy-like stress paradigm in mice using an adjacent cage model.IBRO neuroscience reports · 2026Article
- Data-Driven Analysis Identifies Novel Modulation of Social Behavior in Female Mice Witnessing Chronic Social Defeat Stress.Biological psychiatry · 2025Article
- Not just a witness: Highlighting the utility of witness social defeat stress for the examination of neuroimmune-cardiovascular interactions across diverse populations.Neurobiology of stress · 2025Review
- Oleoylethanolamide restores stress-induced prepulse inhibition deficits and modulates inflammatory signaling in a sex-dependent manner.Psychopharmacology · 2025Article
- Delta opioid receptor agonists activate PI3K-mTORC1 signaling in parvalbumin-positive interneurons in mouse infralimbic prefrontal cortex to exert acute antidepressant-lie effects.Molecular psychiatry · 2025Article
- Acute and vicarious effects of social defeat stress on social behaviour in California mice,Animal behaviour · 2025Article
- Repeated social stress increases posterior medial amygdala neuronal activity in stress-susceptible adult male rats.Journal of neurophysiology · 2025Article
- A Novel Mouse Model of Depression: Advantages in Immune Research and Clinical Translation.International journal of biological sciences · 2025Article
- Behavioral coping with chronic defeat stress in mice: A systematic review of current protocols.Neurobiology of stress · 2024Review
- Contagion of depression: a double-edged sword.Translational psychiatry · 2024Article
- Prior Negative Experience Biases Activity of Medial Amygdala during Interstrain Social Engagement in Male Rats.eNeuro · 2024Article
- Individual Differences in Volitional Social Self-Administration and Motivation in Male and Female Mice Following Social Stress.Biological psychiatry · 2024Article
- Article
- Social defeat stress induces an anxiety-like outcome in male prairie voles (Oxford open neuroscience · 2024Article
- Translational models of stress and resilience: An applied neuroscience methodology review.Neuroscience applied · 2024Review
- Sex-Specific Alterations in Spatial Memory and Hippocampal AKT-mTOR Signaling in Adult Mice Pre-exposed to Ketamine and/or Psychological Stress During Adolescence.Biological psychiatry global open science · 2024Article
- Central regulation of stress-evoked peripheral immune responses.Nature reviews. Neuroscience · 2023Review
- Site-Specific knockdown of microglia in the locus coeruleus regulates hypervigilant responses to social stress in female rats.Brain, behavior, and immunity · 2023Article
- Effect of early-life stress or fluoxetine exposure on later-life conditioned taste aversion learning in Sprague-Dawley rats.Neuroscience letters · 2022Article
- Quantifying Sex Differences in Behavior in the Era of "Big" Data.Cold Spring Harbor perspectives in biology · 2022Review
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
The chronic social defeat stress model has been instrumental in shaping our understanding of neurobiology relevant to affect-related illnesses, including major depressive disorder. However, the classic chronic social defeat stress procedure is limited by its exclusive application to adult male rodents. We have recently developed a novel vicarious social defeat stress procedure wherein one mouse witnesses the physical defeat bout of a conspecific from the safety of an adjacent compartment. This witness mouse develops a similar behavioral phenotype to that of the mouse that physically experiences social defeat stress, modeling multiple aspects of major depressive disorder. Importantly, this new procedure allows researchers to perform vicarious social defeat stress in males or females and in juvenile mice, which typically are excluded from classic social defeat experiments. Here we discuss several recent advances made using this procedure and how its application provides a new preclinical approach to study the neurobiology of psychological stress-induced phenotypes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.