Evidence map›Paper›PMID 32228461›Full record

ArticleBMC plant biology2020

Annotation of genes involved in high level of dihydromyricetin production in vine tea (Ampelopsis grossedentata) by transcriptome analysis.

Xiaohua Li, Minhui Cao, Weibo Ma, Caihua Jia, Jinghuan Li, Mingxing Zhang, Changchun Liu, Zhenzhen Cao, Mohammad Omar Faruque, Xuebo Hu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC plant biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Review of the Composition and Antimicrobial Roles of Extracts of Vine Tea (Ampelopsis grossedentata).Medical science monitor : international medical journal of experimental and clinical research · 2026
    Review
  3. Pan-genome assembly of vine tea (Horticulture research · 2026
    Article
  4. Article
  5. The near-complete genome assembly ofFrontiers in plant science · 2025
    Article
  6. Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Xiaohua LiLaboratory of Natural Medicine and Molecular Engineering, Department of Medicinal Plant, College of Plant Science and Technology, Huazhong Agriculture University, Wuhan, Hubei, China.
Minhui CaoDepartment of Chemistry, College of Science, Huazhong Agriculture University, Wuhan, Hubei, China.
Weibo MaLaboratory of Natural Medicine and Molecular Engineering, Department of Medicinal Plant, College of Plant Science and Technology, Huazhong Agriculture University, Wuhan, Hubei, China.
Caihua JiaKey Laboratory of Environment Correlative Dietology (Ministry of Education), College of Food Science and Technology, Huazhong Agricultural University, Wuhan, Hubei, China.
Jinghuan LiLaboratory of Natural Medicine and Molecular Engineering, Department of Medicinal Plant, College of Plant Science and Technology, Huazhong Agriculture University, Wuhan, Hubei, China.
Mingxing ZhangLaboratory of Natural Medicine and Molecular Engineering, Department of Medicinal Plant, College of Plant Science and Technology, Huazhong Agriculture University, Wuhan, Hubei, China.
Changchun LiuLaboratory of Natural Medicine and Molecular Engineering, Department of Medicinal Plant, College of Plant Science and Technology, Huazhong Agriculture University, Wuhan, Hubei, China.
Zhenzhen CaoKey Laboratory of Environment Correlative Dietology (Ministry of Education), College of Food Science and Technology, Huazhong Agricultural University, Wuhan, Hubei, China.
Mohammad Omar FaruqueLaboratory of Natural Medicine and Molecular Engineering, Department of Medicinal Plant, College of Plant Science and Technology, Huazhong Agriculture University, Wuhan, Hubei, China.
Xuebo HuLaboratory of Natural Medicine and Molecular Engineering, Department of Medicinal Plant, College of Plant Science and Technology, Huazhong Agriculture University, Wuhan, Hubei, China. xuebohu@mail.hzau.edu.cn.ORCID http://orcid.org/0000-0003-2482-9000
Huazhong Agricultural University · CN

Funding

Fundamental Research Funds for the Central Universities 2662015QD005Fundamental Research Funds for the Central Universities 2662017PY104Key Technology Research and Development Program of Shandong (CN) 2017YFD0501500National Natural Science Foundation of China 31600234
6 · The paper itself

Abstract

backgroundLeaves of the medicinal plant Ampelopsis grossedentata, which is commonly known as vine tea, are used widely in the traditional Chinese beverage in southwest China. The leaves contain a large amount of dihydromyricetin, a compound with various biological activities. However, the transcript profiles involved in its biosynthetic pathway in this plant are unknown.

resultsWe conducted a transcriptome analysis of both young and old leaves of the vine tea plant using Illumina sequencing. Of the transcriptome datasets, a total of 52.47 million and 47.25 million clean reads were obtained from young and old leaves, respectively. Among 471,658 transcripts and 177,422 genes generated, 7768 differentially expressed genes were identified in leaves at these two stages of development. The phenylpropanoid biosynthetic pathway of vine tea was investigated according to the transcriptome profiling analysis. Most of the genes encoding phenylpropanoid biosynthesis enzymes were identified and found to be differentially expressed in different tissues and leaf stages of vine tea and also greatly contributed to the biosynthesis of dihydromyricetin in vine tea.

conclusionsTo the best of our knowledge, this is the first formal study to explore the transcriptome of A. grossedentata. The study provides an insight into the expression patterns and differential distribution of genes related to dihydromyricetin biosynthesis in vine tea. The information may pave the way to metabolically engineering plants with higher flavonoid content.

Indexed as

AmpelopsisChinaFlavonoidsFlavonolsGene ExpressionGene Expression ProfilingdihydromyricetinFlavonoidsFlavonolsDihydromyricetinGene expressionPhenylpropanoid pathwayTranscriptome analysisVine tea

Identifiers

PMID32228461
PMCPMC7106717
OpenAlexW3013414427

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.