ArticleThe journal of headache and pain2020
Phase dependent hypothalamic activation following trigeminal input in cluster headache.
Article in The journal of headache and pain, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Exploring the potential of deep brain stimulation in managing cluster headache: a systematic review.BMC neurology · 2025Pooled it
- Premonitory phase in primary headaches: shared and divergent mechanisms in migraine and cluster headache, the Junior Editorial Board Members' vision.The journal of headache and pain · 2026Review
- Visualizing nociplastic pain: functional hyperexcitability in neuropathic and idiopathic facial pain syndromes.The journal of headache and pain · 2025Article
- Hallmarks of primary headache: part 3 - cluster headache.The journal of headache and pain · 2025Review
- Cluster Headache and Migraine Shared and Unique Insights: Neurophysiological Implications, Neuroimaging, and Biomarkers: A Comprehensive Review.Journal of clinical medicine · 2025Review
- Unraveling the relationship between inflammation and cluster headache.Frontiers in neurology · 2025Review
- Potential hypothalamic mechanisms in trigeminal neuropathic pain: a comparative analysis with migraine and cluster headache.The journal of headache and pain · 2024Review
- Cluster headache and kynurenines.The journal of headache and pain · 2023Article
- Review
- Functional magnetic resonance imaging of headache: Issues, best-practices, and new directions, a narrative review.Headache · 2023Review
- Debate: Are cluster headache and migraine distinct headache disorders?The journal of headache and pain · 2022Review
- CGRP-Targeted Therapy for Episodic and Chronic Cluster Headache.Current pain and headache reports · 2022Review
- The molecular clock gene cryptochrome 1 (Cephalalgia : an international journal of headache · 2021Article
- Exploring the Connection Between Sleep and Cluster Headache: A Narrative Review.Pain and therapy · 2020Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundTask-free imaging approaches using PET have shown the posterior hypothalamus to be specifically activated during but not outside cluster headache attacks. Evidence from task related functional imaging approaches however is scarce.
methodsTwenty-one inactive cluster headache patients (episodic cluster headache out of bout), 16 active cluster headache patients (10 episodic cluster headache in bout, 6 chronic cluster headache) and 18 control participants underwent high resolution brainstem functional magnetic resonance imaging of trigeminal nociception using gaseous ammonia as a painful stimulus.
resultsFollowing trigeminonociceptive stimulation with ammonia there was a significantly stronger activation within the posterior hypothalamus in episodic cluster headache patients out of bout when compared to controls. When contrasting estimates of the pain contrast, active cluster headache patients where in between the two other groups but did not differ significantly from either.
conclusionThe posterior hypothalamus might thus be hyperexcitable in cluster headache patients outside the bout while excitability to external nociceptive stimuli decreases during in bout periods, probably due to frequent hypothalamic activation and possible neurotransmitter exhaustion during cluster attacks.
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