Evidence map›Paper›PMID 32228664›Full record

Observational studyBMC surgery2020

Single-stage repair of contaminated hernias using a novel antibiotic-impregnated biologic porcine submucosa tissue matrix.

Samuel Minor, Carl J Brown, Paul S Rooney, Jason P Hodde, Lisa Julien, Tracy M Scott, Ahmer A Karimuddin, Manoj J Raval, P Terry Phang

Registry-linked trialOpen access · goldAbstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in BMC surgery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02401334 (Feasibility Study of the Antimicrobial Hernia Repair Device for Repair of Ventral or Incisional Hernia), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02401334 nacompletednot on this map

Feasibility Study of the Antimicrobial Hernia Repair Device for Repair of Ventral or Incisional Hernia

TypeinterventionalSponsorCook Group IncorporatedRan2015 to 2018Enrolled24ConditionsVentral Hernia, Incisional HerniaArmsCook® Antimicrobial Hernia Repair Device
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 3 countries.

Samuel MinorQE2 Hospital, QEII Health Sciences Centre Dalhousie University, 1278 Tower Road, Halifax, NS, B3H 2Y9, Canada. sam.minor@nshealth.ca.
Carl J BrownSt. Paul's Hospital, 1081 Burrard Street, Vancouver, BC, V6Z 1Y6, Canada.
Paul S RooneyRoyal Liverpool Hospital, Prescot Street, Merseyside, Liverpool, L7 8XP, UK.
Jason P HoddeCook Biotech Incorporated, 1425 Innovation Place, West Lafayette, IN, 47906, USA.
Lisa JulienQE2 Hospital, QEII Health Sciences Centre Dalhousie University, 1278 Tower Road, Halifax, NS, B3H 2Y9, Canada.
Tracy M ScottSt. Paul's Hospital, 1081 Burrard Street, Vancouver, BC, V6Z 1Y6, Canada.
Ahmer A KarimuddinSt. Paul's Hospital, 1081 Burrard Street, Vancouver, BC, V6Z 1Y6, Canada.
Manoj J RavalSt. Paul's Hospital, 1081 Burrard Street, Vancouver, BC, V6Z 1Y6, Canada.
P Terry PhangSt. Paul's Hospital, 1081 Burrard Street, Vancouver, BC, V6Z 1Y6, Canada.
St. Paul's Hospital · CACook Biotech (United States) · USDalhousie University · CAQueen Elizabeth II Health Sciences Centre · CAUniversity of Liverpool · GB

Funding

Cook Medical (US) NA
6 · The paper itself

Abstract

backgroundSingle-stage repair of incisional hernias in contaminated fields has a high rate of surgical site infection (30-42%) when biologic grafts are used for repair. In an attempt to decrease this risk, a novel graft incorporating gentamicin into a biologic extracellular matrix derived from porcine small intestine submucosa was developed.

methodsThis prospective, multicenter, single-arm observational study was designed to determine the incidence of surgical site infection following implantation of the device into surgical fields characterized as CDC Class II, III, or IV.

resultsTwenty-four patients were enrolled, with 42% contaminated and 25% dirty surgical fields. After 12 months, 5 patients experienced 6 surgical site infections (21%) with infection involving the graft in 2 patients (8%). No grafts were explanted.

conclusionsThe incorporation of gentamicin into a porcine-derived biologic graft can be achieved with no noted gentamicin toxicity and a low rate of device infection for patients undergoing single-stage repair of ventral hernia in contaminated settings.

trial registrationThe study was registered March 27, 2015 at www.clinicaltrials.gov as NCT02401334.

Indexed as

AgedAnimalsAnti-Bacterial AgentsFemaleHernia, VentralHerniorrhaphyHumansIncidenceIncisional HerniaMaleMiddle AgedPilot ProjectsProspective StudiesSurgical Wound InfectionSwineTreatment OutcomeAnti-Bacterial AgentsAbdominal wall reconstructionContaminationGraftHernia repair

Identifiers

PMID32228664
PMCPMC7106678
OpenAlexW3013868190

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.