ArticleJCO global oncology2020
Biomass Smoke Exposure Is Associated With Gastric Cancer and Probably Mediated Via Oxidative Stress and DNA Damage: A Case-Control Study.
Article in JCO global oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 27 citations in OpenAlex.
- Use of free blood in the stomach to diagnose gastric mucosal lesions prior to endoscopy: the Sanguis-filum.BMC research notes · 2026Article
- In-depth Biological Monitoring to Estimate Effects of Red or Processed Meat on Colorectal Cancer.Journal of Cancer · 2026Article
- Age-stratified risk analysis of gastric cancer: a retrospective hospital-based study of helicobacter pylori, smoking, and dietary patterns in South China across three age groups.Frontiers in oncology · 2026Article
- Exposure to household air pollution in relation to stomach and esophageal cancer in Xuanwei, China.Environment international · 2025Article
- Fasting Gastric Juice Melatonin Levels in Relation to Gastroduodenal Pathologies Among Zambian Patients: A Cross Sectional Study.Health science reports · 2025Article
- Mapping the cancer research landscape across Zambia: evidence to support national cancer control planning.Ecancermedicalscience · 2025Review
- Analysis of the loss of Epithelial Cadherin expression in gastric cancer in Zambia.Medical journal of Zambia · 2025Article
- Controlled human exposures: a review and comparison of the health effects of diesel exhaust and wood smoke.Particle and fibre toxicology · 2024Review
- Endoscopic diagnosis of gastric and oesophageal cancer in Lusaka, Zambia: a retrospective analysis.BMC gastroenterology · 2024Article
- Prevalence of Clarithromycin-Resistant Helicobacter pylori Strains in Zambia: A Sub-Saharan African Country.Digestive diseases (Basel, Switzerland) · 2024Article
- Wood cookstove use is associated with gastric cancer in Central America and mediated by host genetics.Scientific reports · 2023Article
- Knowledge and Awareness About Gastric Cancer Among the General Population in Al-Baha City, Saudi Arabia.Cureus · 2023Article
- Analysis of the proportion of university teaching hospital gastric cancer data included in the Zambia national cancer registry.African health sciences · 2023Article
- Article
- Evaluation of the association between gastric cancer and plasma selenium in Zambian adults: a case-control study.Ecancermedicalscience · 2022Article
- Association between oesophageal cancer and biomass smoke exposure: a case-control study.Ecancermedicalscience · 2022Article
- Helicobacter pylori infection and hypochlorhydria in Zambian adults and children: A secondary data analysis.PloS one · 2021Article
- Estimated 24-hour urinary sodium excretion as a risk factor for oxidative stress in Zambian adults: A cross-sectional study.PloS one · 2020Article
- Programmed Death Ligand-1 Expression in Gastric Cancer Cases in Zambia.Journal of agricultural and biomedical sciencesArticle
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
Abstract
purposeWe investigated the association between gastric cancer and environmental and dietary exposures. In addition, we explored probable mechanistic pathways for the influence of biomass smoke on gastric carcinogenesis. PATIENTS AND
methodsThe study was conducted in Lusaka, Zambia. Questionnaires were used to collect data on risk factors, whereas enzyme-linked immunosorbent assays and high-performance liquid chromatography were used to measure biologic exposures. Study data were analyzed using contingency tables and logistic regression.
resultsWe enrolled 72 patients with gastric adenocarcinoma and 244 controls. Gastric cancer was positively associated with rural residence (odds ratio [OR], 2.9; 95% CI, 1.5 to 5.3), poverty (OR, 4.2; 95% CI, 1.9 to 9.1), and daily consumption of processed meat (OR, 6.4; 95% CI, 1.3 to 32) and negatively associated with consumption of green vegetables (OR, 0.2; 95% CI, 0.1 to 0.5). Gastric cancer was also associated with biomass smoke exposure (OR, 3.5; 95% CI, 1.9 to 6.2;
conclusionIn Zambia, exposure to biomass smoke, daily consumption of processed meat, and poverty are risk factors for gastric cancer, whereas daily consumption of green vegetables is protective against gastric cancer. Exposure to biomass smoke was associated with evidence of oxidative stress and DNA damage, suggesting mechanistic plausibility for the observed association, and the association was restricted to intestinal-type gastric cancer.
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